Human Genetics
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population
Authors: Q. Zhong, R.R. Wu and Z.M. Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038682
- DOI:
- 10.4238/gmr.15038682
Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population
Authors: H.C. Liu, J. Zhang, S. Wong, D. Han, H.S. Zhao and H.L. Feng
Tooth agenesis is one of the most common anomalies of human dentition. Recent genetic studies have provided information regarding a number of genes related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.3.4
- DOI:
- 10.4238/2014.April.3.4
Clinical significance of combined liver function and high-sensitivity C-reactive protein measurement in children with hand-foot-mouth disease
Authors: F.X. Han, J.H. Gao and J.H. Gai
Hand-foot-mouth disease (HFMD) is a common pediatric disease responsible for the development of rashes or herpes on the hand, foot, and mouth. Severe complications of HFMD include myocarditis, pulmonary edema, aseptic meningoencephalitis, and even death. Therefore, early diagnosis of HFMD is of particular importance. In this study, we determined the clini.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038744
- DOI:
- 10.4238/gmr.15038744
Marsdenia tenacissima extract sensitizes MG63 cells to doxorubicin-induced apoptosis
Authors: T. Huang, W.H. Gong, C.P. Zou, X.C. Li, G.J. Jiang, X.H. Liand H. Qian
Marsdenia tenacissima extract (MTE) is a new plate-derived biotechnology product that is frequently used, but occasionally reported, in the field of chemotherapy. In this study, we assessed the antitumor activity and related mechanisms of MTE by various biotechnological methods. The survival rates of MG63 osteosarcoma cells tr.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.21.3
- DOI:
- http://dx.doi.org/10.4238/2014.January.21.3
Clinical value of detection of immune index and inflammatory reaction changes in patients with autoimmune disease
Authors: X.J. Zhang, H.Y. Zhou and Y. Li
Previous studies have shown a close correlation between the generation of B cell autoantibodies and imbalances in T lymphocyte subpopulations and the occurrence of disease. In this study, we have analyzed the effects of abnormal expression of CD4+CD25+-regulatory T cells, T lymphocyte subpopulations, immunoglobulins, complement factors, inflammatory facto.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038745
- DOI:
- 10.4238/gmr.15038745
Establishment of cytochrome P450 3A4 and glutathione S-transferase A1-transfected human hepatoma cell line and functional analysis
Authors: B.X. Chang, S.L. You, H.L. Liu, P.Y. Mao and S.J. Xin
This study aimed to enhance the drug metabolism function of the human hepatoma cell line C3A and to explore the related significance for patients with severe liver disease. The important liver phase I and phase II drug metabolism enzymes, cytochrome P450 3A4 (CYP 3A4) and glutathione S-transferase A1 (GST A1), were constructed.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.11
- DOI:
- 10.4238/2014.April.14.11
Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
Authors: M.Y. Li, M. Zhu, F. Feng, F.Y. Cai, K.C. Fan, H. Jiang, Z.Q. Wang and E.Q. Linghu
The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and meta.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.13
- DOI:
- 10.4238/2014.April.14.13
Serum thyroid hormone reference intervals in the apparently healthy individuals of Zhengzhou area of China
Authors: P. Wang, Y.J. Gao, J. Cheng, G.L. Kong, Y. Wang, X.Y. Wu, Z.G. Zhao and H.J. Yuan
This study aimed to establish reference intervals for serum thyroid hormones [serum thyroid-stimulating hormone (TSH), triiodothyronine (TT3), thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4)] in apparently healthy individuals living in Zhengzhou. According to the requirement for laboratory support for th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.15
- DOI:
- 10.4238/2014.April.14.15
Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients
Authors: F. Attaran-Bandarabadi, A.A. Ziaee, M. Yazdanbod, M. Shahpanah, A. Setayeshgar and M. Nassiri
There is a high incidence of esophageal squamous cell carcinoma (ESCC) in Iran. Non-functionality of some tumor suppressor genes has been reported in esophageal cancer. Loss of heterozygosity on chromosome 5 has also been reported in esophageal carcinomas. We assessed loss of heterozygosity along a region of the long arm of ch.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.5.2
- DOI:
- 10.4238/2011.October.5.2
Application of ultrasound technology in the study of ischemic postconditioning to protect testes from ischemia-reperfusion injury
Authors: E.S. Xue, Q.Q. Chen, Y. Wang, Y. Zhang, S. Chen and R.X. Liang
This study was designed to investigate the application of ultrasound technology in the study of ischemic postconditioning to protect testes from ischemia-reperfusion injury. Seventy-two big white rabbits were divided into mild ischemic groups (Group A: A0, A1, A2, A3), moderate ischemic groups (Group B: B0, B1, B2, B3) under u.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.30.11
- DOI:
- 10.4238/2014.April.30.11