Human Genetics
Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha
Authors: L.J. Qin, T. Zhang, Y.S. Jia, Y.B. Zhang, Y.X. Zhang and H.T. Wang
Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.11
- DOI:
- 10.4238/2015.October.2.11
Up-regulation of Id1 in peripheral blood of psoriatic patients
Authors: C. Ronpirin, M. Achariyakul, T. Tencomnao, J. Wongpiyabovorn and W. Chaicumpa
Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of th.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr963
- DOI:
- 10.4238/vol9-4gmr963
Clinical applications of internal heat source analysis for breast cancer identification
Authors: F. Han, C.W. Liang, G.L. Shi, L. Wang and K.Y. Li
Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.24
- DOI:
- 10.4238/2015.February.13.24
Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population
Authors: Q. Qadri, A.S. Sameer, Z.A. Shah, A. Hamid, S. Alam, S. Manzoor and M.A. Siddiqi
Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investig.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.6.4
- DOI:
- 10.4238/2011.December.6.4
Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease
Authors: J.Y. Zhong, X.W. Zheng, H.D. Ye, H.B. Cui, W.P. Du, Z.X. Zhang, X.H. Fei, S.Y. Lin, J. Wang, J. Su, X.M. Chen and S.W. Duan
APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.8
- DOI:
- 10.4238/2015.October.2.8
Biosom: gene synonym analysis by self-organizing map
Authors: K.R. Otemaier, M.B.R. Steffens, R.T. Raittz, A. Brawerman and J.N. Marchaukoski
There are several guidelines for gene nomenclature, but they are not always applied to the names of newly identified genes. The lack of standardization in naming genes generates inconsistent databases with errors such as genes with the same function and different names, genes with different functions and the same name, and use of an abbreviated name. This.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.1
- DOI:
- 10.4238/2015.February.20.1
Cytogenetic findings in Serbian patients with Turnerâ??s syndrome stigmata
Authors: V.A. Djordjevi??, J.V. Jovanovi??, S.B. Pavkovi??-Lu?i??, D.D. Drakuli??, M.M. Djurovi?? and M.D. Goti??
Cytogenetic findings are reported for 31 female patients with Turner’s syndrome. Chromosome studies were made from lymphocyte cultures. Non-mosaicism 45,X was demonstrated in 15 of these patients, whereas only three were apparently mosaic. Eight patients showed non-mosaic and four patients showed mosaic structural aberra.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr953
- DOI:
- 10.4238/vol9-4gmr953
Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk
Authors: F. Ghasemvand, E. Omidinia, Z. Salehi and S. Rahmanzadeh
Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.14
- DOI:
- 10.4238/2015.October.2.14
Effect of p53 gene polymorphism on functions of prostate cancer cells
Authors: N. Chi, Z.Z. Yun, Z.H. Tan, X.Z. Li, B.T.B.G. Chen, J. Liu, L.B. Xu, K.W. Ma, S.X. Li, J.F. Liu and C.X. Liu
Prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcDNA3.1-p53 (V/V), mutant type pcDNA3.1- p53 (G/G)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. Empty plasmids containing wild-type pcDNA3.1-p53 (V/V) and mutant type pcDNA3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.3
- DOI:
- 10.4238/2015.October.2.3
Multivariate analysis of molecular markers in peripheral blood associated with recurrence and metastasis of hepatocellular carcinoma
Authors: X.J. Liu, B. Wang, W.G. Jiang, Y.J. Li, J.B. Liu and M. Zhang
Invasion, metastasis, and recurrence are the most common causes of death in patients with hepatocellular carcinoma (HCC) and are therefore critical factors for both therapy and prognosis. Current methods for diagnosis of HCC rely mainly on serological markers such as alpha-fetoprotein and liver enzymes, together with physical assessment and imaging techni.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.5
- DOI:
- 10.4238/2015.February.20.5