Table of Contents | Genet. Mol. Res.2017(1)
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
Genet. Mol. Res. 16(1): gmr16019411
DOI: 10.4238/gmr16019411
miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2
Authors: C.Y. He and J. Yang
Cervical carcinoma is a life-threatening illness posing considerable danger to women’s health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence .. Read More»
Genet. Mol. Res. 16(1): gmr16018969
DOI: 10.4238/gmr16018969
Marker-trait association analysis for agronomic and compositional traits in sainfoin (Onobrychis viciifolia)
Authors: K. Kempf, C.S. Malisch, C. Grieder, F. Widmer and R. K�¶lliker
Sainfoin (Onobrychis viciifolia) is a perennial forage legume with great potential for use in sustainable agriculture due to its low input requirements, good drought tolerance, and production of forage rich in polyphenolic compounds, which are beneficial for animal health. However, its distribution and cultivation are limited .. Read More»
Genet. Mol. Res. 16(1): gmr16019483
DOI: 10.4238/gmr16019483
Analysis of specific serum markers of colon carcinoma using a Bhattacharyya-based support vector machine
Authors: W.Y. Yang, G. Shi, L.P. Wu, S.T. Wei, Y.N. Huang, L.X. Tan, R.Z. Yang, C.X. Yan, E.T. Guo, H.Y. Wang, J.Z. Tong, Y. Dong and D.Z. Han
We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of.. Read More»
Genet. Mol. Res. 16(1): gmr16019521
DOI: 10.4238/gmr16019521
Role of inosine triphosphate pyrophosphatase gene variant on fever incidence during zidovudine antiretroviral therapy
Authors: A.V.C. Coelho, S.P.S. Silva, L. Zandon� , G. Stocco, G. Decorti and S. Crovella
Zidovudine, the antiretroviral drug used to treat HIV infection, commonly causes adverse effects, such as systemic fever and gastrointestinal alterations. In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) o.. Read More»
Genet. Mol. Res. 16(1): gmr16019373
DOI: 10.4238/gmr16019373
Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample
Authors: C. VÃ?¡zquez, M. Orlova, P. Scibona, H. DÃ?Âaz Arce, M.G. Pallotta and W.H. Belloso
Thymidylate synthase (TYMS) is a key enzyme in nucleotide synthesis and therefore, an important target of many chemotherapeutic agents. Expression of TYMS mRNA is thought to be modulated by a 28-bp tandem repeat polymorphism within its 5'-untranslated region, raising the question of this variant’s utility in predicting t.. Read More»
Genet. Mol. Res. 16(1): gmr16019367
DOI: 10.4238/gmr16019367
Genetic progress estimation strategy for upright common bean plants using recurrent selection
Authors: L.A. Pereira, A.F.B. Abreu, I.C. Vieira J�ºnior, L.P.M. Pires,M.A.P. Ramalho
Common bean producers in Brazil tend to grow plants as upright as possible. Because the control of this trait involves a large number of genes, recurrent selection (RS) is the best approach for successful plant improvement. Because plant architecture (PA) is evaluated using scores and usually has high heritability, RS for PA i.. Read More»
Genet. Mol. Res. 16(1): gmr16019494
DOI: 10.4238/gmr16019494
Prevention of DNA damage and anticarcinogenic activity of Activia�® in a preclinical model
Authors: S.M.A. Limeiras, F.M. Ogo, L.A.L. Genez, C.M. Carreira,E.J.T. Oliveira, L.R. Pessatto, S.C. Neves, J.R. Pesarini, L.C. Schweich, R.A. Silva, W.B. Cantero, A.C.M.B. Antoniolli-Silva, R.J. Oliveira
Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria comb.. Read More»
Genet. Mol. Res. 16(1): gmr16019492
DOI: 10.4238/gmr16019492