Human Genetics

Physical and chemical characteristics of pitaya fruits at physiological maturity

Authors: T.A. Ortiz and L.S.A. Takahashi

The aim of this study was to analyze the physical and chemical characteristics of the maturation process of pitaya fruit (Hylocereus undatus) to identify indicators that can be used to determine the point of physiological maturity and establish the optimal timing of physiological maturity for harvesting the fruit. A completely randomized experimental desi.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.5

DOI:

10.4238/2015.November.18.5

Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice

Authors: Z.T. Shen, X.H. Wu, L. Wang, B. Li, X.X. Zhu

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.10

DOI:

10.4238/2015.December.1.10

SET8 expression is associated with overall survival in gastric cancer

Authors: X.L. Shi, Z.J. Guo, X.L. Wang, X.L. Liu, G.F. Shi

Genet. Mol. Res. 14(4):

2015.December.1.12

DOI:

10.4238/2015.December.1.12

Determination of patellar ligament and anterior cruciate ligament geometry using MRI

Authors: H.P. Wang, H.K. Cui, W. Yue, R.F. Yan, J.P. Ren, Z.S. Zhai, C.H. Liang, R.M. Yang and D.M. Han

Ligament geometry is crucial to surgical treatment success in anterior cruciate ligament (ACL) injury. This study aimed to optimize the MRI technique to elucidate the geometry of the patellar ligament (PL) and ACL in vivo. A 1.5-T superconducting MRI system with a special surface coil and fast spin echo was used to acquire hig.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.1

DOI:

10.4238/2015.October.16.1

Association of interleukin gene polymorphisms with the risk of coronary artery disease

Authors: H.T. Yang, S.L. Wang, L.J. Yan, P. Qian and H.Y. Duanb

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrol.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.16

DOI:

10.4238/2015.October.16.16

Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population

Authors: T.B. Jin, X.J. Xun, X.G. Shi, D.Y. Yuan, T. Feng, T.T. Geng and L.L. Kang

Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China. Subsequently, we compared the.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.17

DOI:

10.4238/2015.October.16.17

`Identification of the origin of marker chromosomes by two-color fluorescence in situ hybridization and polymerase chain reaction in azoospermic patients

Authors: C.L. Wei1, J.L. Cheng, W.C. Yang, L.Y. Li, H.C. Cheng and J.J. Fu1

Y chromosomal microdeletions at the azoospermia factor locus and chromosome abnormalities have been implicated as the major causes of idiopathic male infertility. A marker chromosome is a structurally abnormal chromosome in which no part can be identified by cytogenetics. In this study, to identify the origin of the marker chromosomes and to perform a gen.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.11

DOI:

10.4238/2015.November.18.11

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis

Authors: G.G. Song and Y.H. Lee

The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic.. Read More»

Genet. Mol. Res. 13(4):

Differentiated evolutionary relationships among chordates from comparative alignments of multiple sequences of MyoD and MyoG myogenic regulatory factors

Authors: L.C. Oliani, K.C.F. Lidani and J.E. Gabriel

MyoD and MyoG are transcription factors that have essential roles in myogenic lineage determination and muscle differentiation. The purpose of this study was to compare multiple amino acid sequences of myogenic regulatory proteins to infer evolutionary relationships among chordates. Protein sequences from Mus musculus (P10085 .. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.23

DOI:

10.4238/2015.October.16.23

Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro

Authors: J.W. Wu, J.J. Wang, J.B. Chen, Y.L. Huang, H. Wang, G.H. Liu,L.F. Li, M. Kang, X.G. Wang and H.H. Cai

Intervertebral disc degeneration is the main cause of lumbago disease, in which the extracellular matrix structure and moisture in the nucleus pulposus is lost continuously. In this study, we aimed to detect differential expression of silence mating type information regulation 2 homolog 1 (SIRT1) and matrix metalloproteinase-1.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.5

DOI:

10.4238/2015.October.16.5