Bioinformatics
Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro
Authors: C. Ronpirin and T. Tencomnao
Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in rapid proliferation of keratinocytes and incomplete keratini.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.17.3
- DOI:
- 10.4238/2012.February.17.3
Proapoptotic effects of heme oxygenase-1 inhibitor on Kasumi-1 cells via the ATF4/ CHOP/Ire-1�± pathway
Authors: S.-X. Wei, Y.-T. Wang, Q.-X. Chai, Q. Fang, Y.-M. Zhang and J.-S. Wang
We evaluated the effects of down-regulated heme oxygenase (HO)-1 expression on the proliferation of the acute myelocytic leukemia Kasumi-1 cell line by using the HO-1 inhibitor zinc protoporphyrin IX (ZnPPIX) in combination with daunorubicin (DNR), and evaluated the mechanism. The proliferation rates of cells treated with 10 mg/mL DNR and 10 mM ZnPPIX ind.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.17
- DOI:
- 10.4238/2015.June.1.17
Impact of enteral nutrition on postoperative immune function and nutritional status
Authors: F. Wang, M.X. Hou, X.L. Wu, L.D. Bao and P.D. Dong
We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surger.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.4
- DOI:
- 10.4238/2015.June.8.4
Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression
Authors: L.N. Kong, D.X. Zhang, C.L. Ji, X.Q. Zhang and Q.B. Luo
Glucose-regulated protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum and can be induced by different kinds of environmental and physiological stress. Thus far, the role of the GRP78 gene in thermotolerance in chickens has not been investigated. In the present study, we detected sequence variations in the 5êÃ?Â?Ã?Â?-flanking reg.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.9
- DOI:
- 10.4238/2015.June.8.9
Application of vacuum-assisted closure in seawater-immersed wound treatment under different negative pressures
Authors: L. Cao, M.M. Peng, J.J. Sun, X.C. Yu and B. Shi
The therapeutic effect of vacuum-assisted closure (VAC) has been confirmed in many types of complex wounds, but there are few relevant reports regarding seawater-immersed wounds. The aim of this study was to determine the effect of VAC on seawater-immersed wound healing under different negative pressures and explore the optimal negative pressure value. Fo.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.12
- DOI:
- 10.4238/2015.June.8.12
Is the optimal intervention policy UC superior to the suboptimal policy MFPT over inferred probabilistic Boolean network models?
Authors: X.Z. Zan, W.B. Liu, M.X. Hu and L.Z. Shen
A salient problem in translational genomics is the use of gene regulatory networks to determine therapeutic intervention strategies. Theoretically, in a complete network, the optimal policy performs better than the suboptimal policy. However, this theory may not hold if we intervene in a system based on a control policy derive.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049334
- DOI:
- 10.4238/gmr15049334
Use of microsatellite markers in molecular analysis of segregating populations of papaya (Carica papaya L.) derived from backcrossing
Authors: F.O. Pinto, M.G. Pereira, L.N. Luz, D.L. Cardozo, H.C.C. Ramos and C.M.P. Macedo
Brazil is the world leader in papaya production. However, only a small number of cultivars are registered for commercial planting, mainly owing to delays in obtaining cultivars and the high costs of the field phase of breeding programs. These costs can be reduced when molecular tools are combined with conventional breeding methods. In the present study, w.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.6
- DOI:
- 10.4238/2013.July.8.6
Construction and analysis of a subtractive cDNA library of early embryonic development in duck
Authors: Y.L. Liu, L.X. Zhong, J.J. Li, J.D. Shen, D.Q. Wang, Z.R. Tao, F.X. Shi and L.Z. Lu
Several studies have documented the process of early embryonic development in poultry; however, the molecular mechanisms underlying its developmental regulation are poorly understood, particularly in ducks. In this study, we analyzed differential gene expression of embryos 6 and 25 h following oviposition to determine which genes regulate the early develo.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.5
- DOI:
- 10.4238/2013.July.8.5
Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer
Authors: D.S. Vasconcelos, F.P.E. da Silva, L.G. Quintana, N.P. Anselmo, M.A.K. Othman, T. Liehr and E.H.C. de Oliveira
Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor ge.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.15
- DOI:
- 10.4238/2013.January.4.15
Factors influencing QTL mapping accuracy under complicated genetic models by computer simulation
Authors: C.F. Su, W. Wang, S.L. Gong, J.H. Zuo and S.J. Li
The accuracy of quantitative trait loci (QTLs) identified using different sample sizes and marker densities was evaluated in different genetic models. Model I assumed one additive QTL; Model II assumed three additive QTLs plus one pair of epistatic QTLs; and Model III assumed two additive QTLs with opposite genetic effects plu.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049153
- DOI:
- 10.4238/gmr15049153