Human Genetics
Role of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in polycystic ovary syndrome risk
Authors: J.B. Wu, J.F. Zhai and J. Yang
Polycystic ovary syndrome is one of the most frequently encountered endocrine malfunctions. Methylenetetrahydrofolate reductase (MTHFR) plays a vital role in folate metabolism, DNA methylation, and RNA synthesis. We carried out a study to investigate the association between MTHFR C677T and A1298C genetic variations and the ris.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048570
- DOI:
- 10.4238/gmr15048570
ABCB1 gene expression in peripheral blood mononuclear cells in healthy Thai males and females
Authors: P. Sudchada, S. Oo-puthinan, O. Kerdpin and N. Saelim
We compared the expression of the ABCB1 gene in healthy male and female Thai subjects; this gene encodes the P-glycoprotein transporter in peripheral blood mononuclear cells (PBMCs). We also identified the most suitable housekeeping genes for normalization of ABCB1 expression levels in PBMCs. PBMCs from 30 females and 26 males.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr813
- DOI:
- 10.4238/vol9-2gmr813
Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women
Authors: A. GonzÃ?¡lez-Mercado, J.Y. SÃ?¡nchez-LÃ?³pez, J.A. Regla-Nava,a, J.I. GÃ?¡mez-Nava, L. GonzÃ?¡lez-LÃ?³pez, J. DurÃ?¡n-GonzÃ?¡lez, A. Celis, F.J. Perea-DÃ?Âaz, M. Salazar-PÃ?¡ramo and B. Ibarra
We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified according to World .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.13
- DOI:
- 10.4238/2013.July.30.13
MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis
Authors: J.Z. Guan, M. Wu, Y.Z. Xiao, J.S. Zhou and Z.D. Wang
Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seve.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.1
- DOI:
- 10.4238/2014.September.12.1
Correlation between hepcidin level and renal anemia
Authors: L.-N. Yang, P. Zhang, F. Tang, G. Wang and F.-E. Li
Anemia in patients with chronic renal insufficiency (CRI) is related to the chronic inflammatory state, low iron absorption rate, and low utilization rate. As a key protein for iron metabolism, hepcidin plays an important role in CRI anemia. The study aimed to determine the correlation between hepcidin level and renal anemia. .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.6
- DOI:
- 10.4238/2014.September.12.6
Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population
Authors: Y. Cao, J. Hu, Y. Fang, Q. Chen and H. Li
Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cance.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.8
- DOI:
- 10.4238/2014.September.12.8
Antioxidant content and cytological examination of aqueous fluid from patients with age-related cataracts at different stages
Authors: X. Wang, J. Sun, G.F. Dang, Y. Gao, L. Duan and X.Y. Wu
We investigated the antioxidant content and conducted a cytological examination of the aqueous fluid and lenses of patients with age-related cataracts at different stages. The levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHPX) in the aqueous fluid and lenses were determined by the xanthine oxidase method, the colorime.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.11
- DOI:
- 10.4238/2015.June.9.11
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer
Authors: X. Tan, Y.Y. Wang, X.Y. Chen, L. Xian, J.J. Guo1, G.B. Liang and M.W. Chen
The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-a.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.10
- DOI:
- 10.4238/2014.September.12.10
Metastatic renal cell carcinoma to the left maxillary sinus
Authors: Y.-F. He, J. Chen, W.-Q. Xu, C.-S. Ji, J.-P. Du, H.-Q. Luo and B. Hu
Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.12
- DOI:
- 10.4238/2014.September.12.12
Distribution of CXCR2 +1208 T/C gene polymorphisms in relation to opportunistic infections among HIV-infected patients in Limpopo Province, South Africa
Authors: A. Samie, G.A. Dzhivhuho and T.C. Nangammbi
Interleukin 8 (IL-8) is a chemokine produced by macrophages and other cell types, including epithelial cells, and its receptor is CXCR2. IL-8 plays an important role in the initiation and amplification of inflammatory diseases, including opportunistic infections. With the advent of human immunodeficiency virus (HIV) and acquir.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.13
- DOI:
- 10.4238/2014.September.12.13