Human Genetics
Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women
Authors: J.J. Zhao, D.H. Feng, L. Cheng, T. Lu and L. Wang
The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.16
- DOI:
- 10.4238/2014.March.24.16
Repair of cartilage defects in BMSCs via CDMP1 gene transfection
Authors: G. Wu, Y. Cui, Y.T. Wang, M. Yao, J. Hu, J.X. Li, Y. Wang andB. Zhang
This study aimed at investigating the ability of cartilage-derived morphogenetic protein 1 (CDMP1) gene-transfected bone marrow mesenchymal stem cells (BMSCs) loaded on the poly(lactic-co-glycolic acid) (PLGA) scaffold for the repair of laryngeal cartilage defects and make a preliminary assessment of its repair effect. The mRN.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.14
- DOI:
- 10.4238/2014.January.17.14
Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer
Authors: Z.Q. Wang,X.L. Sun,H.L. Su,X.F. Liu,Y.J. Xuan,S.Q. Yu
We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.5
- DOI:
- 10.4238/2015.December.1.5
Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians
Authors: J.W. Fu, X.Q. Chu
The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.11
- DOI:
- 10.4238/2015.December.1.11
Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population
Authors: A. Sandoval-Carrillo, M. Aguilar-Duran, F. V�¡zquez-Alaniz,F.X. Castellanos-Ju�¡rez, M. Barraza-Salas, E. Sierra-Campos, A. T�©llez-Valencia O. La Llave-Le�³n and J.M. Salas-Pacheco
Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutat.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.17.3
- DOI:
- http://dx.doi.org/10.4238/2014.January.17.3
Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis
Authors: M.J. Ma, H.C. Liu, X.Q. Qu, J.L. Wang
Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.17
- DOI:
- 10.4238/2015.December.1.17
Effects of polymorphisms in the XRCC1, XRCC3, and XPG genes on clinical outcomes of platinum-based chemotherapy for treatment of non-small cell lung cancer
Authors: Z.Y. Jin, X.T. Zhao, L.N. Zhang, Y. Wang, W.T. Yue and S.F. Xu
This study aimed to investigate the effects of single-nucleotide polymorphisms (SNPs) XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPG His104Asp, and XPG His46His in genes involved in the DNA-repair pathway on the outcomes of platinum-based chemothera.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.31.13
- DOI:
- 10.4238/2014.March.31.13
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
Authors: X.S. Gu, Z.B. Wang, Z. Ye, J.P. Lei, L. Li, D.F. Su and X. Zheng
Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator (SIRT1), on cardiac function and AMPK expression in heart failure. Adult .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.17.17
- DOI:
- http://dx.doi.org/10.4238/2014.January.17.17
Association of a transforming growth factor-�²1 polymorphism with acute coronary syndrome in a Chinese Han population
Authors: Y.N. Yang, B. Zhao, X.M. Li, X. Xie, F. Liu and B.D. Chen
Acute coronary syndrome (ACS) is a complex multifactorial and polygenic disorder that is thought to result from the interaction between an individual’s genetic makeup and various environmental factors. The aim of this study was to investigate the association of a transforming growth factor-β1 (TGF-β1) polymorph.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.3.2
- DOI:
- 10.4238/2014.April.3.2
Development of polymorphic microsatellite markers and the population genetic structure of the half-fin anchovy, Setipinna taty
Authors: Y.N. Sun, Y. Qin, Z.H. Zhu and D.Q. Sun
Microsatellite markers for the half-fin anchovy Setipinna taty were developed from the enriched (CA)15 genomic library, and they were used for the population genetic studies of the half-fin anchovy from Chinese coastal areas. Samples were collected from five localities of the East China Sea and the Yellow S.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.3.1
- DOI:
- 10.4238/2014.April.3.1