Bioinformatics
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.22
- DOI:
- 10.4238/2013.January.4.22
Identifying the molecular basis of functions in the transcriptome of the social amoeba Dictyostelium discoideum
Authors: T.J. Whitney, D.G. Gardner, M.L. Mott and M. Brandon
The unusual life cycle of Dictyostelium discoideum, in which an extra-cellular stressor such as starvation induces the development of a multicellular fruiting body consisting of stalk cells and spores from a culture of identical amoebae, provides an excellent model for investigating the molecular control of differentiation and.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr752
- DOI:
- 10.4238/vol9-1gmr752
Overexpression of type-A rice response regulators, OsRR3 and OsRR5, results in lower sensitivity to cytokinins
Authors: X. Cheng*, H. Jiang*, J. Zhang, Y. Qian, S. Zhu and B. Cheng
Response regulators are part of a two-component regulatory system. The type-A Arabidopsis response regulators act as negative regulators. To understand the function of type-A response regulators in the model monocot plant, rice (Japonica cultivar-group: Zhonghua11), we overexpressed two type-A OsRR genes, OsRR3 and OsRR5 (pACT.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr739
- DOI:
- 10.4238/vol9-1gmr739
Isolation and identification of new pollen-specific SFB genes in Japanese apricot (Prunus mume)
Authors: P.P. Wang, Z.H. Gao, Z.J. Ni, W.B. Zhuang and Z. Zhang
SFB, a candidate gene for the pollen S gene, has been identified in several species of Prunus (Rosaceae). We isolated 5 new SFB alleles from 6 Japanese apricot (Prunus mume) lines using a specific Prunus SFB primer pair (SFB-C1F and Pm-Vb), which was designed from conserved regions of Prunus SFB. The nucleotide sequences of these SFB genes were submitted .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.5
- DOI:
- 10.4238/2013.September.3.5
Simple-sequence repeat markers of Cattleya coccinea (Orchidaceae), an endangered species of the Brazilian Atlantic Forest
Authors: M. Novello, J.F. Rodrigues, F. Pinheiro, G.C.X. Oliveira, E.A. Veasey and S. Koehler
Microsatellite markers were developed for the endangered Brazilian orchid species Cattleya coccinea to describe its genetic diversity and structure and to support conservation studies. Nine microsatellite loci were isolated and characterized using an enriched genomic library. All loci are polymorphic at least in the 2 populations sampled, except for loci .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.3
- DOI:
- 10.4238/2013.September.3.3
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Authors: M.Y. Yu, P.Q. Zhao, X.H. Yan, B. Liu, Q.Q. Zhang, R. Wang, C.H. Ma, X.H. Liang, F.L. Zhu and L.F. Gao
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recent.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.10.2
- DOI:
- 10.4238/2013.September.10.2
Development of polymorphic microsatellite markers for Dioscorea zingiberensis and cross-amplification in other Dioscorea species
Authors: Q.-Q. Yan, X.-Q. Sun, J.-L. Guo, Y.-Y. Hang and M.-M. Li
Dioscorea zingiberensis C.H. Wright (Dioscoreaceae) is an endemic species in central and southwestern China. In order to study the genetic diversity and population structure of this species, 19 novel polymorphic microsatellite loci were developed using a dual-suppression PCR technique. The number of alleles per locus ranged from 3 to 21, with an average o.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.10
- DOI:
- 10.4238/2013.September.19.10
IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil
Authors: I.A. Pess�´a, F.E.S. Sagica, N.P. Anselmo, J.R.N. Brito an E.H.C. de Oliveira
Glioma is a term used to describe tumors derived from glial cells. These tumors are divided into subgroups based on the histological morphology and similarity of their differentiated glia cells. Traditionally, they are classified according to the World Health Organization and include astrocytomas, oligodendrogliomas, ependymomas, and oligoastrocytomas. Li.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.6
- DOI:
- 10.4238/2015.June.12.6
Partial least squares-based gene expression analysis in preeclampsia
Authors: F. Jiang, Y. Yang, J. Li, W. Li, Y. Luo, Y. Li, H. Zhao, X. Wang, G. Yin and G. Wu
Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.2
- DOI:
- 10.4238/2015.June.18.2
Multi-objective optimization in systematic conservation planning and the representation of genetic variability among populations
Authors: S. Schlottfeldt, M.E.M.T. Walter, A.C.P. L.F. Carvalho, T.N. Soares, M.P.C. Telles, R.D. Loyola and J.A.F. Diniz-Filho
Biodiversity crises have led scientists to develop strategies for achieving conservation goals. The underlying principle of these strategies lies in systematic conservation planning (SCP), in which there are at least 2 conflicting objectives, making it a good candidate for multi-objective optimization. Although SCP is typically applied at the species leve.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.18
- DOI:
- 10.4238/2015.June.18.18