Human Genetics
Promotive effect of comprehensive management on achieving blood glucose control in senile type 2 diabetics
Authors: S.-T. Yan, C.-X. Li, C.-L. Li, J. Li, Y.-H. Shao, Y. Liu, W.-W. Zhong, F.-S. Fang, B.-R. Sun and H. Tian
The aim of this study was to evaluate the control of blood glucose and glycosylated hemoglobin A1c (HbA1c) and its influencing factors, in elderly type 2 diabetic mellitus (T2DM) patients undergoing comprehensive management. After years of comprehensive prevention of and control measures for diabetes, elderly T2DM patients who were receiving long-term hea.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.16
Comparative analysis of human masculinity
Authors: B.K. Bhowmick, N. Takahata, M. Watanabe and Y. Satta
To study rapidly evolving male specific Y (MSY) genes we retrieved and analyzed nine such genes. VCY, HSFY and RBMY were found to have functional X gametologs, but the rest did not. Using chimpanzee orthologs for XKRY, CDY, HSFY, PRY, and TSPY, the average silent substitution is estimated as 0.017 ± 0.006/site and the s.. Read More»
- Genet. Mol. Res. 5(4):
Correlation of coronary artery stenosis evaluation with left heart structure and function by multi-slice computed tomography
Authors: L.N. Song, A.D. Cao, Y.J. Niu and N. Liu
The aim of this study was to determine the impact of multi-slice computed tomography (MSCT) evaluation of coronary artery stenosis on left heart structure and systolic function. Coronary artery CT angiography was performed in 200 patients diagnosed with coronary heart disease, and then according to the AHA coronary artery 17-s.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.9
- DOI:
- 10.4238/2014.August.7.9
Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells
Authors: J.Z. Mei, G.J. Liu, X.J. Zhang, J.Z. Zhao and R.T. Feng
We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and E.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.18
Expression and clinical significance of obesity-associated gene STEAP4 in obese children
Authors: H.M. Xu, Y.Z. Cui, W.G. Wang, H.X. Cheng, Y.J. Sun, H.Y. Zhao and Y.Q. Yan
The aim of this study was to investigate the expression and clinical significance of the obesity-associated gene STEAP4 in obese children. Fifty-three obese children and 33 children with a standard body weight (control) from our hospital were recruited to this study. The expression of STEAP4 mRNA and protein in the adipose tis.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048705
- DOI:
- 10.4238/gmr.15048705
The influence of parental origin of X chromosome genes on the stature of patients with 45 X Turner syndrome
Authors: Kochi C, Longui CA, Lemos-Marini SHV, Guerra-Junior G, Melo MB, Calliari LEP and Monte O
Thirty-seven 45 X Turner syndrome patients with confirmed peripheral blood lymphocyte karyotype were initially selected to determine the origin of the retained X chromosome and to correlate it with their parents’ stature. Blood samples were available in 25 families. The parental origin of the X chromosome was determined .. Read More»
- Genet. Mol. Res. 6(1):
Congenital bilateral anorchia: hormonal, molecular and imaging study of a case
Authors: I. Rousso, D. Iliopoulos, F. Athanasiadou, L. Zavopoulou, G. Vassiliou and N. Voyiatzis
The aetiology of congenital bilateral anorchia is unknown. For many years there was speculation of an association between genetic factors and anorchia. We performed different tests in an anorchid boy, 2.5 years old, presented to us with micropenis and absence of both testes, in order to determine any possible factors contribut.. Read More»
- Genet. Mol. Res. 5(4):
Translocation breakpoints of chromosome 1 in male carriers: clinical features and implications for genetic counseling
Authors: R.X. Wang, H.G. Zhang, Y. Pan, S. Chen, F.G. Yue, D.L. Zhu and R.Z. Liu
Reciprocal translocation is closely associated with male infertility and recurrent miscarriages. Balanced reciprocal translocations associated with reproductive failures are predominantly observed on chromosome 1. Additionally, infertile male patients present a number of breakpoints throughout chromosome 1. A translocation bre.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048707
- DOI:
- 10.4238/gmr.15048707
Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma
Authors: L.L. Chen, Y. Shen, J.B. Zhang, S. Wang, T. Jiang, M.Q. Zheng, Z.J. Zheng and C.X. Chen
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism i.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048723
- DOI:
- 10.4238/gmr.15048723
Molecular thrombophilic profile in Mexican patients with idiopathic recurrent pregnancy loss
Authors: J.J. L?³pez-Jim?©nez, ?. Porras-Dorantes, C.I. Ju?¡rez-V?¡zquez,J.E. Garc?a-Ortiz, C.A. Fuentes-Ch?¡vez, I.J. Lara-Navarro and A.R. Jaloma-Cruz
Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This stu.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048728
- DOI:
- 10.4238/gmr.15048728