Human Genetics
Effect of IL-1�², IL-8, and IL-10 polymorphisms on the development of myocardial infarction
Authors: S. Wang, Y.X. Dai, L.L. Chen, T. Jiang, M.Q. Zheng, C.G. Li, Y.P. Chen, W.H. Lin, J.F. Zhang and J. Jiang
Myocardial infarction (MI) is currently a leading cause of death worldwide, and is caused by various environmental and genetic factors. We therefore conducted a case-control study to investigate the association between polymorphisms in interleukins IL-1β, IL-8, and IL-10 and MI risk. This study recruited 260 MI patients a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.14
- DOI:
- 10.4238/2015.October.5.14
Integrity of prokaryotic mRNA isolated from complex samples for in vivo bacterial transcriptome analysis
Authors: A.B. Ferreira-Machado, M.C.R. Freitas, G.R.Q. Saji, A.B. Rezende, P.E. Almeida, D.E. Cesar, J.A. Resende1, M.F. Nic�³las2, V.L. Silva and C.G. Diniz
Even though several in vitro studies have focused on bacterial biology, the extent of such knowledge is not complete when considering an actual infection. As culture-independent microbiology methods such as high-throughput sequencing became available, important aspects of host-bacterium interactions will be elucidated. Based on microbiological relevance, .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.40
- DOI:
- 10.4238/2015.November.18.40
Serial analysis of gene expression in adenocarcinoma samples and normal colonic mucosa in a Chinese population
Authors: X.L. Zhang, F. Gao, W. Li, W.Z. Tang and S. Zhang
The goal of this study was to identify the differences in gene expression between adenocarcinoma samples and colonic normal mucosa of a Chinese population. Gene expression libraries of adenocarcinoma and normal colonic mucosa were generated by serial analysis of gene expression (SAGE). Expression tags were obtained from sequencing results using the SAGE20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.11
- DOI:
- 10.4238/2015.October.21.11
Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma
Authors: Y.-J. Hu, X.-Y. Luo, Y. Yang, C.-Y. Chen, Z.-Y. Zhang and X. Guo
The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.9
- DOI:
- 10.4238/2015.November.30.9
CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis
Authors: H.W. Lu, M. Huang, J.H. Wang, X.L. Sun and Y.Q. Ke
The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.20
- DOI:
- 10.4238/2015.October.5.20
Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro
Authors: M. Yue, X.J. Shen, Y.X. Liu, X.Y. Lin, S.Q. Zhou and Y.H. Song
Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We inve.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.12
- DOI:
- 10.4238/2015.November.30.12
Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer
Authors: J. Li, X.F. Jia, J. Liu, J.J. Liu and H.B. Zhao
The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.5
- DOI:
- 10.4238/2015.October.5.5
Interferon-�±-2b as an adjuvant therapy prolongs survival of patients with previously resected oral muscosal melanoma
Authors: R. Wang , G. Jing, J. Lv, H. Song, C. Li, X. Wang, W. Xia, Y. Wu, G. Ren and W. Guo
Two major subtypes of melanoma include cutaneous melanoma and mucosal melanoma. The latter type is rare and usually occurs in the head and neck region. High-dose interferon-α-2b (IFN-α-2b) has proven effective in the treatment of cutaneous melanoma. Recently, a regimen of temozolomide plus cisplatin was reported mo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.8
- DOI:
- 10.4238/2015.October.5.8
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals
Authors: L.L. Gao, X. Ding, D.M. Xie, M. Yang and B.R. Dong
The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We include.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.22
- DOI:
- 10.4238/2015.November.30.22