Microbial Genetics
Isolation and analysis of �±-expansin genes in the tree Anthocephalus chinensis (Rubiaceae)
Authors: K.X. Ouyang, M.Q. Liu, R.Q. Pian, S.S. Liu and X.Y. Chen
Expansins are cell wall-associated proteins that induce wall extension and relax stress by disrupting noncovalent bonds between cellulose microfibrils and cross-linking glycan chains, thereby promoting wall creep. Anthocephalus chinensis is a very fast-growing economically important tree found mainly in South Asia. Sixteen cDNAs, designated AcEXPA1 to AcE.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.2
- DOI:
- 10.4238/2013.April.10.2
Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma
Authors: Y.W. Sun, Q. Xuan, Q.A. Shu, S.S. Wu, H. Chen, J. Xiao, P. Xiang, Y.P. Zhu, F.L. Wang and S.T. Zhao
Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer. We analyzed the expression of survivin and VEGF in paraffin-embedded tumor tissues from 78 patients with bladder transitional cell carcinoma (BTCC) using an immunohistochemistry method. Normal bladder mucosae from 10 non-BTCC c.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.21
- DOI:
- 10.4238/2013.April.2.21
Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies
Authors: Y.Z. Li, L.J. Wang, X. Li, S.L. Li, J.L. Wang, Z.H. Wu, L. Gong and X.D. Zhang
Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.20
- DOI:
- 10.4238/2013.April.2.20
Sequence analysis of the regulatory region of the TNF-RII gene in Polish Holstein-Friesian cows
Authors: A. Stachura, E. Kaczmarczyk and B. BojarojÃ?Â?-Nosowicz
Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body’s immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.19
- DOI:
- 10.4238/2013.April.2.19
Nucleotide mismatches of foot-and-mouth disease virus during replication
Authors: Y.B. Ma, C.X. Hao and H.Y. Chang
As there is a lack of error correction mechanisms during RNA replication, foot-and-mouth disease virus (FMDV) has a very high mismatch rate, which leads to a high mutation rate, in the range of 10-3 to 10-5 per nucleotide site per genome replication. We examined the nucleotide mismatch of FMDV during replication, based on the whole genomes of the 7 seroty.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.18
- DOI:
- 10.4238/2013.April.2.18
MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3
Authors: L. He, H. Yao, L.H. Fan, L. Liu, S. Qiu, X. Li, J.P. Gao and C.Q. Hao
We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.17
- DOI:
- 10.4238/2013.April.2.17
Protein expression levels in the medullary visceral zone of rats with subarachnoid hemorrhage
Authors: L.H. Sun, L.F. Xing, G.H. Zhang and S.Y. Pan
We investigated protein expression in the medullary visceral zone (MVZ) of rats with multiple-organ dysfunction syndrome (MODS) caused by subarachnoid hemorrhage (SAH) to discuss the possible regulatory mechanism of the MVZ in the course of SAH-induced MODS. A SAH-induced MODS model was established in rats by injecting arterial blood into the Willis&rsquo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.7
- DOI:
- 10.4238/2015.August.3.7
Characterization and expression analysis of the prophenoloxidase activating factor from the mud crab Scylla paramamosain
Authors: J. Wang, K.J. Jiang, F.Y. Zhang, W. Song, M. Zhao, H.Q. Wei, Y.Y. Meng and L.B. Ma
Prophenoloxidase activating factors (PPAFs) are a group of clip domain serine proteinases that can convert prophenoloxidase (pro-PO) to the active form of phenoloxidase (PO), causing melanization of pathogens. Here, two full-length PPAF cDNAs from Scylla paramamosain (SpPPAF1 and SpPPAF2) were cloned and characterized. The full-length SpPPAF1 cDNA was 167.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.8
- DOI:
- 10.4238/2015.August.3.8
Characterization and effects of miR-21 expression in esophageal cancer
Authors: S.-W. Wen, Y.-F. Zhang, Y. Li, Z.-X. Liu, H.-L. Lv, Z.-H. Li, Y.-Z. Xu, Y.-G. Zhu and Z.-Q. Tian
The aim of this study was to investigate the expression of miR-21 in esophageal cancer and the impact of miR-21 on apoptosis, invasion, and the expression of target genes in esophageal cancer cells. Fluorescence quantitative polymerase chain reaction analysis was used to detect the expression of miR-21 in human esophageal tissues, adjacent tissues, and an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.4
- DOI:
- 10.4238/2015.August.3.4
Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes
Authors: J. Wang, T. Zou, H.X. Yang, Y.Z. Gong, X.J. Xie, H.Y. Liu and D.F. Liao
Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.5
- DOI:
- 10.4238/2015.August.3.5