Medical Genetics
Huwe1 as a therapeutic target for neural injury
Authors: J. Zhou, Q. Liu M. Mao and Y. Tong
The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer’s disease, and Parki.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.18
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.18
Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients
Authors: L. Wang, L.H. Liu, W.H. Tong, M.X. Wang and S.C. Lu
We examined the influence of the cytochrome P450 3A5 (CYP3A5) genes in both donors and recipients on the concentration-dosage ratio (C/D) of tacrolimus in Chinese liver transplant patients. Fifty-one adult liver transplant patients who received tacrolimus were included in this study. The CYP3A5 polymorphism i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.3
- DOI:
- 10.4238/2015.November.25.3
Association between the EGF rs4444903 polymorphism and liver cancer susceptibility: a meta-analysis and meta-regression
Authors: Y.L. Li1, Z. Tian2, L. Zhao2 and C.L. Zhang2
Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual’s susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver .. Read More»
- Genet. Mol. Res. 13(4):
Relationship between perioperative cardiovascular risk factors and bone marrow cells from patients undergoing coronary artery bypass grafting surgery
Authors: L. Zhang, R. Wang, C.-S. Xiao, Y. Wu and C.-Q. Gao
Cell therapy through the implantation of autologous bone marrow cells has long been used in clinical trials for the treatment of ischemic heart diseases. However, as the outcomes of cell implantation vary among patients, risk factors that might influence the level and function of bone marrow progenitor cells should be determin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.11
- DOI:
- 10.4238/2015.November.25.11
Investigation of AZF microdeletions in patients with Klinefelter syndrome
Authors: L.X. Li, H.Y. Dai, X.P. Ding, Y.P. Zhang, X.H. Zhang, H.Y. Ren and Z.Y. Chen
We investigated azoospermia region microdeletions in male infertility patients with Klinefelter syndrome (KFS), as well as the association between azoospermia symptoms in patients with KFS and Y chromosome microdeletion polymorphisms. A total of 111 cases with male infertility confirmed to have KFS (47, XXY) and 94 fertile men.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.2
- DOI:
- 10.4238/2015.November.25.2
Association of adiponectin gene polymorphisms with hypertensive disorder complicating pregnancy and disorders of lipid metabolism
Authors: Y. Wang, R.X. Liu and H. Liu
The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in APM1 contribute to disorders of lipid metabolism in hypertensive disorder complicating pregnancy (HDCP). The study included 178 pregnant women with HDCP and 243 healthy pregnant controls. Using PCR-restriction fragment length poly.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.9
- DOI:
- 10.4238/2015.November.25.9
Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis
Authors: X.-H. Luo, G.-R. Li and H.-Y. Li
Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.1
- DOI:
- 10.4238/2015.November.25.1
Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children
Authors: J.S. Xi, C.L. Nie, J. Wang, Y. Ma and A.H. Ma
Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.13
- DOI:
- 10.4238/2015.November.25.13
Identification of differently expressed genes in leukemia using multiple microarray datasets
Authors: Z.Y. Zhang, R.Q. Xu, T.J. Guo, M. Zhang, D.X. Li and X.Y. Lu
The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto E.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.9
- DOI:
- 10.4238/2014.December.12.9
New polymorphic microsatellite markers for the Korean manila clam (Ruditapes philippinarum) and their application to wild populations
Authors: E.M. Kim1, H.S. An1, J.H. Kang1, C.M. An1, C.M. Dong1, Y.K. Hong2 and J.Y. Park1
Manila clam (Ruditapes philippinarum) is a valuable and intensively exploited shellfish species in Korea. Despite its importance, information on its genetic background is scarce. For the genetic characterization of R. philippinarum, expressed sequence tag-derived microsatellite markers were developed using next-generation sequencing. A total of 5879 tande.. Read More»
- Genet. Mol. Res. 13(4):