Bioinformatics
Bicluster and regulatory network analysis of differentially expressed genes in adenocarcinoma and squamous cell carcinoma
Authors: L. Li, J. Zhu, S.-X. Guo and Y. Deng
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung cancer (NSCLC). Although differences in molecular, histological, and clinical characteristics have been reported for both subtypes, no specific therapy exists thus far. The aim of this analysis was to identify potential therapeutic target genes th.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.2
- DOI:
- 10.4238/2013.May.21.2
Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis
Authors: X. Lu, X.D. Lv, Y.H. Ren, W.D. Yang, Z.B. Li, L. Zhang and X.F. Bai
Despite extensive research, the prognosis of high-grade glioblastoma multiforme (GBM) has improved only slightly because of the limited response to standard treatments. Recent advances (discoveries of molecular biomarkers) provide new opportunities for the treatment of GBM. The aim of the present study was to identify diagnost.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027646
- DOI:
- 10.4238/gmr.15027646
Prediction of maize double-cross hybrids using the best linear unbiased prediction with microsatellite marker information
Authors: M. Balestre, R.G. Von Pinho and J.C. Souza
We examined the usefulness of the best linear unbiased prediction associated with molecular markers for prediction of untested maize double-cross hybrids. Ten single-cross hybrids from different commercial backgrounds were crossed using a complete diallel design. These 10 single-cross hybrids were genotyped with 20 microsatell.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr985
- DOI:
- 10.4238/vol10-1gmr985
Estimating genetic potential of biofuel forest hardwoods to withstand metal toxicity in industrial effluent under dry tropical conditions
Authors: S.A. Manzoor, S.N. Mirza, M. Zubair, W. Nouman, S.B. Hussain, S. Mehmood, A. Irshad, N. Sarwar, A. Ammar, M.F. Iqbal, A. Asim, M.U. Chattha, M.B. Chattha, A. Zafar and R. Abid
Biofuel tree species are recognized as a promising alternative source of fuel to conventional forms. Additionally, thesetree species are also effective in accumulating toxic heavy metals present in some industrial effluents. In developing countries such as Pakistan, the use of biofuel tree species is gaining popularity not only for harvesting economical a.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.17
- DOI:
- 10.4238/2015.August.14.17
Estimation of genetic distance based on RAPDs between 11 cotton accessions varying in heat tolerance
Authors: A.I. Khan, I.A. Khan, F.S. Awan, H.A. Sadaqat and S. Bahadur
The genetic distance of 11 cotton genotypes varying in heat tolerance was studied using RAPD markers. Fifty-three random decamer primers were used for the estimation of genetic distance. Among the 53 RAPD primers, which were custom synthesized by GeneLink Inc., UK, 32 were polymorphic and 21 were monomorphic. The 32 polymorphi.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr835
- DOI:
- 10.4238/vol10-1gmr835
Isolation and characterization of eight novel microsatellite markers in Acanthopagrus schlegelii
Authors: X.Q. Mao, Z.B. Li, Y. Yuan, Y.F. Ning, J.B. Shangguan,Y.S. Huang, M Yang and B.B. Li
Acanthopagrus schlegelii is a warm temperate demersal fish, which inhabits the sediment substrate or rocky reefs in shallow seas. As this fish is a nutritionally endowed species with good palatability, it is a highly valuable commercial species for aquaculture and has a long historical standing in Western Pacific countries. Be.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027902
- DOI:
- 10.4238/gmr.15027902
Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide
Authors: M.C. Rios, W.R.T. Silva, A.F. Azevedo, P.L. Santos, S.A. Teixeira, M.N. Muscar�¡, S.M. Thomazzi, R.P. Almeida, R.P.M. Fernandesand R. Scher
Leishmania spp are the causative agents of a spectrum of diseases termed leishmaniasis that affect mammals, including humans and dogs. Although reactive nitrogen species are employed in the control of parasitism by the immune system, it is known that Leishmania can withstand this oxidative stress. As the mechanism by which these species are resistant to n.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.4
- DOI:
- 10.4238/2015.June.29.4
Reaction norms for the study of genotype environment interaction for growth and indicator traits of sexual precocity in Nellore cattle
Authors: M.V.A. Lemos, H.L.J. Chiaia, M.P. Berton, F.L.B. Feitosa, C. Aboujaoude,G.C. Venturini, H.N. Oliveira, L.G. Albuquerque and F. Baldi
The objective of this study was to quantify the magnitude of genotype-environment interaction (GxE) effects on age at first calving (AFC), scrotal circumference (SC), and yearling weight (YW) in Nellore cattle using reaction norms. For the study, 89,152 weight records of female and male Nellore animals obtained at yearling age were used. Genetic parameter.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.9
- DOI:
- 10.4238/2015.June.29.9
Bayesian forecasting of temporal gene expression by using an auto regressive panel data approach
Authors: M. Nascimento, F.F. e Silva, T. S�¡fadi, A.C.C. Nascimento, L.M.A. Barroso, L.S. Gl�³ria and B. de S. Carvalho
We propose and evaluate a novel approach for forecasting gene expression over non-observed times in longitudinal trials under a Bayesian viewpoint. One of the aims is to cluster genes that share similar expression patterns over time and then use this similarity to predict relative expression at time points of interest. Express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027299
- DOI:
- 10.4238/gmr.15027299
Potential hippocampal genes and pathways involved in Alzheimer�s disease:a bioinformatic analysis
Authors: L. Zhang, X.Q. Guo, J.F. Chu, X. Zhang, Z.R. Yan and Y.Z. Li
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly people. Numerous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four t.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.15
- DOI:
- 10.4238/2015.June.29.15