Human Genetics
Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer
Authors: Z.H. Chen, L. Wang and L.P. Luo
We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimentary group 1 gene (ERCC1) and xeroderma pigmentosum complementation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer. Samples from a total of 255 patients with.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.15
- DOI:
- 10.4238/2014.September.12.15
Polymorphisms in the PPAR�³ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China
Authors: J. Chen, R.L. Ma, H. Guo, Y.S. Ding, J.Y. Zhang, J.M. Liu, M. Kerm, M. Zhang, S.Z. Xu, S.G. Li and S.X. Guo
We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARγ gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. Mass spectrometry techniques were used to detect the PPARγ genotypes rs1801282 and rs3856806 in 987 subjects, CC genotype and C allele frequencies were 83.6 and 91.7%, respectively, at rs1801282.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.1
- DOI:
- 10.4238/2015.June.11.1
Meta-analysis of TAFI polymorphisms and risk of cardiovascular and cerebrovascular diseases
Authors: S.W. Wang, H.H. Zhang, C.Y. Dong and H.H. Sun
Cardiovascular and cerebrovascular diseases (CCVDs) are common and have high rates of morbidity, mortality, and recurrence. Thrombin-activatable fibrinolysis inhibitor (TAFI) is also known as carboxypeptidase B2 and is encoded by the CPB2 gene; CPB2 polymorphisms have been explored in a variety of studies, but their correlatio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026718
- DOI:
- 10.4238/gmr.15026718
Effects of monomethoxypolyethylene glycol-chitosan nanoparticle-mediated dual silencing of livin and survivin genes in prostate cancer PC-3M cells
Authors: A.Q. Yang, P.J. Wang, T. Huang, W.L. Zhou and J. Landman
Monomethoxypolyethylene glycol-chitosan (mPEG-CS) nanoparticles were used as interfering RNA carriers to transfect human prostate cancer PC-3M cells to evaluate the effects of livin and survivin gene silencing on the proliferation and apoptosis. mPEG-CS nanoparticles with sizes of approximately 60 nm were first synthesized by .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027430
- DOI:
- 10.4238/gmr.15027430
Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis
Authors: S. Denden, B. Bouden, A. Haj Khelil, J. Ben Chibani and M.H. Hamdaoui
The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar dat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027487
- DOI:
- 10.4238/gmr.15027487
Comparative proteomic analysis of ductal and lobular invasive breast carcinoma
Authors: N.C.S. Oliveira, T.H.B. Gomig, H.H. Milioli, F. Cordeiro, G.G. Costa, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027701
- DOI:
- 10.4238/gmr.15027701
Post-transcriptional silencing of the SGE1 gene induced by a dsRNA hairpin in Fusarium oxysporum f. sp cubense, the causal agent of Panama disease
Authors: J.S. Fernandes, P.C.S. Angelo, J.C. Cruz, J.M.M. Santos, N.R. Sousa and G.F. Silva
Fusarium oxysporum f. sp cubense (Foc), the causal agent of Panama disease, is responsible for economic losses in banana crops worldwide. The identification of genes that effectively act on pathogenicity and/or virulence may contribute to the development of different strategies for disease control and the production of resista.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027941
- DOI:
- 10.4238/gmr.15027941
Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression
Authors: Z. Peng and Y. Zhang
Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027078
- DOI:
- 10.4238/gmr.15027078
Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis
Authors: N. Wang, P. Chen, L.P. Huang and T.Z. Wang
Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027350
- DOI:
- 10.4238/gmr.15027350
135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis
Authors: L. Wu, Z.G. Long and Z.S. Dai
Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027383
- DOI:
- 10.4238/gmr.15027383