Human Genetics
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation
Authors: Z.F. Xiong, J. Shi, Z.H. Fu, H.P. Wan and L.X. Tu
We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029181
- DOI:
- 10.4238/gmr16029181
�±-Thalassemia (3.7 kb deletion) in a population from the Brazilian Amazon region: Santar�©m, Par�¡ State
Authors: A.E.S. Souza, G.L. Cardoso, S.Y.L. Takanashi and J.F. Guerreiro
The ethnic composition of the Brazilian population favors high frequencies of the -α3.7 deletion, responsible for α-thalassemia, because this mutation is very common in African populations. In spite of its importance, this hemoglobinopathy has been poorly investigated in Brazil, especially at the molecular level. W.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr601
- DOI:
- 10.4238/vol8-2gmr601
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Authors: F.L. Campedelli, K.S.F. e Silva, D.A. Rodrigues, J.V.M. Martins, I.R. Costa, M.H. Lagares, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alteratio.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029550
- DOI:
- 10.4238/gmr16029550
Production of hGFAP-DsRed transgenic Guangxi Bama mini-pigs via somatic cell nuclear transfer
Authors: L.L. Hu, Y.Q. Lu, H.Y. Xu, X.G. Yang, S.S. Lu and K.H. Lu
The mini-pig is a useful animal model for human biomedical research due to its physiological similarity to humans and the ease of handling. In order to optimize the efficiency of production of transgenic Bama mini-pigs through somatic cell nuclear transfer (SCNT), we examined the effects of contact inhibition, roscovitine treatment, and serum starvation o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.19
- DOI:
- 10.4238/2015.December.8.19
Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis
Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang
Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.16
Isolation and characterization of polymorphic microsatellite markers in Bagarius yarrelli using RNA-Seq
Authors: M. Du, Y.H. Liu and B.Z. Niu
The yellow sisorid catfish (Bagarius yarrelli) is a vulnerable fish species. In this study, seven polymorphic microsatellite DNA markers for yellow sisorid catfish were described, using RNA-Seq methodology. In B. yarrelli (N = 44) from a Hekou wild population, allelic frequency, and observed and expected heterozygosities per locus varied from two to six, .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis
Authors: Y. Wang and T.T. Zeng
Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.11
- DOI:
- 10.4238/2014.February.21.11
Adaptive protection against damage of preconditioning human umbilical cord-derived mesenchymal stem cells with hydrogen peroxide
Authors: D. Li, Y. Xu, C.Y. Gao and Y.P. Zhai
Adaptive protection against damage to human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) was investigated by preconditioning with low-concentration hydrogen peroxide (H2O2) for a short-time period. Separation, culture, amplification, purification, and identification of immunophenotype and grow.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.9
- DOI:
- 10.4238/2014.February.21.9
Gene organization and characterization of the complete mitogenome of Hypsugo alaschanicus (Chiroptera: Vespertilionidae)
Authors: J.Y. Kim and Y.C. Park
We sequenced and characterized the complete mitogenome of Hypsugo alaschanicus (Vespertilionidae) to provide more data for comparative mitogenomics of the genus Hypsugo. The mitogenome of H. alaschanicus is a circular molecule of 17,300 bp, consisting of a control region and a typically conserved set of 37 vertebrate genes containing 13 protein-coding gen.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis
Authors: M. Zhai, Y. Wang and M.F. Jiang
Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.19
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.19