Microbial Genetics
Polymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility
Authors: L. Zhu
We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.19
- DOI:
- 10.4238/2015.July.28.19
Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis
Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou
Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.4
- DOI:
- 10.4238/2015.July.28.4
Identification of heat shock proteins via transcriptome profiling of tree peony leaf exposed to high temperature
Authors: Y.Z. Zhang, Y.W. Cheng, H.Y. Ya*, J.M. Han and L. Zheng
The tree peony leaf is an important vegetative organ that is sensitive to abiotic stress and particularly to high temperature. This sensitivity affects plant growth and restricts tree peony distribution. However, the transcriptomic information currently available on the peony leaf in public databases is limited. In this study, we sequenced the transcripto.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.10
- DOI:
- 10.4238/2015.July.28.10
Promoter and first exon methylation regulate porcine FASN gene expression
Authors: K.R. Long, J.D. Ma, L. Chen, P.J. Wang, D.F. He, M.Z. Li and X.W. Li
DNA methylation is a stable epigenetic mark mediating gene expression. Methylation is crucial for diverse biological processes, including aging and embryo development. FASN (fatty acid synthase) plays an important role in de novo lipogenesis, through catalyzing the reductive synthesis of long-chain fatty acids. In this study, we investigated the FASN gene.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.11
- DOI:
- 10.4238/2015.July.28.11
Immune memory responses to HBV vaccine 13-18 years after primary vaccination
Authors: L. Hou, W. Li, X. Wei, Y. Zhou, Y. Zhuo, H. Wu, B. Shen
The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononu.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.14
- DOI:
- 10.4238/2015.July.28.14
Construction of a natural phage antibody library of human anaplastic thyroid carcinoma
Authors: J.M. Xi, H. Pang, X.L. Hu and Z.J. Wang
The objective of this study was to identify and construct a human natural phage single-chain antibody (scFv) library of human anaplastic thyroid carcinoma (ATC) using phage display technology. Total RNA was extracted from lymphatic tissue near an ATC and used to amplify variable heavy chain (VH) and variable light chain (VL) fragments with added linker se.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.6
- DOI:
- 10.4238/2015.July.28.6
Non-parental banding patterns in recombinant inbred line population of maize with SSR markers
Authors: R.V. Ramekar, K.J. Sa, S.Y. Woo and J.K. Lee
We observed 3 types of non-parental banding patterns using simple-sequence repeat primers in a recombinant inbred line maize population developed from 2 inbred lines, Mo17 and KW7. We observed alleles that were not present in either of the parents, known as non-parental alleles. Although non-parental alleles are a consequence of genetic variation, they ar.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.9
- DOI:
- 10.4238/2015.July.28.9
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women
Authors: L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.15
- DOI:
- 10.4238/2015.July.28.15
Isolation and characterization of microsatellite markers of sea cucumber Stichopus horrens
Authors: Z.B. Li, G. Dai, J.B. Shangguan, Y.F. Ning, Y.Y. Li, R.B. Chen, Y. Yuan and Y.S. Huang
Curry fish (Stichopus horrens) is a tropical holothurian species and is widely distributed in the India-West Pacific. In the present study, 9 polymorphic microsatellite loci were isolated and characterized for S. horrens. These loci were tested in 30 individuals from Hainan Island in China. The number of alleles ranged from 2 to 5. The polymorphism inform.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.18
- DOI:
- 10.4238/2015.July.28.18
Molecular cloning and bioinformatic analysis of the Streptococcus agalactiae neuA gene isolated from tilapia
Authors: E.L. Wang, K.Y. Wang, D.F. Chen, Y. Geng, L.Y. Huang, J. Wangand Y. He
Cytidine monophosphate (CMP) N-acetylneuraminic acid (NeuNAc) synthetase, which is encoded by the neuA gene, can catalyze the activation of sialic acid with CMP, and plays an important role in Streptococcus agalactiae infection pathogenesis. To study the structure and function of the S. agalactiae neuA gene, we isolated it from diseased tilapia, amplified.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.18
- DOI:
- 10.4238/2015.June.1.18