Human Genetics
Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy
Authors: X. Li, C.Y. Liu, Y.S. Li, J. Xu, D.G. Li, X.I. Li and D. Han
Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027465
- DOI:
- 10.4238/gmr.15027465
Bee�s morphometrics and behavior in response to seasonal effects from ecoregions
Authors: A.R.S. Sousa, E.D. Ara�ºjo, K.P. Gramacho and L.A. Nunes
In the present study, we used morphological and behavioral analyses to assess the effects of seasonality and morphoclimatic patterns on the morphology, behavior, and distribution of 71 colonies of Africanized honey bees in 3 distinct ecoregions (Zona da Mata, Agreste, and Sertão) within the State of Sergipe, north-easte.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027597
- DOI:
- 10.4238/gmr.15027597
Frequency of TLR4 (1063A/G and 1363C/T) polymorphisms in healthy and HIV-infected Omani individuals and their relationship to viral load and T cell count
Authors: E.A. Said, F. Al-Yafei, F. Zadjali, M.S. Al-Balushi, S.S. Hasson, S.H. Al-Mahroqi, C.Y. Koh, K. Al-Naamani, J.Z. Al-Busaidi, M.A. Idris, A. Balkhair and A.A. Al-Jabri
Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027671
- DOI:
- 10.4238/gmr.15027671
Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease
Authors: A. Etemad, R. Vasudevan, A.F.A. Aziz, A.K.M Yusof, S. Khazaei, N. Fawzi, S. Jamalpour, M. Arkani, N.A. Mohammad and P. Ismail
Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025845
- DOI:
- 10.4238/gmr.15025845
Efficient use of artificial micro-RNA to downregulate the expression of genes at the post-transcriptional level in Arabidopsis thaliana
Authors: A. Ud-Din, M. Rauf, S. Ghafoor, M.N.K. Khattak, M.W. Hameed, H. Shah, S. Jan, K. Muhammad, A. Rehman and Inamullah
icro-RNAs are cellular components regulating gene expression at the post-transcription level. In the present study, artificial micro-RNAs were used to decrease the transcript level of two genes, AtExpA8 (encoding an expansin) and AHL25 (encoding an AT-hook motif nuclear localized protein) in Arabidopsis thaliana. The backbone .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027439
- DOI:
- 10.4238/gmr.15027439
Anti-tumor activity of dendritic cell-cytokine induced killer cells (DC-CIKs) sensitized to HER2 against HER-positive breast cancer cells
Authors: Y.Y. Wen and X.S. Hu
This study aimed to investigate the cytotoxicity of cytokine-induced killer cells (CIKs) and Her2 epitope peptide-sensitized dendritic cells (DCs), when co-cultured with Her2-positive MCF-7 cells. DCs were separated from the Her epitope peptide-sensitized peripheral blood; the Her epitope combines directly with the MHC-II mole.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027853
- DOI:
- 10.4238/gmr.15027853
Mitochondrial DNA COI characterization of Helicoverpa armigera (Lepidoptera: Noctuidae) from Paraguay and Uruguay
Authors: J.A. Arnemann, W.J. James, T.K. Walsh, J.V.C. Guedes, G. Smagghe, E. Castiglioni and W.T. Tay
Since its detection in Brazil in 2013, the Old World cotton bollworm Helicoverpa armigera has been reported in Argentina, Paraguay, and Bolivia. Here we present evidence extending the South American range of H. armigera to Uruguay, using polymerase chain reaction and sequencing of the partial mitochondrial DNA (mtDNA) cytochro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028292
- DOI:
- 10.4238/gmr.15028292
Structure of mitochondrial DNA control region and genetic diversity of Moschus berezovskii populations in Shaanxi Province
Authors: H. Feng, C.L. Feng, Y. Huang and J. Tang
In China, Moschus berezovskii (forest musk deer), a first-class national protected animal, was earlier widely distributed. However, wild populations of the forest musk deer have declined because of human activity and habitat loss. In order to gather useful information for its conservation and management, we investigated the ge.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027578
- DOI:
- 10.4238/gmr.15027578
MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation
Authors: Y. Yang, L.J. Yang, M.Z. Deng, Y.Y. Luo, S. Wu, L. Xiong, D. Wang,Y. Liu and H. Liu
Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochra.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027615
- DOI:
- 10.4238/gmr.15027615
Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer
Authors: L. Liu, T. Meng, Q.S. Wang, H.Z. Jin, Z.Q. Sun, B. Jin, F. Fang and H.J. Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance o.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027704
- DOI:
- 10.4238/gmr.15027704