Bioinformatics
Differential gene expression in pre-laying and laying period ovaries of Sichuan White geese (Anser cygnoides)
Authors: N. Ding, Q. Han, X.Z. Zhao, Q. Li, J. Li, H.F. Zhang, G.L. Gao,Y. Luo, Y.H. Xie, J. Su and Q.G. Wang
Geese are an economically important poultry species worldwide. Their superior meat production performance and meat quality make them a popular food. However, they are not bred worldwide because their poor laying capacity increases farming costs. To gain a global view of the genes that are differentially expressed between prelaying (P) and laying (L) perio.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.20
- DOI:
- 10.4238/2015.June.18.20
Development of microsatellite markers for a hard-shelled mussel, Mytilus coruscus, and cross-species transfer
Authors: J.H. Kang, Y.K. Kim, J.Y. Park, E.S. Noh, J.E. Jeong, Y.S. Lee and T.J. Choi
The Korean mussel Mytilus coruscus, an endemic marine bivalve mollusk, is economically important. Its population is currently decreasing due to overexploitation and invasion of a more competitive species, Mytilus galloprovincialis. In this study, microsatellite markers for M. coruscus were developed using a cost-effective pyrosequencing technique. Among t.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.2
- DOI:
- 10.4238/2013.September.27.2
Genetic analysis of differentiation of T-helper lymphocytes
Authors: Q. Wang, M. Li, L.C. Xia, G. Wen, H. Zu and M. Gao
In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3. We developed a system dynamics mod.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.13
- DOI:
- 10.4238/2013.April.2.13
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
Comparative multiplex dosage analysis in spinocerebellar ataxia type 2 patients
Authors: F. Cal�¬, V. Chiavetta, A. Ragalmuto, M. Vinci, G. Ruggeri, P. Schinocca and V. Romano
We developed a new application of comparative multiplex dosage analysis (CMDA) for evaluation of the ataxin 2 gene. Expansions of the triplet CAG can cause spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disease with an autosomal-dominant mode of inheritance. Molecular diagnosis of SCA2 is routinely based on the use of conventional PCR to detect.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.4
- DOI:
- 10.4238/2013.April.12.4
Construction of a gene-gene interaction network with a combined score across multiple approaches
Authors: A.M. Zhang, H. Song, Y.H. Shen and Y. Liu
Recent progress in computational methods for investigating physical and functional gene interactions has provided new insights into the complexity of biological processes. An essential part of these methods is presented visually in the form of gene interaction networks that can be valuable in exploring the mechanisms of disease. Here, a combined network b.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.11
- DOI:
- 10.4238/2015.June.26.11
Paeonia (Paeoniaceae) expressed sequence tag-derived microsatellite markers transferred to Paeonia delavayi
Authors: D.X. Wang, H. Ma, Y.L. Zhang, A.A. Duan, W.J. Li and Z.H. Li
Paeonia Franchet contains approximately 30 species of perennial herbs and is the only member of the family Paeoniaceae. Paeonia delavayi is an endangered ornamental plant that has a compound flower color and is endemic to southwest China. Its optimal habitats have been fragmented and its population size has greatly decreased as a result of human activitie.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.17.6
- DOI:
- 10.4238/2013.April.17.6
Text-mining network analysis of the response to osmotic stimuli in the intervertebral disc
Authors: X. Xu, L. Liu and Q.Y. Lu
Intervertebral disc cells experience a broad range of physical stimuli under physiologic conditions, including alterations in their osmotic environment. The purpose of this study was to construct a text-mining network of the genes induced during the response to osmotic stimuli in the intervertebral disc. We obtained a gene expression profile of human inte.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.11
- DOI:
- 10.4238/2013.May.13.11
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
Application of denaturing gradient gel electrophoresis for detection of bacterial and yeast communities along a salinity gradient in the estuary of the Cachoeira River in Brazil
Authors: C.S.P. Rodrigues, S.S. Souza, R.P. Rezende, A. Silva, J.L. Andrioli, H. Costa, R. Fontana and J.C.T. Dias
An estuary is a transition zone between freshwater and marine ecosystems, resulting in dilution of seawater. Estuaries are also considered environments of intense biological activity related to the processes of nutrient cycling. The aim of this study was to evaluate the microbial community composition along a salinity gradient in the estuary of the Cachoe.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.6
- DOI:
- 10.4238/2013.May.21.6