Human Genetics
Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment
Authors: M. Luo, X.H. Zhou, T. Zou, K. Keyim and L.M. Dong
We investigated type II deiodinase (DIO2 ) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.10
- DOI:
- 10.4238/2015.May.22.10
Correlation between magnetic resonance perfusion weighted imaging of radiation brain injury and pathology
Authors: X.J. Liu, C.F. Duan, W.W. Fu, L. Niu, Y. Li, Q.L. Sui and W.J. Xu
We used magnetic resonance perfusion weighted imaging and pathological evaluation to examine different stages of radiation-induced brain injury and to investigate the correlation between the relative cerebral blood volume (rCBV) ratio and vascular endothelial growth factor (VEGF). Thirty adult rats were randomly divided into 2 groups: control and radiatio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Relationship between polymorphism of SOCS-3 and dyslipidemia in China Xinjiang Uygur
Authors: X.G. Yao, J. Meng, L. Zhou, N. Lin, J. Hong, M. Heizhati and N.F. Li
We investigated the relationship between the polymorphism of SOCS-3 and dyslipidemia of people from Uygur in Xinjiang, China. This cross-sectional study included 1379 participants in a Hetian Xinjiang Uygur population who were 30-70 years of age and were not from interracial marriages of 3 generations; all subjects were genotyped (909 dyslipidemia subject.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.13
- DOI:
- 10.4238/2015.February.13.13
Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis
Authors: H. Liu, H.F. Ma and Y.K. Chen
The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform lit.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.17
- DOI:
- 10.4238/2015.February.13.17
Expression and clinical significance of LRRC4 in benign and malignant nasopharyngeal diseases
Authors: X.-J. Zhou, Y. Wang, L.-J. Zhang and J.-H. Chen
The aim of this study was to investigate the expression of LRRC4 in nasopharyngeal carcinomas, nasopharyngeal precancerous lesions, and nasopharyngitis as well as the clinical significance of LRRC4. Fifty patients with nasopharyngeal carcinoma were selected as study subjects; 28 patients with chronic nasopharyngitis and 22 patients with nasopharyngeal pre.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Relationship between clinicopathological features and HIF-2�± in gastric adenocarcinoma
Authors: N. Li, H.X. Wang, C. Qin, X.H. Wang and F.Y. Han
Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative rever.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.19
- DOI:
- 10.4238/2015.February.13.19
Investigation on the association between NLRP3 gene polymorphisms and susceptibility to primary gout
Authors: L.F. Wang, Y.J. Ding, Q. Zhao, X.L. Zhang
We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
Clinical significance of fibroblast growth factor receptor-3 mutations in bladder cancer: a systematic review and meta-analysis..
Authors: X. Liu, W. Zhang, D. Geng, J. He, Y. Zhao and L. Yu
Mutations in the fibroblast growth factor receptor-3 (FGFR3) gene are frequently found in bladder cancer, but their prognostic value remains controversial. To globally summarize the association between FGFR3 mutations and the grade and stage of bladder cancer, and to analyze the predictive role of FGFR3 mutations with respect .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.12
- DOI:
- 10.4238/2014.February.20.12
Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk
Authors: X.F. Zhang, T. Liu, Y. Li and S. Li
ABSTRACT. We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restrictio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors
Authors: P. Sun, N. Su, F.Z. Lin, L. Ma, H.J. Wang, X. Rong, Y.D. Dai4, J. Li, Z.W. Jian6, L.H. Tang, W. Xiao and C.Q. Li
Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-li.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015