Medical Genetics
An interspecific QTL study of Drosophila wing size and shape variation to investigate the genetic basis of morphological differences
Authors: B.P. Matta and B.C. Bitner-Math�©
The Drosophila wing has been used as a model in studies of morphogenesis and evolution; the use of such models can contribute to our understanding of mechanisms that promote morphological divergence among populations and species. We mapped quantitative trait loci (QTL) affecting wing size and shape traits using highly inbred i.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr929
- DOI:
- 10.4238/vol9-4gmr929
Differential diagnosis of active hypodermal and hematopoietic necrosis virus based on gene choice and reverse transcription coupled with PCR
Authors: M.A. Teixeira, J.E.F. Cruz, P.R.N. Vieira, I.R.C. Branco, F.H.F. Costa and G. R�¡dis-Baptista
The Pacific whiteleg shrimp Litopenaeus vannamei (Penaeidae) is one of the most important cultivated species in world aquaculture. In Brazil, the northeastern states are home to the main shrimp producers. As shrimp aquaculture has expanded and intensified, diseases have progressively become one of the most serious threats to t.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr917
- DOI:
- 10.4238/vol9-4gmr917
The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats
Authors: A.S. Yar, S. Menevse and E. Alp
Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.7
- DOI:
- 10.4238/2011.November.29.7
Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage
Authors: W.W. Zhu, X.L. Ma, A.L. Guo, H.Y. Zhao and H.H. Luo
The hypoxic-ischemic encephalopathy caused by peripartum asphyxia is a serious disease in newborn infants, and effective therapies need to be developed to reduce injury-related disorders. We evaluated the effects of NEP1-40 and fasudil on Nogo-A expression in neonatal hypoxic-ischemic brain damage (HIBD) rats. Seven-day-old Wi.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.9
- DOI:
- 10.4238/2011.November.29.9
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China
Authors: H.L. Wei, J.R. Pei, C.X. Jiang, L.W. Zhou, T. Lan, M. Liu and T. Wang
Keshan disease (KD) is an endemic cardiomyopathy associated with selenium deficiency. Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism,.. Read More»
- Genet. Mol. Res. 10(4):
Carnitine and carnitine orotate affect the expression of the prolactin-releasing peptide gene
Authors: H.S. Zhu, Y.Y. Wang, M.W. Lin, J.X. Du, L.Q. Hang, Y. Chen and L.F. Wang
Carnitine is involved in fatty acid metabolism in mammals and is widely used as a nutritional supplement; carnitine orotate is a more absorbable form of carnitine. We investigated the effects of carnitine and carnitine orotate on mouse prolactin-releasing peptide (PrRP) mRNA expression. Twenty-four female mice were randomly di.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.6.1
- DOI:
- 10.4238/2011.December.6.1
Application of the Sleeping Beauty system in Saanen goat fibroblast cells for establishing persistent transgene expression
Authors: B.C. Jiang, H.A. Kaleri, H.X. Zhang, J. Chen and H.L. Liu
The Sleeping Beauty (SB) transposon system is a promising new method for establishing persistent transgene expression in vivo. We applied the SB system for enhancing transgenesis in Saanen dairy goat fibroblast cells. We constructed a pKT2/CMV-EGFP-IRES-PURO vector and investigated the influence of transposon and transposase v.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.25.4
- DOI:
- 10.4238/2011.October.25.4
Association between interleukin 21 and Graves� disease
Authors: H.Y. Jia, Z.G. Zhang, X.J. Gu, T. Guo, B. Cui, G. Ning and Y.J. Zhao
Graves’ disease (GD) is an organ-specific autoimmune thyroid disease; 25-50% of GD patients will develop Graves’ ophthalmopathy (GO). The etiology of GD and GO may be multifactorial, but the immune response plays a central role. Many studies have reported that IL-21 has crucial roles in autoimmune diseases. We exam.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.6
- DOI:
- 10.4238/2011.October.31.6
Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis
Authors: H. Yuan, Y.M. Niu, R.X. Wang, H.Z. Li and N. Chen
Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and n.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.22.6
- DOI:
- 10.4238/2011.November.22.6
A new approach for cloning hLIF cDNA from genomic DNA isolated from the oral mucous membrane
Authors: Y.H. Cui, G.Q. Zhu, Q.J. Chen, Y.F. Wang, M.M. Yang, Y.X. Song, J.G. Wang and B.Y. Cao
Complementary DNA (cDNA) is valuable for investigating protein structure and function in the study of life science, but it is difficult to obtain by traditional reverse transcription. We employed a novel strategy to clone human leukemia inhibitory factor (hLIF) gene cDNA from genomic DNA, which was directly isolated from the m.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.25.2
- DOI:
- 10.4238/2011.November.25.2