Human Genetics
Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia
Authors: Q.Y. Liu, F.Y. Gao, X.R. Liu, J. Li, M. Ji, J. Dong and X.T. Wang
In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.42
- DOI:
- 10.4238/2015.December.29.42
Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis
Authors: H.S. Zhu, J.F. Zhang, J.D. Zhou, M.J. Zhang and H.X. Hu
Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independent.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.43
- DOI:
- 10.4238/2015.December.29.43
Two novel ATP2C1 mutations in patients with Hailey-Hailey disease and a literature review of sequence variants reported in the Chinese population
Authors: L. Meng, Y. Gu, X.F. Du, M.H. Shao, L.L. Zhang, G.L. Zhang and X.L. Wang
Hailey-Hailey disease (HHD) is an autosomal dominant disorder in which the ATP2C1 gene has been implicated. Many mutations of this gene have been detected in HHD patients. To analyze such mutations in HHD and summarize all those identified in Chinese patients with this disease, we examined four familial and two sporadic cases and searched for case reports.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.45
- DOI:
- 10.4238/2015.December.29.45
Correlation between serum YKL-40 levels and albuminuria in type 2 diabetes
Authors: J.Y. Han, X.Y. Ma, L.J. Yu, Y. Shao and Q.Y. Wang
We explored the correlation between serum YKL-40 levels and albuminuria in type 2 diabetes mellitus (T2DM) and its clinical significance. This study used a cross-sectional survey method. According to the American Diabetes Association 2007 Clinical Practice Recommendations, 738 patients with T2DM were divided into three groups: a normoalbuminuria group [al.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.7
- DOI:
- 10.4238/2015.December.28.7
Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people
Authors: J.N. Xue, Y. Guo, X. Song, F. Xue, S.F. Yang, H. Jiang, R.Z.W.A. Bu-La and C. Lu
We explored the relationship between rs1047763, a single-nucleotide polymorphism (SNP) of the C1GALT1 gene, and genetic susceptibility to immunoglobulin A nephropathy (IgAN) in Xinjiang Uyghur people. The study comprised 90 patients with IgAN and 90 normal controls recruited from Uyghur people. The distribution of the rs1047763 polymorphism of C1GALT1 in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.17
- DOI:
- 10.4238/2015.December.28.17
Effect of transvaginal ultrasound on human chorionic villus cell apoptosis during pregnancy
Authors: X.L. Qu, H.T. Wang, J.L. Zou, L. Cheng, F. Wang, L.L. Ma and J. Li
With the advancement of ultrasonic technology in recent years, sonography has become a common medical diagnostic tool, as it has elevated output sonic intensity and elongated exposure time. This study investigates the effect of ultrasound on human chorionic villus cell apoptosis during early pregnancy. Transvaginal ultrasound was performed for a total of .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.26
- DOI:
- 10.4238/2015.December.28.26
Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer
Authors: Y.P. Zhao, W. Wang, X.H. Wang, Y. Xu, Y. Wang, Z.F. Dong and J.J. Zhang
The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers. However, the serum level of DKK-1 in patients with papillary thyroid cancer (PTC) and its potential clinical significance is poorly understood. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.38
- DOI:
- 10.4238/2015.December.28.38
Effect of sinomenine on the expression of rheumatoid arthritis fibroblast-like synoviocytes MyD88 and TRAF6
Authors: H.C. Zhang, M.X. Liu, E.P. Wang, Z. Lin, G.F. Lv and X. Chen
The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated. SIN inhibition of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) proliferation and RA cartilag.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.41
- DOI:
- 10.4238/2015.December.28.41
miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2
Authors: Y. Xia, J. Sheng, G.Y. Liang, D.X. Liu, Q. Tang and A.P. Cheng
Increasing evidence has indicated that microRNAs are involved in the pathogenesis of cardiac hypertrophy. However, whether miR-96 is involved in heart diseases, particularly cardiac hypertrophy, remains unclear. In this study, we found that miR-96 is a negative regulator of cardiac hypertrophy. In primary cardiomyocytes, overexpression of miR-96 inhibited.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.2
- DOI:
- 10.4238/2015.December.29.2
Role of ACE and AGT gene polymorphisms in genetic susceptibility to diabetes mellitus type 2 in a Brazilian sample
Authors: L.M. Wollinger, S.M. Dal Bosco, C. Rempel, S.E.M. Almeida, D.B. Berlese, R.P. Castoldi, M.E. Arndt, V. Contini and J.P. Genro
The aim of the current study was to investigate the association between the InDel polymorphism in the angiotensin I-converting enzyme gene (ACE) and the rs699 polymorphism in the angiotensinogen gene (AGT) and diabetes mellitus type 2 (DM2) in a sample population from Southern Brazil. A case-control study was conducted with 228 patients with DM2 and 183 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.20
- DOI:
- 10.4238/2015.December.29.20