Human Genetics
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
Authors: P.L. Chen, W.T. Li, J. Wang, Y.D. Jiang, P. Wu, T. Chen and S.B. Zheng
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.29
- DOI:
- 10.4238/2015.December.29.29
Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis
Authors: L. Yan, R. Hu, S. Tu, W.J. Cheng, Q. Zheng, J.W. Wang, W.S. Kan and Y.J. Ren
Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.32
- DOI:
- 10.4238/2015.December.29.32
Correlation between matrix metalloproteinase-9 and vascular endothelial growth factor expression in lung adenocarcinoma
Authors: Y.L. Wen and L. Li
The aim of this study was to investigate the correlation between the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) and clinicopathological features of lung adenocarcinoma. The expression of MMP-9 and VEGF was evaluated by immunohistochemistry of 30 samples from lung adenocarcinoma patients and 12 paratumora.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.44
- DOI:
- 10.4238/2015.December.29.44
Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration
Authors: J. Li, H.L. Tang, Y. Chen, Q. Fan, Y.T. Shao, M. Jia, J.C. Wang and C.M. Yang
The aim of this study was to investigate the impacts of positive acceleration (+Gz) on the gastric mucosal tissues in cases of acute gastric mucosal injury and to explore the role of oxygen free radicals. Thirty Sprague Dawley rats were randomly divided into the absolute ethanol control group (A group), absolute et.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.9
Using bradykinin-potentiating peptide structures to develop new anti hypertensive drugs
Authors: Jorge Hernandez Fernandez, Goran Neshich and Antonio Carlos M. Camargo
Angiotensin I-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase expressed in endothelial, epithelial and neuroepithelial cells. It is composed of two domains, known as N- and C-domains, and it is primarily involved in blood pressure regulation. Although the physiological functions of ACE are not limited to its cardiovas.. Read More»
- Genet. Mol. Res. 3(4):
The olfactory receptor universe - from whole genome analysis to structure and evolution
Authors: Tsviya Olender, Ester Feldmesser, Tal Atarot, Miriam Eisenstein and Doron Lancet
Olfactory receptors (ORs) constitute the largest gene-family in the vertebrate genome. We have attempted to provide a comprehensive view of the OR universe through diverse tools of bioinformatics and computational biology. Among others, we have constructed the Human Olfactory Receptor Data Exploratorium (HORDE, http://bioporta.. Read More»
- Genet. Mol. Res. 3(4):
A bioinformatics analysis of alternative exon usage in human genes coding for extracellular matrix proteins
Authors: Noboru Jo Sakabe, Maria Dulcetti Vibranovski and Sandro Jos�© de Souza
Alternative splicing increases protein diversity through the generation of different mRNA molecules from the same gene. Although alternative splicing seems to be a widespread phenomenon in the human transcriptome, it is possible that different subgroups of genes present different patterns, related to their biological roles. An.. Read More»
- Genet. Mol. Res. 3(4):
A novel human G protein-coupled receptor is over-expressed in prostate cancer
Authors: Raphael B. Parmigiani, Geraldo S. Magalh�£es, Pedro A.F. Galante,Carina V.B. Manzini, Anamaria A. Camargo and Bettina Malnic
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the i.. Read More»
- Genet. Mol. Res. 3(4):
Splicing factors are differentially expressed in tumors
Authors: Natanja Kirschbaum-Slager, Graziela M.P. Lopes, Pedro A.F. Galante, Gregory J. Riggins and Sandro J. de Souza
Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated,.. Read More»
- Genet. Mol. Res. 3(4):
Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequences
Authors: Elisa N. Ferreira, Lilian C. Pires, Raphael B. Parmigiani,Fabiana Bettoni, Renato D. Puga, Daniel G. Pinheiro,LuÃ?Âs Eduardo C. Andrade, Luciana O. Cruz, Theri L. Degaki,Milton Faria Jr., Fernanda Festa, Daniel Giannella-Neto,Ricardo R. Giorgi, Gustavo H. Goldman, Fabiana Granja,Arthur Gruber, Christine Hackel, FlÃ?¡vio Henrique-Silva,Bettina Malnic, Carina V.B. Manzini, Suely K.N. Marie14,Nilce M. Martinez-Rossi15, Sueli M. Oba-Shinjo14,Maria Ines M.C. Pardini16, Paula Rahal18, ClÃ?¡udia A.Rainho,Silvia R. Rogatto, Camila M. Romano, Vanderlei Rodrigues,Magaly M. Sales, Marcela Savoldi8, Ismael D.C.G. da Silva,Neusa P. da Silva, Sandro J. de Souza, Eloiza H. Tajara,Wilson A. Silva Jr, Andrew J.G. Simpson, Mari C. Sogayar,Anamaria A. Camargo and Dirce M. Carraro
The correct identification of all human genes, and their derived transcripts, has not yet been achieved, and it remains one of the major aims of the worldwide genomics community. Computational programs suggest the existence of 30,000 to 40,000 human genes. However, definitive gene identification can only be achieved by experim.. Read More»
- Genet. Mol. Res. 3(4):