Human Genetics
1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients
Authors: S.A. Gutierrez-Rubio, A. Quintero-Ramos, A. Dur�¡n-C�¡rdenas,R.A. Franco-Topete, J.M. Castro-Cervantes, A. Oceguera-Villanueva, L.M. Jim�©nez-P�©rez, L.M.A. Balderas-Pe�±a, G. Morgan-Villela,A. Del-Toro-Arreola and A. Daneri-Navarro
MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.3
- DOI:
- 10.4238/2015.February.13.3
Effect of nimodipine on rat spinal cord injury
Authors: Y.-F. Jia, H.-L. Gao, L.-J. Ma and J. Li
We evaluated the potentially protective effect of nimodipine on rat spinal cord injury. Sprague-Dawley rats received spinal cord injury, and were separated into nimodipine (N = 12) and saline groups (N = 12). Within 1 h of the injury, rats were treated intraperitoneally with nimodipine (1.0 mg/kg) or an equal amount of saline. Treatment was performed 3 ti.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.5
- DOI:
- 10.4238/2015.February.13.5
Association between B7-H1 expression and bladder cancer: a meta-analysis
Authors: Y.U. Wang, A.N.G. Liu and S.H.A.N. Zhao
B7 homolog 1 (B7-H1), which is also known as programmed death-L1, is an important member of the B7/CD28 costimulatory factor superfamily, which are emerging as important mediators of various host immune responses. B7-H1 is differentially expressed in various cell subsets and to different extents in human and murine cells. Human B7-H1 is constitutively exp.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.6
- DOI:
- 10.4238/2015.February.13.6
Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer
Authors: Y. Li, H.Z. Qin, Q. Song, X.D. Wu and J.H. Zhu
Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis
Authors: W. Deng, J.C. Han, L. Chen and W.L. Qi
Numerous studies have evaluated the association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis to examine the association between the ESR1 gene PvuII polymorphism and fracture risk in postmenopausal women. Studies published fro.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.8
- DOI:
- 10.4238/2015.February.13.8
Clinical application of three-dimensional reconstruction and rapid prototyping technology of multislice spiral computed tomography angiography for the repair of ventricular septal defect of tetralogy of Fallot
Authors: X.J. Ma, L. Tao, X. Chen, W. Li, Z.Y. Peng, Y. Chen, J. Jin,X.L. Zhang, Q.F. Xiong, Z.L. Zhon and X.F. Chen
Three-dimensional (3D) reconstruction and rapid proÃ?Âtotyping technology (RPT) of multislice spiral computed tomography angiography (CTA) was applied to prepare physical models of the heart and ventricular septal defects of tetralogy of Fallot (ToF) patients in order to explore their applications in the diagnosis and treatment of this complex heart disease.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.9
- DOI:
- 10.4238/2015.February.13.9
Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis
Authors: Z.Y. Gao, X.Y. Li, V. Bhandari, L.D. Li and D. Lan
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome involving a final common pathway of hypercytokinemia, in which tumor necrosis factor (TNF)-a, interferon (IFN)-g, and soluble interleukin 2-receptor-alpha (sIL-2Ra) are the key cytokines. Pre-B-cell colony-enhancing factor (PBEF) is an inflammatory cytokine involved in several inflamm.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.21
- DOI:
- 10.4238/2015.May.18.21
Clinical reports and analysis of patients with clinical manifestations of migraine-like headache and unruptured aneurysm
Authors: M. Zhao
A retrospective analysis of three cases of clinical manifestations of migraine-like headache, including clinical features, imaging findings, and follow-up results was done to explore the potential correlation between migraine and unruptured aneurysm. Clinical data and digital subtraction angiography (DSA) results were retrospectively analyzed. All three p.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.10
- DOI:
- 10.4238/2015.February.13.10
Tissue culture characteristics of maize (Zea mays L.) haploid coleoptile sections
Authors: L. Jiang, G.X. Jing, X.Y. Li, X.Q. Wang, Z. Xing, P.K. Deng and R.G. Zhao
Doubled haploid (DH) technology, which is used for rapidly purifying genetic resources, is a key technology in modern maize breeding. The present study evaluated the tissue culture characteristics of maize haploid coleoptile sections, in order to provide a new way of haploid doubling. With 20 combinations of haploid coleoptile sections, obtained by hybrid.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Establishment of a neuroblastoma mouse model by subcutaneous xenograft transplantation and its use to study metastatic neuroblastoma
Authors: Q. Gao, C.F. Chen, Q. Dong, L. Hou, X. Chen, Y.L. Zhi, X. Li, H.T. Lu and H.Y. Zhang
The aim of this study was to establish a metastatic human neuroblastoma (NB) mouse model by xenograft in order to study the metastatic mechanisms of NB. A human NB cell line was obtained from a 5-year-old patient and cultured in vitro. A suspension of these cells was subcutaneously inoculated into nude mice at the right flank next to the forelimb. The bio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015