Human Genetics

Effect of ultraviolet A exposure on transport of compatible organic osmolytes in human lens epithelial cells

Authors: D.Y. Wu and J.S. Zhang

Compatible organic osmolytes, such as betaine, myoinositol, and taurine, are involved in antioxidant defense, protein stabilization, and stress responses. This osmolyte strategy requires the expression of specific osmolyte transporters such as betaine (BGT-1), myoinositol (SMIT), and taurine (TAUT). In contrast to the kidney, keratinocytes, and neural cel.. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.3

DOI:

10.4238/2015.May.18.3

Association between the interleukin 4 gene -590C>T promoter polymorphism and asthma in Xinjiang Uighur children

Authors: J.H. Zhang, G.H. Zhou, T.T. Wei and Z.S. Chang

We investigated the association between the interleukin 4 gene (IL-4) -590C>T polymorphism and forced expiratory volume in one second (FEV1) values, immunoglobulin E (IgE) levels, and susceptibility to asthma in Uighur children. IL-4 -590C>T frequencies were analyzed in 38 bronchial asthmatic patients and 35 non-asthmatic controls. Polymerase chain .. Read More»

Genet. Mol. Res. 15(3):

gmr.15038363

DOI:

10.4238/gmr.15038363

Abnormal expression of PTEN and PIK3CA in pemetrexed-resistant human pancreatic cancer cell line Patu8988

Authors: X. Shi, H.T. Gu, S.B. Lin, Y. Zhang, J. Yang and C.J. Qian

The aim of this study was to investigate the expression of PTEN and PIK3CA in the pemetrexed-resistant human pancreatic cancer cell line Patu8988, and to evaluate their effects on the biological behavior of pancreatic cancer cells. PTEN and PIK3CA gene and protein expressions were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and we.. Read More»

Genet. Mol. Res. 15(3):

gmr.15036991

DOI:

10.4238/gmr.15036991

Association between rs9904341 G

.. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.10

DOI:

10.4238/2015.May.18.10

Association of NF-�ºB1 gene polymorphisms with coronary artery disease in a Han Chinese population

Authors: X.L. Guo, X.C. Liu, G.B. Su, C.Y. Zhou and Q.T. Cui

Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038072

DOI:

10.4238/gmr.15038072

Expression profiles of genes associated with mitochondria-mediated apoptosis and their roles in liver regeneration

Authors: X.K. Xing, M.H. Li, Z.W. Guo and C.S. Xu

Mitochondria are closely associated with cell survival, and it is of interest to determine whether apoptosis pathways, which are mediated by mitochondria, are involved in liver regeneration (LR). To identify the mechanisms underlying mitochondria-mediated apoptosis during rat LR, we used the Rat Genome 230 2.0 Array to investigate changes in gene expressi.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038101

DOI:

10.4238/gmr.15038101

Effect of calcitonin on anastrozole-induced bone pain during aromatase inhibitor therapy for breast cancer

Authors: P. Liu, D.Q. Yang, F. Xie, B. Zhou and M. Liu

This study aimed to investigate calcitonin as an effective therapy for osteoporosis in patients with bone pain during the anastrozole treatment of breast cancer. Ninety-one patients, who were on anastrozole treatment for breast cancer and also suffered anastrozole-induced bone pain, were randomly divided into two groups: the c.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.7

DOI:

10.4238/2014.July.24.7

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Authors: F. Yan, R. Wang and L. Geng

Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible st.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038172

DOI:

10.4238/gmr.15038172

CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis

Authors: X. Wang and Y. He

Cytochrome P4502E1 (CYP2E1) is a key enzyme in the metabolic activation of many carcinogens, but the roles of CYP2E1 polymorphisms in cervical neoplasia (CN) are inconclusive. Published case-control cohort studies from the Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios with .. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.11

DOI:

10.4238/2015.May.18.11

Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania

Authors: E. Marku, P.E. Maltese, M. Koni, N. Capodicasa, I.S. Qendro, E. Rigoni, S. Cecchin and M. Bertelli

Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are.. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.13

DOI:

10.4238/2015.May.18.13