Human Genetics
Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran
Authors: G. Bahari M. Hashemi M. Taheri M. Naderi A. Moazeni-Roodi H.R. Kouhpayeh E. Eskandari-Nasab
Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.24.8
- DOI:
- 10.4238/2013.January.24.8
Lack of association between TYK2 and STAT3 genes and Crohn�s disease in the Malaysian population
Authors: L.H. Lian T.P. Lau V.L. Lee W.S. Lee I. Hilmi K.L. Goh K.H. Chua
This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn’s disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods were employed for genotyping, followed by statistical an.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.24.9
- DOI:
- 10.4238/2013.January.24.9
Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis
Authors: F.J. You and D.M. Shen
Insertion/deletion (I/D) polymorphisms of the gene encoding angiotensin converting enzyme (ACE) are a controversial risk factor for heart diseases (HDs). ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases. However, some studies have presented conflicting results. In this study, we aim to explore the association be.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017194
- DOI:
- 10.4238/gmr.15017194
Abnormal metabolites related to bone marrow failure in aplastic anemia patients
Authors: P. Zhong, J. Zhang and X. Cui
Metabolomics is the identification and quantitation of small molecules that are involved in metabolic reactions. Liquid chromatography-mass spectrometry (LC-MS) has enjoyed growing popularity as the platform for metabolomic studies due to high throughput, soft ionization, and good coverage of metabolites. Serum metabolites of aplastic anemia (AA) patients.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.33
- DOI:
- 10.4238/2015.October.28.33
Karyotype studies on Lycoris radiata populations from China
Authors: Y.X. Liu1, Y.H. Zheng1,2, T. Xia1 and J. Zhou1
Lycoris radiata is an important medicinal and ornamental plant of China. In the present study, somatic chromosome counts and karyotype analyses, which are important aspects of plant phylogeny and evolution, were performed in 466 individuals from 25 L. radiata populations by root tip squash method. Chromosome counts revealed that 10 populations were diploi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017357
- DOI:
- 10.4238/gmr.15017357
Structure characterization of human cytomegalovirus UL131A, UL130 and UL128 genes in clinical strains in China
Authors: Z.-R. Sun, Y.-H. Ji, Q. Ruan, R. He, Y.-P. Ma, Y. Qi, Z.-Q. Mao,Y.-J. Huang
Human cytomegalovirus (HCMV) genetic determinants of endothelial cell tropism, leukocytes and dendritic cells have been identified in the genes UL131A, UL130, and UL128. We examined the structure of these three genes in HCMV. Eighteen low-passage clinical isolates and five non-passage strains from congenitally HCMV-infected in.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr654
- DOI:
- 10.4238/vol8-3gmr654
Genetic variability and heterogeneity of Venezuelan equine encephalitis virus vector Ochlerotatus taeniorhynchus (Diptera: Culicidae) populations of the Colombian Atlantic coast, based on microsatellite loci
Authors: F. Bello and V. Becerra
In Colombia, the mosquito Ochlerotatus taeniorhynchus has been identified as an efficient vector of the epidemic-epizootic Venezuelan equine encephalitis virus. We evaluated the genetic variability and heterogeneity of this mosquito in Colombian populations using eight microsatellite DNA loci. Two hundred and te.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr652
- DOI:
- 10.4238/vol8-3gmr652
Relationship between CYP17 gene polymorphisms and risk of prostate cancer
Authors: J. Song, Z.-H. Tao, X.-Y. Liu, S. Gong and L. Gan
Cytochrome P450 17a-hydroxylase (CYP17) plays a critical role in androgen biosynthesis. Polymorphisms of the CYP17 promoter have been proposed as risk factors for prostate cancer; however, some studies have produced inconclusive or controversial results. We investigated the relationship between polymorphisms of the CYP17 gene and the risk of prostate canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017866
- DOI:
- 10.4238/gmr.15017866
POPREP: a generic report for population management
Authors: E. Groeneveld, B.v.d. Westhuizen, A. Maiwashe, F. Voordewind and J.B.S. Ferraz
Genetic variation provides a basis upon which populations can be genetically improved. Management of animal genetic resources in order to minimize loss of genetic diversity both within and across breeds has recently received attention at different levels, e.g., breed, national and international levels. A major need for sustain.. Read More»
- Genet. Mol. Res. 8(3):
Analysis of protein expression and a new prokaryotic expression system for goat (Capra hircus) spermadhesin Bdh-2 cDNA
Authors: J.B. Cajazeiras, L.M. Melo, E.S. Albuquerque, G. R�¡dis-Baptista, B.S. Cavada and V.J.F. Freitas
Low purification efficiency and incomplete characterization of male goat (buck) spermadhesins (Bdhs) prompted us to develop an effective system to produce recombinant Bdhs (rBdhs). Bdh-2 cDNA was inserted into a prokaryotic expression plasmid, pTrcHis TOPO. The pTrcHis-Bdh-2 system was constructed to produce a His6 fusion.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr639
- DOI:
- 10.4238/vol8-3gmr639