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Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039697
- DOI:
- 10.4238/gmr16039697
QTLs of morpho-agronomic traits in the Jalo x Small White common bean population
Authors: D.A. Souza, M. Balestre, A.K.A. Pamplona, L.R. Pinheiro, F.C. Alves, D.R. Pereira and J.B. Santos
In this study, we aimed to estimate the relationship between some common bean traits using molecular markers and applying QTL mapping. We used a segregating population derived from a crossing between common bean cultivars, Jalo and Small White, in the Southern State of Minas Gerais. Of F2 plants, 190 F2:3 progenies were genera.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039686
- DOI:
- 10.4238/gmr16039686
Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand
Authors: A. Tungtrongchitr, J. Jumpasri, N. Sookrung, N. Visitsunthorn, P. Tantilipikorn, O. Piboonpocanan, N. Indrawattana, R. Tungtrongchitr and W. Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled st.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039641
- DOI:
- 10.4238/gmr16039641
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population
Authors: Z. Fang, M. Li, Z. Ma and G. Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16037446
- DOI:
- 10.4238/gmr16037446
Promoter identification and analysis of key glycosphingolipid biosynthesis-globo series pathway genes in piglets
Authors: W.Y. Qin, L.N. Gan, R.W. Xia, W.H. Dong, S.Y. Sun, G.Q. Zhu,S.L. Wu and W.B. Bao
Glycosphingolipid biosynthesis-globo series pathway genes (FUT1, FUT2, ST3GAL1, HEXA, HEXB, B3GALNT1, and NAGA) play an important regulatory role in the defense against Escherichia coli F18 in piglets. In this study, we identified the transcription initiation site and promoter of this gene cluster by mined previous RNA-seq res.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029574
- DOI:
- 10.4238/gmr16029574
Artificial neural networks as auxiliary tools for the improvement of bean plant architecture
Authors: V.Q. Carneiro, G.N. Silva, C.D. Cruz, P.C.S Carneiro, M. Nascimento and J.E.S. Carneiro
lassification using a scale of visual notes is a strategy used to select erect bean plants in order to improve bean plant architectures. Use of morphological traits associated with the phenotypic expression of bean architecture in classification procedures may enhance selection. The objective of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029500
- DOI:
- 10.4238/gmr16029500
Transferability of microsatellite markers in Syagrus coronata (Mart.) Becc. (Arecaceae), an iconic palm tree from the Brazilian semiarid region
Authors: R.R. Simplicio, D.G. Pereira and A.M. Waldschmidt
The licuri palm Syagrus coronata plays a key role in the ecology and economy of Brazilian semiarid region. Nonetheless, genetic data about populations of this species are absent even though the intensive and uncontrolled exploitation since colonial periods has threatened the sustainability and viability of licuri populations. .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029699
- DOI:
- 10.4238/gmr16029699
Haplotypes and polymorphism in the CCR5 gene in sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira, J.C. Silva Junior and A.A.L. Barbosa
Sickle cell disease shows several clinical manifestations in distinct levels of severity. This heterogeneity is due to the haplotype variability associated with the HbS gene, levels of fetal hemoglobin and environmental conditions, which modify the disease expression. Science community believes that the presence of a polymorph.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029675
- DOI:
- 10.4238/gmr16029675
Genome-wide analysis of salinity-stress induced DNA methylation alterations in cotton (Gossypium hirsutum L.) using the Me-DIP sequencing technology
Authors: X.K. Lu, N. Shu, J.J. Wang, X.G. Chen, D.L. Wang, S. Wang, W.L. Fan, X.N. Guo, L.X. Guo and W.W. Ye
Cytosine DNA methylation is a significant form of DNA modification closely associated with gene expression in eukaryotes, fungi, animals, and plants. Although the reference genomes of cotton (Gossypium hirsutum L.) have been publically available, the salinity-stress-induced DNA methylome alterations in cotton are not well unde.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029673
- DOI:
- 10.4238/gmr16029673
Phenotypic and genotypic correlations between soybean agronomic traits and path analysis
Authors: B.Q.V. Machado, A.P.O. Nogueira, O.T. Hamawaki, G.F. Rezende, G.L. Jorge, I.C. Silveira, L.A. Medeiros, R.L. Hamawaki and C.D.L. Hamawaki
The goals of this research were to evaluate the phenotypic and genotypic correlations between agronomic traits, to perform path analysis, having as main character grain yield, and to identify indirect selection criteria for grain yield. The experiment was carried out in an experimental area located at Capim Branco farm, which .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029696
- DOI:
- 10.4238/gmr16029696