Bioinformatics
Association of variable number of tandem repeat polymorphism in the IL-4 gene with ischemic stroke in the Chinese Uyghur population
Authors: Y.-Q. Tong, J.-J. Ye, Z.-H. Wang, Y.-W. Zhang, F.-X. Zhan, X.-H. Guan, Y.-J. Geng, S.-Y. Hou, Y. Li, J.-Q.Cheng, Z.-X. Lu and J.-F. Liu
Ischemic stroke (IS) is a multifactorial disorder, and genetic factors act as important contributors to its onset and progression. Inflammation is a key event that is closely associated with the pathophysiology of IS. The association of genetic polymorphisms of inflammatory cytokines with IS remains poorly understood. We investigated the relationship betw.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.May.13.2
- DOI:
- 10.4238/2013.May.13.2
Development and characterization of microsatellite loci in a threatened marine fish, Cheilinus undulatus (humphead wrasse)
Authors: J. Hu, X.P. Zhu, J. Luo, S.W. Yin, Y.H. Peng, Y.L. Hu and F. Zhu
Cheilinus undulatus (humphead wrasse) is a marine fish distributed widely throughout the tropical Indo-Pacific. It has been listed as vulnerable in the IUCN Red Data Book and in CITES Appendix II four times. Fifteen microsatellite loci were isolated and characterized for this species. The number of alleles ranged from 3 to 15 per locus, and the observed a.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.2
- DOI:
- 10.4238/2013.July.30.2
3p partial trisomy and 13q partial monosomy with congenital malformations and psychomotor developmental delay
Authors: M.J. Rodovalho-Doriqui, P.L. Freitas, J.D. Pinho, L.R. Cavalli and S.R.F. Pereira
We examined a girl presenting neuropsychomotor developmental delay and multiple malformations including antenatal and postnatal growth retardation, congenital heart defect, and facial dysmorphisms. Cytogenetic analysis was performed on peripheral blood lymphocytes with the GTG-banding technique, which revealed an unbalanced translocation: 46,XX,der(13)(13.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.7
- DOI:
- 10.4238/2013.July.24.7
Characterization of new microsatellite markers of Siganus fuscescens (Siganidae)
Authors: Q.H. Li, Z.B. Li, G. Dai, X.J. Chen, L.N. Chen, Y.Y. Cao, J.B. Shangguan and Y.F. Ning
Siganus fuscescens, which is a small commercially important marine fish, is wildly distributed in shallow waters throughout the tropical and subtropical Indo-Pacific and Eastern Mediterranean regions. It is part of a group known as rabbitfish. Fifteen new polymorphic microsatellite markers for S. fuscescens were identified, and 32 wild individuals were us.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.12
- DOI:
- 10.4238/2013.July.30.12
Development of microsatellite markers for Mytilus coruscus (Mytilidae), an economically important mussel in the East China Sea
Authors: B.-Y. Guo, C.-W. Wu, C.-L. Liu, A.-Y. Zhu and Y.-Y. Ye
Twelve new polymorphic microsatellite loci were developed for the hard-shelled mussel, Mytilus coruscus. In 32 individuals from a wild population of coastal Zhoushan, Zhejiang Province, China, the number of alleles at these loci varied from 3 to 15, with a mean of 5.667. The mean observed and expected heterozygosities were 0.6927 and 0.6591, respectively... Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.5
- DOI:
- 10.4238/2013.July.30.5
Survey of simple sequence repeats in woodland strawberry (Fragaria vesca)
Authors: L. Guan, J.F. Huang, G.Q. Feng, X.W. Wang, Y. Wang, B.Y. Chen and Y.S. Qiao
The use of simple sequence repeats (SSRs), or microsatellites, as genetic markers has become popular due to their abundance and variation in length among individuals. In this study, we investigated linkage groups (LGs) in the woodland strawberry (Fragaria vesca) and demonstrated variation in the abundances, densities, and relative densities of mononucleot.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.3
- DOI:
- 10.4238/2013.July.30.3
Significance of linkage disequilibrium heterogeneous patterns in the 21q22.3 region for mapping 21 trisomy individualsv
Authors: Y. Valle, J.R. Padilla-GutiÃ?©rrez, A. Quintero-Ramos, I.J. GarcÃ?Âa-GonzÃ?¡lez and F. Rivas
Recombination patterns can be indirectly inferred by means of linkage disequilibrium (LD) estimates, since LD is negatively correlated with genetic distance. However, LD does not necessarily have absolute correspondence with genetic distance. We estimated LD at 5 loci located in the 21q22.3 region. These STRs (D21S1440, D21S168, D21S1260, D21S1446, and D2.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.8.2
- DOI:
- 10.4238/2013.August.8.2
Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools
Authors: H.X. Wang and Y.X. Zhao
The aim of this study was to identify potential markers of atherosclerosis development in familial hypercholesterolemia (FH) patients. GSE13985 microarray data, generated using blood samples from 5 FH patients and 5 matched controls, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027347
- DOI:
- 10.4238/gmr.15027347
Bioinformatic analysis based on the complete coding region of the MSTN gene within and among different species
Authors: X.C. Song, C. Xu, Z.G. Yue, L. Wang, G.W. Wang and F.H. Yang
Myostatin, encoded by the MSTN gene (previously GDF8), is a member of the transforming growth factor-β superfamily, which normally acts to limit skeletal muscle mass by regulating the number and growth of muscle fibers. In this study, a total of 84 myostatin gene sequences with known complete coding regions (CDS) and corr.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025031
- DOI:
- 10.4238/gmr.15025031
Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes
Authors: L.J. Qin, Y. Lv and Q.Y. Huang
KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11) and ABCC8 (ATP-binding cassette, subfamily C (CFTR/MRP), member 8) have been studied for association with type 2 diabetes in various ethnic populations with contradictory results. We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evalua.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.1
- DOI:
- 10.4238/2013.August.20.1