Human Genetics
Construction of an adenoviral expression vector carrying FLAG and hrGFP-1 genes and its expression in bone marrow mesenchymal stem cells
Authors: G.X. Wang, L. Hu2, Z. Zhang and D.P. Liu
The aim of this study was to construct an adenoviral expression vector for vascular endothelium growth factor 121 (VEGF121)-FLAG and humanized Renilla reniformis green fluorescent protein (hrGFP-1) genes, and to observe their expressions in bone marrow mesenchymal stem cells. Using pTG19T-VEGF121 as a template, polymerase chai.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.8
- DOI:
- 10.4238/2014.February.20.8
Construction and expression of a heterologous protein in Lactococcus lactis by using the nisin-controlled gene expression system: the case of the PRRSV ORF6 gene
Authors: Z.H. Wang, Y.L. Wang and X.Y. Zeng
The porcine reproductive and respiratory syndrome virus (PRRSV) continues to be a threat, exerting significant economic effects on the swine industry worldwide. However, none of the current commercially available vaccines can completely prevent respiratory infection, trans-placental transmission, pig-to-pig transmission of the.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.10
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.10
Development of two multiplex mini-sequencing panels of ancestry informative SNPs for studies in Latin Americans: an application to populations of the State of Minas Gerais (Brazil)
Authors: M.C.F. Silva*, L.W. Zuccherato*, G.B. Soares-Souza, Z.M. Vieira, L. Cabrera, P. Herrera, J. Balqui, C. Romero, H. Jahuira, R.H. Gilman, M.L. Martins and E. Tarazona-Santos
Admixture occurs when individuals from parental populations that have been isolated for hundreds of generations form a new hybrid population. Currently, interest in measuring biogeographic ancestry has spread from anthropology to forensic sciences, direct-to-consumers personal genomics, and civil rights issues of minorities, a.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr911
- DOI:
- 10.4238/vol9-4gmr911
Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in an Indian population
Authors: P.N. Mukhopadhyaya, A. Acharya, Y. Chavan, S.S. Purohit and A. Mutha
A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females)... Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr883
- DOI:
- 10.4238/vol9-4gmr883
Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study
Authors: A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, L.B. Ferreira, G.S. Lordelo, J.G.M. Melo, C.K. Grisolia, S.F. Oliveira and M.N. Klautau-Guimar�£es
Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigate.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr973
- DOI:
- 10.4238/vol9-4gmr973
Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer
Authors: W.W. Jiang, Q.H. Wang, P. Peng, Y.J. Liao, H.X. Duan, M. Xu, Y. Li and P.B. Zhang
We explored the effects of flurbiprofen axetil on interleukin (IL)-2 and IL-6 levels in postoperative patients with colorectal cancer. A total of 120 patients (American Society of Anesthesiologists I and II) scheduled to undergo colorectal cancer surgery were randomly divided into 3 groups (N = 40 in each group): flurbiprofen axetil group (group F), morph.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients
Authors: B. Sun, J. Li, M. Dong, L. Yang, C. Wu, L. Zhu and Y.L. Cong
We investigated the correlation between genetic polymorphisms of cytochrome P450 enzyme genes and the outcome of clopidogrel treatment in 118 coronary disease patients after percutaneous coronary intervention at the Chinese PLA General Hospital. Patients were divided into an ischemia event relapse group (IERG) and a non-IERG group (NIERG) based on relapse.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.22
- DOI:
- 10.4238/2015.February.13.22
Retrospective analysis of pathologic nipple discharge
Authors: L. Yang, D. Wu and Z.-M. Fan
The cause of pathologic nipple discharge is mainly benign lesions, but there is still a possibility of malignancy. Pathologic nipple discharge may be the only or the first symptom of breast cancer. This study aimed to investigate the clinical factors associated with lesions in patients with pathologic nipple discharge using a retrospective analysis of cli.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.23
- DOI:
- 10.4238/2015.February.13.23
Genetic diversity analysis of Capparis spinosa L. populations by using ISSR markers
Authors: C. Liu, G.P. Xue, B. Cheng, X. Wang, J. He, G.H. Liu and W.J. Yang
Capparis spinosa L. is an important medicinal species in the Xinjiang Province of China. Ten natural populations of C. spinosa from 3 locations in North, Central, and South Xinjiang were studied using morphological trait inter simple sequence repeat (ISSR) molecular markers to assess the genetic diversity and population structure. In this study, the 10 IS.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Effectiveness evaluation of dendritic cell immunotherapy for osteosarcoma on survival rate and in vitro immune response
Authors: X. Fang, C. Jiang and Q. Xia
The aim of this study was to investigate the effects of dendritic cell (DC) therapy in osteosarcoma. Bone marrow DCs from Wistar (allograft group) and Sprague Dawley (SD) (homograft group) rats were electrically fused with the SD-derived osteosarcoma cell line UMR106 to generate a DC-osteosarcoma fusion (DOF) tumor vaccine, wh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.10
- DOI:
- 10.4238/2015.October.2.10