Human Genetics
Genetic relationship between lodging and lodging components in barley (Hordeum vulgare) based on unconditional and conditional quantitative trait locus analyses
Authors: W.Y. Chen, Z.M. Liu, G.B. Deng1, Z.F. Pan, J.J. Liang, X.Q. Zeng, N.M. Tashi, H. Long and M.Q. Yu
Lodging (LD) is a major constraint limiting the yield and forage quality of barley. Detailed analyses of LD component (LDC) traits were conducted using 246 F2 plants generated from a cross between cultivars ZQ320 and 1277. Genetic relationships between LD and LDC were evaluated by unconditional and conditional quantitative tra.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.19
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.19
Reversal effect of vitamin D on different multidrug-resistant cells
Authors: M. Yan and H. Nuriding
We investigated the reversal effect of vitamin D on the multidrug-resistant leukemic Jurkat/ADR and K562/ADR cell lines and conducted a preliminary investigation of its reversal mechanism. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to detect the reversal effect of vitamin D on multid.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.6
- DOI:
- 10.4238/2014.August.15.6
Molecular characterization of microduplication 22q11.2 in a girl with hypernasal speech
Authors: Y. Soysal, J. Vermeesch, N.A. Davani, N. ��ensoy, K. Hekimler and N. �°mirzal�±o��lu
We present a 12-year-old girl with karyotype 46,XX. A comparative genomic hybridization array revealed a 3.172-Mb microduplication on 22q11.2. This chromosome 22q11.2 region microduplication has been described in patients with variable phenotypes; a large majority of them have identical 3-Mb duplications. The girl presented mi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1339
- DOI:
- 10.4238/vol10-3gmr1339
MtDNA variability in whitefly (Bemisia tabaci) populations in Brazil
Authors: G.E. Valle, A.L. Louren�§�£o, M.I. Zucchi, J.B. Pinheiro and A.G. Abreu
Bemisia tabaci (Hemiptera: Aleyrodidae) consists of a complex of morphologically indistinct biotypes that vary mainly in their capacity to transmit plant viruses and to induce physiological disorders in plants of economic importance. The adaptability of B. tabaci to many regions of the world has fostered the appearance of vari.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1183
- DOI:
- 10.4238/vol10-3gmr1183
Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells
Authors: H. Zhang, F. Chen, G.L. Li, Y.Y. Ding, Z.R. Tao, J.J. Li,S.L. Zhong and L.Z. Lu
Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.20
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.20
Circulatory microRNA-145 expression is increased in cerebral ischemia
Authors: C.S. Gan, C.W. Wang and K.S. Tan
Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression .. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.27.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.27.1
HIV TAT variants differentially influence the production of glucocerebrosidase in Sf9 cells
Authors: Andrea K. Vaags, Tessa N. Campbell and Francis Y.M. Choy
Gaucher disease, the most common lysosomal storage disorder, is currently treated with enzyme replacement therapy. This approach, however, is ineffective in altering the progression of neurodegeneration in type 2 and type 3 patients due to the difficulty of transferring the recombinant enzyme across the blood-brain barrier. Hu.. Read More»
- Genet. Mol. Res. 4(3):
Philadelphia-negative chromosomal evolution during treatment for chronic myeloid leukemia
Authors: H.-H. Hsiao, Y.-C. Liu, C.-P. Lee, C.-S. Chang and S.-F. Lin
Chromosome evolution is one of the major mechanisms of disease progression and resistance in chronic myeloid leukemia (CML) patients. However, the clinical significance of chromosomal evolution in the Philadelphia (Ph)-negative clone during therapy is not fully understood. We evaluated 94 CML patients in the chronic phase of C.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.February.10.2
- DOI:
- http://dx.doi.org/10.4238/2012.February.10.2
Association of eNOS gene polymorphisms with essential hypertension in the Han population in southwestern China
Authors: J. Li, Y. Cun, W.R. Tang, Y. Wang, S.N. Li, H.R. Ouyang, Y.R. Wu, H.J. Yu and C.J. Xiao
Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Polymorphisms in the eNOS gene have been found to be associated with hypertension in different human populations, including Northern and Southern Chinese Han populations. To examine the relationshi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1160
- DOI:
- 10.4238/vol10-3gmr1160
Association between dopamine D2 receptor gene polymorphisms and the risk of heroin dependence
Authors: N. Wang1*, J.B. Zhang1*, J. Zhao1, X.T. Cai1, Y.S. Zhu1,2 and S.B. Li1,2
Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and s.. Read More»
- Genet. Mol. Res. 15(4):
- http://dx.doi.org/gmr15048772
- DOI:
- http://dx.doi.org/10.4238/gmr15048772