Human Genetics
Interaction between CYP 2C19*3 polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han population
Authors: J. Feng, L. Li, Y.-S. Zhao, S.-Q. Tang, H.-B. Yang and S.-X. Liu
Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which strongly promote proliferation of cancer cells in vitro and in vivo. Knowing that smoking is the most important risk factor for laryngeal carcinoma, we examined the relationships between CYP2C19*3 polymorphism, smoki.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.9
- DOI:
- 10.4238/2011.December.5.9
GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr971
- DOI:
- 10.4238/vol9-4gmr971
Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women
Authors: Z.S. ��zkan, D. Deveci, E. ��nalan Etem and H. Y�¼ce
We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women wi.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr922
- DOI:
- 10.4238/vol9-4gmr922
Expression of claudin-1 and its relationship with lymphatic microvessel generation in hypopharyngeal squamous cell carcinoma
Authors: W.J. Li1,, Z.L. Zhang, X.M. Yu, X.L. Cai, X.L. Pan and X.Y. Yang
We investigated the relationship between claudin-1 and micro-lymphatic vessel density (MLVD) by detecting claudin-1 and protein D2-40 expression in cancer tissue specimens obtained from 97 patients with hypopharyngeal squamous cell carcinoma (HSCC). We also explored the correlation between the expression of these proteins and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.15
- DOI:
- 10.4238/2015.October.2.15
Quantitation of glucocorticoid receptor alpha and NF-�ºB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients
Authors: L.O. Cavalcante, M.R. Melo, V.G. Dinis, R.B. Castro, B.D.B. Souza and C.A. Longui
We measured NF-κB, IKK, c-Fos, and GRα mRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr970
- DOI:
- 10.4238/vol9-4gmr970
Clinical significance of fibroblast growth factor receptor-3 mutations in bladder cancer: a systematic review and meta-analysis
Authors: X. Liu, W. Zhang, D. Geng, J. He, Y. Zhao and L. Yu
Mutations in the fibroblast growth factor receptor-3 (FGFR3) gene are frequently found in bladder cancer, but their prognostic value remains controversial. To globally summarize the association between FGFR3 mutations and the grade and stage of bladder cancer, and to analyze the predictive role of FGFR3 mutations with respect .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.12
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.12
IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis
Authors: X.B. Bao, Z. Ma, J.B. Gu, X.Q. Wang, H.G. Li and W.Y. Wang
We conducted a case-control study to clarify the associations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634 C/G (rs1800796), IL-8 -251T/A (rs407.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.6
- DOI:
- 10.4238/2015.February.20.6
Development of a DNA-based vaccine strategy against bovine papillomavirus infection, involving the E5 or L2 gene
Authors: E.G. Lima, R.C. Lira, A.L.S. Jesus, R. Dhalia and A.C. Freitas
Papillomaviruses are known to cause tumor lesions, generally benign, in epithelial tissues of diverse organisms; these lesions may progress to cancer under suitable conditions. Bovine papillomavirus (BPV) can cause urinary bladder cancer and cancer of the upper gastrointestinal tract. Furthermore, BPV1 and BPV2 are implicated .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.13
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.13
An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population
Authors: T. Tencomnao and J. Wongpiyabovorn
The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr920
- DOI:
- 10.4238/vol9-4gmr920
Prevalence of CCR5-Ã?Â?32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil
Authors: H. Ferreira-Fernandes, A.C.C. Santos, F.J.N. Motta, R. Canalle, F.K.N. Yoshioka, R.R. Burbano, J.A. Rey, B.B. da Silva and G.R. Pinto
Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-Δ32 and CCR2-V64I are related to human immunodeficiency virus infection resis.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.4
- DOI:
- 10.4238/2015.October.2.4