Microbial Genetics
Polymorphisms of GSTM1, GSTT1, and p53 in Goi�¢nia, Goi�¡s
Authors: D.A. Rodrigues, I.R. Costa, J.V.M. Martins, K.S.F. e Silva and K.K.V.O. Moura
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested tha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.4
- DOI:
- 10.4238/2015.December.21.4
Resistance of upland-rice lines to root-knot nematode, Meloidogyne incognita
Authors: D.C.T. Souza, F.B.S. Botelho, C.S. Rodrigues, I.V. Furtini, E.C. Smiderle, D.L. de Matos and A.T. Bruzi
Despite the benefits of crop rotation, occurrence of nematodes is a common problem for almost all crops within the Cerrado biome, especially for rice. The use of resistant cultivars is one of the main methods for control of nematodes. Thus, the present study aimed to evaluate the reaction of 36 upland-rice lines, with desirable agronomic characteristics, .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.7
- DOI:
- 10.4238/2015.December.21.7
Cloning and characterization of a novel betaine aldehyde dehydrogenase gene from Suaeda corniculata
Authors: F.W. Wang, M.L. Wang, C. Guo, N. Wang, X.W. Li, H. Chen,Y.Y. Dong, X.F. Chen, Z.M. Wang and H.Y. Li
Glycine betaine is an important quaternary ammonium compound that is produced in response to several abiotic stresses in many organisms. The synthesis of glycine betaine requires the catalysis of betaine aldehyde dehydrogenase (BADH), which can convert betaine aldehyde into glycine betaine in plants, especially in halotolerant.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027848
- DOI:
- 10.4238/gmr.15027848
Endophytic and pathogenic isolates of the cacao fungal pathogen Moniliophthora perniciosa (Tricholomataceae) are indistinguishable based on genetic and physiological analysis
Authors: T.G. Lana, J.L. Azevedo, A.W.V. Pomella, R.T.R. Monteiro, C.B. Silva and W.L. Ara�ºjo
We evaluated the genetic and physiological variability of Moniliophthora perniciosa obtained from healthy and diseased branches of cacao (Theobroma cacao) plants. The diversity of the isolates was evaluated by RAPD technique and by studies of virulence and exoenzyme production. The genetic variability of endophytic and pathogenic M. perniciosa was evaluat.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr895
- DOI:
- 10.4238/vol10-1gmr895
Pathogenicity for onion and genetic diversity of isolates of the pathogenic fungus Colletotrichum gloeosporioides (Phyllachoraceae) from the State of Pernambuco, Brazil
Authors: M.X. Vila Nova, L.R. Borges, A.C.B. de Sousa, B.T.R.V. Brasileiro, E.A.L.A. Lima, A.F. da Costa and N.T. de Oliveira
Onion anthracnose, caused by Colletotrichum gloeosporioides, is one of the main diseases of onions in the State of Pernambuco. We examined the pathogenicity of 15 C. gloeosporioides strains and analyzed their genetic variability using RAPDs and internal transcribed spacers (ITS) of the rDNA region. Ten of the strains were obta.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1014
- DOI:
- 10.4238/vol10-1gmr1014
Silencing effect of lentiviral vectors encoding shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages
Authors: F.L. Chen, Q. Li, J.Y. Zhang1,, L.J. Lei, Z. Zhang, T.N. Mahmoud, X.G. Wang, P.F. Lin, Y.P. Jin and A.H. Wang
Herp, a mammalian protein with a ubiquitin-like domain, can be strongly upregulated by endoplasmic reticulum (ER) stress during ER-associated protein degradation. However, the other cellular functions of Herp remain unclear. We explored the effect of Herp on ER stress and inflammatory responses in RAW 264.7 macrophages that had been exposed to tunicamycin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.31
- DOI:
- 10.4238/2015.December.21.31
Clinical significance of microRNA-34a in esophageal squamous cell carcinoma
Authors: X. Lin, X.Y. Xu, Q.S. Chen and C. Huang
MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation. However, the clinical significance and prognostic value of miR-34a in ESCC has not yet been investigated. In to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.41
- DOI:
- 10.4238/2015.December.21.41
Mitochondrial transfer RNA mutations and hypertension
Authors: S.L. Yin, C. Lan, H. Pei, and Z.Q. Zhu
Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.42
- DOI:
- 10.4238/2015.December.21.42
Coexpression of interleukin-6 and -2 from giant panda in Escherichia coli and the biological activity of the fusion protein
Authors: Y. Yi, Y.-Y. Nian, H.-W. Ji, H. Zhang, L. Zhu and Z.-W. Xu
To construct a fusion cytokine protein with more and stronger bioactivities to enhance the immunity of the cytokine alone, we expressed interleukin (IL)-6/(IL)-2 from giant panda (Ailuropoda melanoleuca) in Escherichia coli as a 59.4-kDa fusion protein. Subsequently, the inclusion bodies were solubilized with 8 M urea and applied onto a Ni-nitrilotriaceti.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.14.1
- DOI:
- 10.4238/2013.June.14.1
Selecting key genes associated with osteosarcoma based on a differential expression network
Authors: Y.B. Wang, N. Jia, C.M. Xu, L. Zhao, Y. Zhao, X. Wang and T.H. Jia
Despite recent advances in osteosarcoma diagnosis and therapy, much remains unclear about the molecular mechanisms involved in the disorder, and the discovery of novel drug-targeted genes is essential. We explored the potential molecular mechanisms and target genes involved in the development and progression of osteosarcoma. First, we identified the diffe.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.44
- DOI:
- 10.4238/2015.December.21.44