Human Genetics
Inhibition effect of silver nanoparticles on herpes simplex virus 2
Authors: R.L. Hu, S.R. Li, F.J. Kong, R.J. Hou, X.L. Guan and F. Guo
The herpes simplex virus 2 (HSV-2) is one of the most important sexually transmitted pathogens, and can facilitate the spread of human immunodeficiency virus. The currently available antiviral drugs have certain limitations. Nanosilver has received increasing attention recently with respect to its antibacterial and antiviral p.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.2
- DOI:
- 10.4238/2014.March.19.2
Effects of mutant TDP-43 on the Nrf2/ARE pathway and protein expression of MafK and JDP2 in NSC-34 cells
Authors: Y.P. Tian, F.Y. Che, Q.P. Su, Y.C. Lu, C.P. You, L.M. Huang,S.G. Wang, L. Wang and J.X. Yu
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons and lacks an effective treatment. The disease pathogenesis has not been clarified at present. Pathological transactive response DNA-binding protein 43 (TDP-43) plays an important role in the pathogenesis of ALS. Nuclear translocation .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029638
- DOI:
- 10.4238/gmr16029638
Effects of the ginkgo biloba extract on the superoxide dismutase activity and apoptosis of endothelial progenitor cells from diabetic peripheral blood
Authors: M. Zhao, X.-X. Wang and W.-H. Wan
Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic per.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.1
- DOI:
- 10.4238/2014.January.14.1
NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the ris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.3
- DOI:
- 10.4238/2014.March.19.3
Construction of a tissue engineered intervertebral disc with high biological activity using an allogeneic intervertebral disc supplemented with transfected nucleus pulposus cells expressing exogenous dopamine beta-hydroxylase
Authors: M. Bai, Y.H. Wang, H.P. Yin and S.W. Li
This study addressed the in vitro construction and biological activity of tissue engineered intervertebral discs with exogenous human dopamine beta-hydroxylase (DBH) nucleus pulposus cells. pSNAV2.0-DBH expression plasmids were utilized to enhance the survival rates of intervertebral disc tissue cells. Various concentrations of transfected nucleus pulposu.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.6
Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy
Authors: Zhang, W. Ma, Y. Li, J. Wu and G.Y. Shi
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on tre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.2
- DOI:
- 10.4238/2014.January.14.2
A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia
Authors: T.D. Zhong, Q. Liu, J.N. Zhao, H.W. Wang and A. Konstantatos
This study aimed to evaluate whether combined oral oxycodone hydrochloride-controlled release tablets plus paracetamol and tramadol hydrochloride tablets are more effective than epidural analgesia for postoperative pain control and side effects after cesarean section. We randomly enrolled 60 patients scheduled for cesarean sec.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.4
- DOI:
- 10.4238/2014.March.19.4
Survey of attitude and knowledge of reproductive health among middle school students in Luoyang, China
Authors: P. Wang, Y.J. Zhang, X.J. Pan, X.Y. Xia and S.Y. Lv
The aim of this study was to assess the knowledge and attitude of AIDS and sexual behavior of middle school students. Structural questionnaires were designed to interview 1980 junior and senior middle school students about their basic knowledge, attitude, and behavior with respect to AIDS and sexual behavior. Students were rec.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.17
- DOI:
- 10.4238/2014.March.24.17
Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility
Authors: S.-S. Li, J. Li, Z. Xiao, A.-G. Ren and L. Jin
The aim of this study was to explore the relationship between 2 genetic polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR), C677T and A1298C, and determine the long-term reproductive outcome in infertile men. This was a prospective study conducted in an andrology clinic. Men with a 1-year history of.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.26
- DOI:
- 10.4238/2014.March.24.26
Efficacy and safety of nucleoside analogues in preventing vertical transmission of the hepatitis B virus from father to infant
Authors: L.-H. Cao,P.-L. Zhao,Z.-M. Liu,S.-C. Sun,D.-B. Xu,J.-D. Zhang,Z.-H. Shao
We examined the efficacy and safety of nucleoside analogues in preventing the vertical transmission of hepatitis B virus (HBV) from father to infant. We included 201 patients who visited the liver clinic of our hospital. The patients were positive for HBV surface antigen (HBsAg), HBeAg, anti-HBc, and HBV DNA; 189 patients (94%.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.4
- DOI:
- 10.4238/2015.December.1.4