Human Genetics
Clinical three-dimensional conformal radiotherapy research using repeated computed tomography scans for field reduction in older non-small-cell lung cancer patients
Authors: Z.Z. Fu, T. Gu, S.H. Zhang, X.Y. Cao, Q.H. Zhang, Y.Q. Zhang, H.X. Hua, S. Yang, P. Li and Z. Zhang
This study investigated the curative and toxic effects of three-dimensional conformal radiotherapy (3D-CRT), using repeated CT scans for field reduction in older non-small-cell lung cancer (NSCLC) patients. 3D-CRT was administered to 36 older patients with NSCLC, and irradiation fields included the primary lesion and metastati.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.13
- DOI:
- 10.4238/2014.July.24.13
Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort
Authors: Z. Li, W.T. Yuan, S.J. Ning and S.J. Zhang
The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender- and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.18
- DOI:
- 10.4238/2014.July.24.18
Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang
Authors: L. Zhang, J. Sun, J.Q. Zhang, M. Yang, G. Bai and X.L. Ma
This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esoph.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.21
- DOI:
- 10.4238/2014.July.24.21
Association of dietary intake of folate and MTHFR genotype with breast cancer risk
Authors: Z.G. Wang, W. Cui, L.F. Yang, Y.Q. Zhu and W.H. Wei
We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.24
- DOI:
- 10.4238/2014.July.24.24
Clinical significance of interleukin-4 and interleukin-18 levels in aggressive non-Hodgkin�s lymphoma patients
Authors: H.O. Soydinc, N. Guney, M. Basaran, D. Duranyildiz and V. Yasasever
Strong evidence indicates that tumor growth can be actively controlled by the immune system, and interleukins (ILs) are known to play an influential role in immune response regulation. Moreover, inflammatory cytokines are significantly involved in lymphoma pathogenesis. We aimed to investigate serum levels of IL-4 and IL-18 in aggressive non-Hodgkin&rsquo.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038590
- DOI:
- 10.4238/gmr.15038590
Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population
Authors: W.M. Zhao, P. Shayimu, L. Liu, F. Fang and X.L. Huang
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospital-based case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 20.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037864
- DOI:
- 10.4238/gmr.15037864
Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes
Authors: L. Yang, S.J. Chen, G.Y. Yuan, D. Wang and J.J. Chen
We investigated serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes (T2DM) and explored the association between vaspin and body mass index, age, gender, glucose, lipid metabolism, and insulin sensitivity. Fasting serum vaspin levels in 66 patients with T2DM and 48 n.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.September.25.2
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.2
Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study
Authors: H.Y. Yang, S.Y. Chuang, W.H. Fang, G.S. Huang, C.C. Wang, Y.Y. Huang, M.Y. Chu, C. Lin, W. Su, C.Y. Chen, Y.T. Yang and S.L. Su
Recent studies have revealed that the inflammatory process plays a role in the pathogenesis of osteoarthritis (OA). The S100 family and receptor for advanced glycation end products (RAGE)participate in regulating inflammation, even in the production of matrix metalloproteinases (MMPs). MMP-1 degrades cartilage, which may result in OA development. Moreover.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.25.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.3
Molecular typing of Salmonella from Sergipe, Northeastern Brazil, showing the epidemiological relationship between poultry and human infection
Authors: P.B.P. G�³is, M.R.P. Carneiro, S. Jain, M.I.S. Santos, M.V.A. Batista and A.L. C�¢ndido
Randomly amplified polymorphic DNA (RAPD) has been widely used for epidemiological and phylogenetic purposes owing to its rapidity and efficiency. The aim of this study was to perform genome typing of Salmonella samples isolated from different sources by RAPD profiling. Thirty-three Salmonella samples from the bacterial collection of the Laboratóri.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.25.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.6
Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis
Authors: Y. Liu, M.C. Yu, A.Q. Zhang, Y.B. Wang, K. Jiang and J.H. Dong
We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.1
- DOI:
- 10.4238/2015.February.13.1