Microbial Genetics
Prediction of core cancer genes using a hybrid of feature selection and machine learning methods
Authors: Y.X. Liu, N.N. Zhang, Y. He and L.J. Lun
Machine learning techniques are of great importance in the analysis of microarray expression data, and provide a systematic and promising way to predict core cancer genes. In this study, a hybrid strategy was introduced based on machine learning techniques to select a small set of informative genes, which will lead to improving classification accuracy. Fi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.10
- DOI:
- 10.4238/2015.August.3.10
Effect of montelukast on the expression of interleukin-18, telomerase reverse transcriptase, and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage
Authors: J.L. Liu, X.H. Zhao, D.L. Zhang, J.B. Zhang and Z.H. Liu
The aim of this study was to investigate the effect of montelukast on the expression of interleukin (IL)-18, telomerase reverse transcriptase (TERT), and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage (HIBD). To establish the model of HIBD, 8% oxygen was applied to rats after the unilateral carotid artery was ligated. Twenty.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.13
- DOI:
- 10.4238/2015.August.3.13
Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis
Authors: Y. Zhang, Y.F. Yu, J.Z. Wang and H. Jia
This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.14
- DOI:
- 10.4238/2015.August.3.14
Role of adiponectin in adipose tissue wound healing
Authors: C.E. Jin, L. Xiao, Z.H. Ge, X.B. Zhan and H.X. Zhou
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.11
- DOI:
- 10.4238/2015.August.3.11
Biogeographic pattern of genetic diversity detected by RAPD and ISSR analysis in Gypsophila (Caryophyllaceae) species from Turkey
Authors: M. Korkmaz and N.Y. Dogan
Gypsophila L. is the 3rd-largest genus of Caryophyllaceae in Turkey, a country that includes 60 taxa belonging to 56 species of the 126 recognized in the genus. A total of 35 taxa are endemic to Turkey, with an approximately 60% endemism ratio. In this study, the genetic diversity of 14 Gypsophila species from Turkey was analyzed using random amplificatio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.6
- DOI:
- 10.4238/2015.August.3.6
Impact of adherence to GOLD guidelines on 6-minute walk distance, MRC dyspnea scale score, lung function decline, quality of life, and quality-adjusted life years in a Shanghai suburb
Authors: Y.Q. Jiang, Y.X. Zhu, X.L. Chen, X. Xu, F. Li, H.J. Fu, C.Y. Shen, Y.Y. Lu, Q.J. Zhuang, G. Xu, Y.Y. Cai, Y. Zhang, S.S. Liu, M.Y. Zhu and S.H. Li
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructivepulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.9
- DOI:
- 10.4238/2015.August.3.9
Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet �² cells
Authors: Y. Qin, L. Xiao, X.B. Zhan and H.X. Zhou
The pancreatic and duodenal homeobox factor 1 (Pdx1) protein is the most pivotal transcription factor in the development of islet β cells. This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet β cells. iPSCs derived from human skin fibroblasts were cultured in vitro and di.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.12
- DOI:
- 10.4238/2015.August.3.12
Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome
Authors: L. Sun, J.Y. Liu and L.R. Li
Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.15
- DOI:
- 10.4238/2015.August.3.15
Characterization of microsatellite markers and their correlations with growth traits in Mandarin fish (Siniperca chuatsi)
Authors: T.L. Yi, L. Fang, X.F. Liang, L.F. Sun, J. Li, X.N. Luo, W.J. Guo, Y.Q. Dou and J. Sun
Mandarin fish (Siniperca chuatsi) is a traditionally cultured freshwater fish with high commercial value in China. To facilitate marker-assisted selection for genetic improvement of this species, 100 microsatellite markers identifi ed in previous studies were characterized in the 25 largest and 25 smallest individuals. Twenty polymorphic loci were used to.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.1
- DOI:
- 10.4238/2015.August.7.1
Analysis of genetic diversity identified by amplified fragment length polymorphism marker in hybrid wheat
Authors: M. Ejaz, Z. Qidi, Z. Gaisheng, N. Na, Z. Huiyan and W. Qunzhu
Amplified fragment length polymorphism markers were used to assess genetic diversity in 10 male sterile wheat crop lines (hetero-cytoplasm with the same nucleus) in relation to a restorer wheat line. These male sterile lines were evaluated using 64 amplified fragment length polymorphism primer combinations, and 13 primers produced polymorphic bands, gener.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.2
- DOI:
- 10.4238/2015.August.7.2