Human Genetics
Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients
Authors: Z.L. Zhang, X.M. Che, Z.H. Bai, W.J. Bu, L. Bai and H.H. Pei
Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blo.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.24.8
- DOI:
- 10.4238/2014.January.24.8
Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma
Authors: J. Liu, X.Y. Yang and W.J. Shi
Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC an.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.8
- DOI:
- 10.4238/2014.January.8.8
Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies
Authors: W.H. Ren, D.K. Jiang, Y. Pei, S.Q. Wang, X.M. Yang and L. Yu
Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) t.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.9
- DOI:
- 10.4238/2014.January.8.9
Correlation of E6 and E7 levels in high-risk HPV16 type cervical lesions with CCL20 and Langerhans cells
Authors: B. Jiang and M. Xue
The human papillomavirus (HPV)16 E6 and E7 correlation with chemokine ligand (CCL)20 expression and Langerhans cells (LCs) in cervical lesions was investigated. We enrolled 43 patients with surgically treated cervical lesions from the Department of Gynecology in our hospital, and 20 controls without cervical lesions. Subjects were divided by pathology: HP.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.8
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.8
BCR-ABL1 transcript types showed distinct laboratory characteristics in patients with chronic myeloid leukemia
Authors: A.P. Vasconcelos, I.F. Azevedo, F.C.B.C. Melo, W.B. Neves, A.C.A.C. Azevedo and R.A.M. Melo
In chronic myeloid leukemia (CML) two main types of messenger RNA (e14a2 and e13a2) can be produced by BCR-ABL1 gene rearrangement. Due to conflicting results, the clinical value of these transcripts remains controversial. The aim of this study was to identify associations of e14a2 and e13a2 transcripts with laboratory variabl.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029541
- DOI:
- 10.4238/gmr16029541
Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells
Authors: D.X. Li, J. Zhang, Y. Zhang, P.W. Zhao and L.M. Yang
Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-depe.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.17
Systematic review of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using free fetal DNA in maternal plasma
Authors: H. Yang, H.B. Xu, T.T. Liu and X.L. He
We evaluated the system accuracy of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using cell-free fetal DNA in maternal plasma. Previous studies were searched in the MEDLINE database using the following keywords: “prenatal” and “aneuploidy” and “noninvasive or non-invasive” and “maternal&.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.1
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.1
Expression profiles uncover the relevance between colony stimulating factor-mediated signaling pathways in liver cells and partial hepatectomy-induced hepatic regeneration
Authors: X.G. Chen and C.S. Xu
Colony stimulating factors (CSF) have been considered to modulate liver regeneration (LR) after partial hepatectomy (PH) at the tissue level. However, it remains unclear about precise mechanism of action of CSF in regeneration at the cellular level. Therefore, eight rat liver cell types were isolated by Percoll gradient centri.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.14.17
- DOI:
- 10.4238/2014.February.14.17
Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population
Authors: X.J. Zhu, W.Z. Li, H. Li, C.Q. Fu and J. Liu
The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured.. Read More»
- Genet. Mol. Res. 16(2):
A985G mutation incidence in the medium-chain acyl-CoA dehydrogenase (MCAD) gene in Brazil
Authors: A.C.S. Ferreira, M.P.A. Orlandi, V.C. Oliveira, F.S.V. Malta,F.A. Caxito, K.B. Gomes, E.R. Valadares and A.L.B. Godard
In view of the serious consequences of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and the absence of information about its incidence in the Brazilian population, we examined the frequency of the A985G mutation in the MCAD gene. A retrospective analysis was made of data on 1722 individuals (844 females) genotyped for.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr579
- DOI:
- 10.4238/vol8-2gmr579