Medical Genetics

Preparation and biological activity of a paclitaxel-single-walled carbon nanotube complex

Authors: X.D. Fu, Y.Y. Zhang, X.J. Wang, J.X. Shou, Z.Z. Zhang andL.J. Song

Single-walled carbon nanotubes (SWCNTs) have unique transmembrane abilities. The huge superficial area and abundance of π electrons confer SWCNTs perfect absorptive capability toward proteins, nucleates, and many drugs. These characteristics make SWCNTs a new and efficient drug carrier. The purpose of this study was to disp.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.12.11

DOI:

http://dx.doi.org/10.4238/2014.March.12.11

Development of a cyclic voltammetry method for the detection of Clostridium novyi in black disease

Authors: L.L. Liu, D.N. Jiang, G.M. Xiang, C. Liu, J.C. Yu and X.Y. Pu

Black disease is an acute disease of sheep and cattle. The pathogen is the obligate anaerobe, Clostridium novyi. Due to difficulties of anaerobic culturing in the country or disaster sites, a simple, rapid, and sensitive method is required. In this study, an electrochemical method, the cyclic voltammetry method, basing on loop.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.January.14.9

DOI:

http://dx.doi.org/10.4238/2014.January.14.9

Mitogenome of Fejervarya multistriata: a novel gene arrangement and its evolutionary implications

Authors: Z.H. Huang and F.Y. Tu

In this study, we determined the complete nucleotide sequence of the mitochondrial (mt) DNA of the paddy frog Fejervarya multistriata. mtDNA is 17,750-bp long and contains 13 protein-coding regions, 2 ribosomal RNA, non-coding genes, and 23 tRNA because of the presence of an extra copy of tRNA-Met. The gene arrangements among two related species of Fejerv.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038302

DOI:

10.4238/gmr.15038302

Association between the -174 G/C polymorphism of the interleukin-6 gene and myocardial infarction risk: a meta-analysis

Authors: J. Zhou, J. Feng and X. Li

Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 gene (IL6) and myocardial infarction (MI) risk. However, the results from the published studies are inconclusive. The aim of this meta-analysis was to determine whether the IL6 -174 G/C polymorphism is associated with MI risk. A meta-analysis based on ni.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038358

DOI:

10.4238/gmr.15038358

Association between expression of DNA mismatch repair genes and clinical features and prognosis of patients with radical resection of colon cancer

Authors: J.B. Wang, D.L. Ma, J.Y. Li, Q.D. Sun and Y.E. Liu

The aim of this study was to investigate the clinical significance of the expression of DNA mismatch repair (MMR) genes in patients subjected to radical surgical removal of colon cancer, as well as their correlation with disease prognosis. Ninety stage II and III colon cancer patients who received laparoscopic radical resection of colon cancer at our hosp.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038388

DOI:

10.4238/gmr.15038388

Assessment of genetic relationship among Rhododendron cultivars using amplified fragment length polymorphism and inter-simple sequence repeat markers

Authors: J.J. Xu, B. Zhao, H.F. Shen, W.M. Huang and L.X. Yuan

Genetic relationships of 17 Rhododendron cultivars, China, were assessed using inter-simple sequence repeat (ISSR) and amplified fragment length polymorphism (AFLP) markers. A total of 133 bands were obtained using nine selected ISSR primers, 129 (96.99%) of which were polymorphic; 267 bands were amplified by four AFLP primer pairs, 251 (94.01%) of which .. Read More»

Genet. Mol. Res. 15(3):

gmr.15038467

DOI:

10.4238/gmr.15038467

Dephosphorylation of NSSR1 regulates alternative splicing of the GluR-B minigene

Authors: W. Zhang, L.L. Li, X.H. Chen and Z.Y. Peng

Neural salient serine/arginine-rich protein 1 (NSSR1, alternatively SRp38) is an important splicing factor that can repress pre-mRNA alternative splicing in cells during heat shock and mitosis. We show here that NSSR1 protein is dephosphorylated when cells are heat shocked or incubated with kinase inhibitor K252a. Both heat sh.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.3

DOI:

http://dx.doi.org/10.4238/2014.March.17.3

Balanced reciprocal translocation at amniocentesis: cytogenetic detection and implications for genetic counseling

Authors: H.G. Zhang, X.Y. Zhang, H.Y. Zhang, T. Tian, S.B. Xu and R.Z. Liu

Balanced translocation is a common structural chromosomal rearrangement in humans. Carriers can be phenotypically normal but have an increased risk of pregnancy loss, fetal death, and the transmission of chromosomal abnormalities to their offspring. Existing prenatal screening technologies and diagnostic procedures fail to detect balanced translocation, s.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038556

DOI:

10.4238/gmr.15038556

Genetic and epigenetic diversity and structure of Phragmites australis from local habitats of the Songnen Prairie using amplified fragment length polymorphism markers

Authors: T. Qiu, L.L. Jiang and Y.F. Yang

The genetic and epigenetic diversity and structure of naturally occurring Phragmites australis populations occupying two different habitats on a small spatial scale in the Songnen Prairie in northeastern China were investigated by assessing amplified fragment length polymorphisms (AFLPs) and methylation-sensitive amplified polymorphisms (MSAPs) through fl.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038585

DOI:

10.4238/gmr.15038585

Boning up on mutations: assessing the significance of candidate disease-causing DNA sequence variation

Authors: R. Dalgleish

Genet. Mol. Res. 10(3):

vol10-3gmr1353

DOI:

10.4238/vol10-3gmr1353