Human Genetics
Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology
Authors: E. Costa-Lira, A.H.V.L. Jacinto, L.M. Silva, P.F.R. Napole�£o,R.A.A. Barbosa-Filho, G.J.S. Cruz, S. Astolfi-Filho and C.M. Borborema-Santos
Sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. We investigated the prevalence of human papillomavirus (HPV), Chlamydia trachomatis (CT), and Trichomonas vaginalis (TV), and accessed the dive.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029626
- DOI:
- 10.4238/gmr16029626
Treatment of silicosis with hepatocyte growth factor-modified autologous bone marrow stromal cells: a non-randomized study with follow-up
Authors: W.W. Liu, H.X. Wang, W. Yu, X.Y. Bi, J.Y. Chen, L.Z. Chen, L. Ding, D.M. Han, Z.K. Guo and Y.X. Lei
Pulmonary silicosis is an irreversible and untreatable disease that is characterized by interstitial lesions and perpetual fibrosis in the lungs. This study was performed to determine whether mesenchymal stem cells (MSCs) and hepatocyte growth factor (HGF) could exhibit therapeutic effects on human silicosis. This non-randomized uncontrolled trial compris.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.7
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.7
Validation of a reaction volume reduction protocol for analysis of Y chromosome haplotypes targeting DNA databases
Authors: C.A. Souza, T.C. Oliveira, S. Crovella, S.M. Santos, K.C.N. Rab�ªlo, E.P. Soriano, M.V.D. Carvalho, A.F. Caldas Junior, G.G. Porto, R.I.C. Campello, A.A. Antunes, R.A. Queiroz and S.M. Souza
The use of Y chromosome haplotypes, important for the detection of sexual crimes in forensics, has gained prominence with the use of databases that incorporate these genetic profiles in their system. Here, we optimized and validated an amplification protocol for Y chromosome profile retrieval in reference samples using lesser .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029652
- DOI:
- 10.4238/gmr16029652
Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population
Authors: X.F. Li, Y.X. Chen, W.W. Ye, X.F. Tao, J.H. Zhu, S. Wu and L.Q. Lou
The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.7
- DOI:
- 10.4238/2014.January.10.7
Marker-assisted selection of Fusarium wilt-resistant and gynoecious melon (Cucumis melo L.)
Authors: P. Gao, S. Liu, Q.L. Zhu and F.S. Luan
In this study, molecular markers were designed based on the sex determination genes ACS7 (A) and WIP1 (G) and the domain in the Fusarium oxysporum-resistant gene Fom-2 (F) in order to achieve selection of F. oxysporum-resistant gynoecious melon plants. Markers of A and F are cleaved amplified polymorphic sequences that distinguish alleles according to res.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.16
- DOI:
- 10.4238/2015.December.8.16
Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients
Authors: R. Khalil, F. Al-Sheyab, E. Khamaiseh, M.A. Halaweh andH.A. Abder-Rahman
Maturity-onset diabetes of the young type 2 (MODY2) is a genetic form of diabetes mellitus caused by mutations in the glucokinase gene (GCK). We assessed the frequency of GCK gene mutations in Jordanian suspected MODY2 patients. We screened exons 7, 8 and 9, which are specific for pancreatic glucokinase, for mutations at posit.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr597
- DOI:
- 10.4238/vol8-2gmr597
Discovery and characterization of new microsatellite loci in Dipteryx alata Vogel (Fabaceae) using next-generation sequencing data
Authors: R.A. Guimar�£es, M.P.C. Telles, A.M. Antunes, K.M. Corr�ªa,C.V.G. Ribeiro, A.S.G. Coelho and T.N. Soares
The use of next-generation sequencing (NGS) technologies provides a great volume of genome sequence data even for non-model species. The development of microsatellite markers using these data is a relatively quick and easy process. Dipteryx alata Vogel (Fabaceae) is an arboreal species from the Cerrado biome and is considered .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029639
- DOI:
- 10.4238/gmr16029639
Haplotype distribution of five nuclear genes based on network genealogies and Bayesian inference indicates that Trypanosoma cruzi hybrid strains are polyphyletic
Authors: L. Tomazi, S.Y. Kawashita, P.M. Pereira, B. Zingales andM.R.S. Briones
Chagas disease is still a major public health problem in Latin America. Its causative agent, Trypanosoma cruzi, can be typed into three major groups, T. cruzi I, T. cruzi II and hybrids. These groups each have specific genetic characteristics and epidemiological distributions. Several highly virulent strains are found in the h.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr591
- DOI:
- 10.4238/vol8-2gmr591
Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity
Authors: M.Y. Zhang, F. Li and J.P. Wang
Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029210
- DOI:
- 10.4238/gmr16029210
Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese
Authors: L. Xiao, L.B. Gao and Q. Wei
The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.8
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.8