Human Genetics
Gene annotation and functional analysis of a newly sequenced Synechococcus strain
Authors: Y. Li, N.N. Rao, Y. Yang, Y. Zhang and Y.N. Gu
Synechococcus sp PCC 7336 represents a newly sequenced strain, and its genome is obviously different from that of other Synechococcus strains. In this analysis, local alignment and annotation databases were constructed and combined with various bioinformatic tools to carry out gene annotation and functional analysis of this st.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.8
- DOI:
- 10.4238/2015.October.16.8
Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis
Authors: X.D. Li, G.F. Sun, W.B. Zhu and Y.H. Wang
The aim of this study was to investigate the impact of high intensity exhaustive exercise on nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) expression in rats with knee osteoarthritis. Sprague Dawley rats were randomly divided into control (N = 5) and model (N = 35) groups; the model group was further.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.3
- DOI:
- 10.4238/2015.October.16.3
Association between hypoxia-inducible factor-1a levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis
Authors: H. Chu, Z.M. Xu, H. Yu, K.J. Zhu and H. Huang
Osteoarthritis (OA) is primarily characterized by articular cartilage degradation. Hypoxia-inducible factor-1a (HIF-1a), a subunit of the basic helix-loop-helix-containing PER-ARNT-SIM (PAS) domain transcription factors, plays a vital role in the survival of articular chondrocytes to the hostile hypoxic microenvironment and complicates the progression of .. Read More»
- Genet. Mol. Res. 13(4):
Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis
Authors: G.-Y. Zhang1, M. Chen1, Z.-M. Yu1, X.-D. Wang2 and Z.-Q. Wang1
This study aimed to investigate the relation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis. A total of 219 patients were included in the study, comprising 51 coronary artery atherosclerosis (CAC) patients, 92 stable angina pectoris (SAP) patients, and 76 acute coronary syndrome (ACS) patients. Based on the r.. Read More»
- Genet. Mol. Res. 13(4):
Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells
Authors: S.F. Chen, Z.Y. Zhang and J.L. Zhang
It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATPâÂ?Â?binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.18
- DOI:
- 10.4238/2015.November.18.18
Effect of Bcl-2-siRNA on proliferation and apoptosis of pediatric acute B lymphoblastic leukemia (A-BLL) cells
Authors: W.B. Meng, J.P. Liu, X.W. Wang and L.H. E
This study analyzed the effect of small interfering RNA specific for the Bcl-2 gene (siRNA Bcl-2) on the proliferation and chemotherapeutic sensitivity of pediatric A-BLL cells. Marrow samples were obtained from sixty newly-diagnosed A-BLL pediatric patients. The Bcl-2 mRNA expression in these samples was quantified by real ti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.9
- DOI:
- 10.4238/2015.October.16.9
A retrospective analysis of surgical treatment of mesh infection after repair of ventral hernia or defect
Authors: F.-D. Liu, J.-Y. Li, S. Yao and Y. Zhang
This study aimed to summarize our experience in surgical treatment of mesh infection after repair of ventral hernia or defect. A retrospective analysis was conducted on clinical data of 22 patients who accepted surgical treatment of mesh infection after ventral hernia or defect repair. Included were 16 cases of infection after incisional hernia repair, 5 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.2
- DOI:
- 10.4238/2015.November.18.2
Correlation between chromosomal polymorphisms and male infertility in a Northeast Chinese population
Authors: L.L. Li, D. Peng, R.X. Wang, H.B. Zhu, W.J. Wang, R.Z. Liu
The aim of this study was to evaluate the correlation between chromosomal polymorphisms and male infertility. The patients were diagnosed with azoospermia or oligospermiaby a semen analysis. Chromosomal analysis was performed on peripheral blood lymphocytes obtained from the patients, with standard G-banding and C-banding. Y c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.21
- DOI:
- 10.4238/2015.November.30.21
miR-577 inhibits pancreatic �²-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes
Authors: X.Y. Chen, G.M. Li, Q. Dong, H. Peng
Pancreatic β-cell dysfunction is a central component of the pathogenesis of pediatric diabetes. MicroRNA (miRNA) have become one of the most encouraging and fruitful fields in biological research, and have been implicated as new players in the pathogenesis of diabetes and diabetes-associated complications. The role of miR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.24
- DOI:
- 10.4238/2015.November.30.24
Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis
Authors: X. Zhang, C. Zheng, Z.H. Zhou, M. Li, Y.T. Gao, S.G. Jin,X.H. Sun, Y.Q. Gao
The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies publi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.6
- DOI:
- 10.4238/2015.December.1.6