HLA-B35, a common genetic trait, in a familial case of Henoch-Schoenlein purpura and Berger�s disease
Authors: M.C. Pellegrin, L. Matarazzo, E. Neri, M. Pennesi and S. Crovella
Nephritis characterized by IgA mesangial depositions has been described both in Henoch-Schoenlein purpura (HSP) and in Berger’s disease (BD), but common genetic traits are still uncertain. We report here the case of two brothers, the first affected by HSP with persistent nephritis and the second by BD, accidentally disco.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.9
- DOI:
- 10.4238/2014.April.8.9
Cytogenetic and molecular identification of a wheat-Leymus mollis alien multiple substitution line from octoploid Tritileymus x Triticum durum
Authors: Y.H. Pang, J.X. Zhao, W.L. Du, Y.L. Li, J. Wang, L.M. Wang, J. Wu, X.N. Cheng, Q.H. Yang and X.H. Chen
Leymus mollis (Trin.) Pilger (NsNsXmXm, 2n = 28), a wild relative of common wheat, possesses many traits that are potentially valuable for wheat improvement. In order to exploit and utilize the useful genes of L. mollis, we developed a multiple alien substitution line, 10DM50, from the progenies of octoploid Tritileymus M842-1.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.1
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.1
Prognostic implication of molecular aberrations in cytogenetically normal acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation
Authors: Y.C. Liu1,2,3*, H.H. Hsiao1,2*, P.M. Lin4, W.C. Yang1,3, C.S. Chang1,2, T.C. Liu1,3, J.F. Hsu1, M.Y. Yang5 and S.F. Lin1,2
Different molecular aberrations can be discriminated into certain prognostic subgroups in cytogenetically normal acute myeloid leukemia (CN-AML) patients but their impact on allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial and studies from Asian populations are lacking. Forty-two adult non-M3 AML patients receiving allo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.11.3
- DOI:
- 10.4238/2013.November.11.3
Molecular characterization by amplified ribosomal DNA restriction analysis and antimicrobial potential of endophytic fungi isolated from Luehea divaricata (Malvaceae) against plant pathogenic fungi and pathogenic bacteria
Authors: J. Bernardi-Wenzel1, A. Garcia2, J.L. Azevedo2 and J.A. Pamphile2
Luehea divaricata is an important plant in popular medicine; it is used for its depurative, anti-inflammatory, and other therapeutic activities. We evaluated the antimicrobial activity of endophytic fungi isolated from leaves of L. divaricata against phytopathogens and pathogenic bacteria, and characterized the isolates based on amplified ribosomal DNA re.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.2
- DOI:
- 10.4238/2013.October.29.2
Expression of ADAMTS4 and ADAMTS5 in longissimus dorsi muscle related to meat tenderness in Nanyang cattle
Authors: X.H. Zhang, Y.X. Qi, X. Gao, J.Y. Li and S.Z. Xu
The ADAMTS4 and ADAMTS5 are secreted proteases, which can cleave aggrecan, brevican and versican to regulate rebuilding of the extracellular matrix. We analyzed the ADAMTS4 and ADAMTS5 gene expression patterns in longissimus dorsi muscle at intervals from 135 days fetal age to 30 months old by qRT-PCR in Nanyang cattle. Expression of ADAMTS4 was significa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.2
- DOI:
- 10.4238/2013.October.18.2
Analysis of differentially expressed genes in malignant biliary strictures
Authors: D.C. Qi, B. Wu, S.L. Tao, J. Zhou, H.X. Qian and D. Wang
Microarray data were collected from bile duct samples from subjects with malignant biliary strictures by endoscopic retrograde cholangiopancreatography to screen for key genes associated with this disease. A predicted interaction network was constructed for these genes to interpret their functions. The gene expression dataset .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.10
- DOI:
- 10.4238/2014.April.8.10
Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukin 8 of vascular smooth muscle cells
Authors: H.-P. Tang1*, L.-X. Sun2* and W. Han1*
The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vascular smooth muscle cells (VSMCs). Cultured lung microvascular endothelial cells were treated with or without tumor necrosis factor alpha (TNF-α; 10 ng/mL) for 6 h, and the supernatant was collected and filtered. The superna.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.2
- DOI:
- 10.4238/2013.October.10.2
Study of white matter at the centrum semiovale level with magnetic resonance spectroscopy and diffusion tensor imaging in cerebral small vessel disease
Authors: L.A. Huang, X.Y. Ling, C. Li, S.J. Zhang, G.B. Chi and A.D. Xu
White matter lesion (WML) in magnetic resonance imaging is commonly observed in patients with cerebral small vessel disease (SVD), but the pathological mechanism of WML in SVD is still unclear. We observed the metabolism and microscopic anatomy of white matter in SVD patients. Twelve subjects clinically diagnosed with SVD and .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.11
- DOI:
- 10.4238/2014.April.8.11
Identification of spliced mRNA isoforms of retinoid X receptor (RXR) in the Oriental freshwater prawn Macrobrachium nipponense
Authors: Z. Li, W.Q. Wang, E.F. Zhang and G.F. Qiu
Retinoid X receptors (RXR) are members of the nuclear receptor family that are conserved from invertebrates to vertebrates, and they play an essential role in regulating reproductive maturation, molting, and embryo development. In this study, fi ve RXR isoforms, named RXRL2 (L, long form), RXRL3, RXRS1 (S, short form), RXRS2, .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.2
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.2
Analysis of GATA1 mutations and leukemogenesis in newborns with Down syndrome
Authors: L.B. Queiroz, B.D. Lima, J.F. Mazzeu, R. Camargo, M.S. C�³rdoba, I.Q. Magalh�£es, C. Martins-de-S�¡ and I. Ferrari
It has been reported that patients with Down syndrome (DS) frequently develop transient myeloproliferative disorder (TMD) and less commonly myeloid leukemia in DS (ML-DS). We examined the pathogenetic relationship of these conditions with somatic mutations of the GATA1 gene in children with both TMD and ML-DS. To determine the incidence of GATA1 mutations.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.1
- DOI:
- 10.4238/2013.October.18.1