Medical Genetics
Expression and role of cyclophilin B in stomach cancer
Authors: D.Q. Meng, P.L. Li and M. Xie
We elucidated the expression of ciclosporin protein B (cyclophilin B) in stomach cancer tissue and the correlation between cyclophilin B and clinicopathological parameters, and determined the effect of cyclophilin B on growth and proliferation of stomach cancer cells. Pathological sections of stomach cancer and paracancerous tissue were collected for dete.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.5
- DOI:
- 10.4238/2015.May.22.5
Mechanism of SEMA3B gene silencing and clinical significance in glioma
Authors: C.H. Pang, W. Du, J. Long and L.J. Song
The aim of the current study was to explore mechanisms of SEMA3B gene expression and its clinical significance in glioma, and provide a theoretical foundation for investigating individualized treatment in glioma. Paraffin-embedded tissues from 43 patients with a confirmed clinical diagnosis of glioma following neurosurgery at the First Affiliated Hospital.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017664
- DOI:
- 10.4238/gmr.15017664
Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens
Authors: P.A. Ko��ar, M. Ko�§er, D.A. ��elik and N. ��z�§elik
The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patient.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017699
- DOI:
- 10.4238/gmr.15017699
Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer
Authors: Y. Dong, J.W. Liu, Y.J. Gao, T. Zhou and Y.M. Chen
We examined the relationships between singlenucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therap.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.8
- DOI:
- 10.4238/2015.May.22.8
Effects of docetaxel plus three-dimensional conformal radiation therapy on microvessel density and apoptosis expression in local advanced squamous non-small-cell lung cancer
Authors: X.J. Zhai, H.R. Cheng, H.L. Long, W.K. Mao, L. Cao, B.R. Xiao and R.Q. Li
We examined the effects of weekly single-agent docetaxel plus three-dimensional conformal radiation therapy (3D-CRT) on apoptotic index (AI) and microvessel density (MVD) in local advanced non-small-cell lung squamous cancer patients and analyzed the correlation of MVD, AI, and 50% tumor shrinkage time (T0.5) The molecular mechanism of docetaxel radiosens.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.9
- DOI:
- 10.4238/2015.May.22.9
Immunohistochemical detection and clinicopathological significance of JARID1B/ KDM5B and P16 expression in invasive ductal carcinoma of the breast
Authors: L.H. Zhao and H.G. Liu
The aims of this study were to investigate the expression of the H3K4 demethylase, jumonji AT-rich interactive domain 1B (JARID1B/KDM5B) and of p16 (multiple tumor suppressor gene MTS1) in breast cancer tissue and determine its clinicopathological significance. JARID1B/KDM5B and P16 protein expression in 176 resected breast cancer specimens and adjacent n.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.11
- DOI:
- 10.4238/2015.May.22.11
Effects of Astragaloside IV on diabetic nephropathy in rats
Authors: W.-S. Lu, S. Li, W.-W. Guo, L.-L. Chen and Y.-S. Li
The aims of this study were to explore the effects of Astragaloside IV on diabetic nephropathy (DN) rats. A total of 38 male Sprague-Dawley (SD) rats were divided into three groups: 10 in the normal (control) group, 14 in the DN model group, and 14 in the AS-IV group. Treatment began one week after the streptozotocin DN model was successfully established... Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.12
- DOI:
- 10.4238/2015.May.22.12
Selection of DNA barcoding loci for Nepeta deflersiana Schweinf. ex Hedge from chloroplast and nuclear DNA genomes
Authors: F. Al-Qurainy, S. Khan, M. Nadeem, M. Tarroum and A.R.Z. Gaafar
Molecular markers, mainly DNA-based are potential tools for DNA barcoding and phylogenetic study. The plant species belonging to the Nepeta genus have important medicinal value because of the presence of nepetalactones, and they have been used to treat human diseases. We amplified nuclear and chloroplast gene loci to develop a.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.21.3
- DOI:
- 10.4238/2014.February.21.3
Lack of association between a common polymorphism of the endothelial lipasegene and early-onset coronary artery disease in a Chinese Han population
Authors: G.J. Cai, G.P. He, Z.Y. Huang, and C.P. Qi
A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.7
- DOI:
- 10.4238/2014.February.20.7
Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro
Authors: Y.-B. Deng, H.-J. Qin, Y.-H. Luo, Z.-R. Liang and J.-J. Zou
The aim of this study was to investigate the effects of inhibition of the hepatitis B virus (HBV) S gene by polypurine region locked nucleic acid on viral replication in cells. We designed and synthesized a locked nucleic acid, phosphorothioate oligonucleotides, unmodified oligonucleotides, and unrelated control sequence for the hepatitis B virus S gene p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.14
- DOI:
- 10.4238/2015.May.22.14