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Z. Fang

Publications of : Z. Fang
Human Genetics   Research Article

Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population

Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, two single nucleotide polymorphisms in ED.. Read More»

Genet. Mol. Res. 16(3): gmr16037446

DOI: 10.4238/gmr16037446

Human Genetics   Research Article

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

    H. Wang Y. Zhao J. Ma G. Zhang Y. Mu G. Qi Z. Fang L. Wang Q. Fan Z. Ma

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, that is.. Read More»

Genet. Mol. Res. 12(1): 2013.January.22.5

DOI: 10.4238/2013.January.22.5

Human Genetics   Research Article

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

    M. Jargosch, S. Kröger, E. Gralinska, U. Klotz, Z. Fang, W. Chen, U. Leser, J. Selbig, D. Groth and R. Baumgrass

Data integration has become a useful strategy for uncovering new insights into complex biological networks. We studied whether this approach can help to delineate the signal transducer and activator of transcription 6 (STAT6)-mediated transcriptional network driving T helper (Th) 2 cell fate decisions. To this end, we performed an integrative analysis of publicly av.. Read More»

Genet. Mol. Res. 15(2): gmr.15028493

DOI: 10.4238/gmr.15028493

Medical Genetics   Research Article

Clinical effects and safety review of self-expanding stent surgery for extracranial carotid artery stenosis treatment

    Q.F. Zhu, S.Z. Fang, G.F. Wang, Z.Z. Zhou, S.C. Bian, S.D. Cui, S.B. Yu, F.W. Wang, L.B. Shan and J. Kang

This study aimed to investigate the clinical effects and safety review of self-expanding stent surgery in the treatment of extracranial carotid artery stenosis. Seventy-eight patients with carotid artery stenosis were applied with the self-expanding stent for endovascular interventional therapy. Eighty-one stents were implanted into 80 blood vessels of the 78 patien.. Read More»

Genet. Mol. Res. 13(3): 2014.July.7.5

DOI: 10.4238/2014.July.7.5

Medical Genetics   Research Article

Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma

    S. Wang, Y. Huang, R. Su, Z. Fang and M. Han

Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains poorl.. Read More»

Genet. Mol. Res. 14(2): 2015.June.1.2

DOI: 10.4238/2015.June.1.2