Human Genetics
Effects of intra- and extracellular factors on anti-aging klotho gene expression
Authors: K. Turan and P. Ata
Inactivation of the klotho gene in mice causes serious systemic disorders, resembling human aging. However, at the molecular level, its action mechanisms are not well understood. The stimulatory or inhibitory effects of cis- and trans-regulatory factors on the klotho gene expression are also still unclear. We studied the effec.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1261
- DOI:
- 10.4238/vol10-3gmr1261
A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico
Authors: L. GarcÃ?Âa-Ortiz, G. Vargas-AlarcÃ?³n, J.M. Fragoso, J. Granados, L. Maldonado Noriega, A. Navas PÃ?©rez , E. Huerta Reyes, J.C. Zenteno-Ruiz and E. MartÃ?Ânez-Cordero
The human orosomucoid 1 gene (ORM1) codes an alpha-1-acid glycoprotein that has been classified as an acute-phase reactive protein, and a major drug-binding serum component, as well as an immunomodulatory protein with genetic polymorphisms. Evaluation of ORM variation through isoelectric focusing and immunobloting has revealed a world-wide distribution of.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr348
- DOI:
- 10.4238/vol7-1gmr348
Stable transfection and identification of a hair follicle-specific expression vector of IGFBP-5 in goat fetal fibroblasts
Authors: X.J. Wang, H.M. Su, Y. Liang, Y.F. Wang, X.D. Guo, Z.G. Wang and D.J. Liu
The insulin-like growth factor-binding protein-5 (IGFBP-5) is one of the 6 members of the IGFBP family and is involved in the regulation of cell growth, apoptosis, and other IGF-stimulated signaling pathways. To determine the significance of IGFBP-5 in the Inner Mongolia Cashmere goat (Capra hircus), a hair follicle-specific expression vector of IGFBP-5, .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.16
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.16
A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer
Authors: X.X. Lu, J.J. Hu, Y. Fang, Z.T. Wang, J.J. Xie, Q. Zhan, X.X. Deng, H. Chen, J.B. Jin, C.H. Peng, J. Liu, H.W. Li and B.Y. Shen
Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.30
- DOI:
- 10.4238/2014.August.7.30
Association between HLA-A and -B polymorphisms and susceptibility to Henoch-Sch�¶nlein purpura in Han and Mongolian children from Inner Mongolia
Authors: S.M. Ren, G.L. Yang, C.Z. Liu, C.X. Zhang, Q.H. Shou, S.F. Yu, W.C. Li and X.L. Su
We examined a possible association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura (HSP) in Han and Mongolian children in Inner Mongolia, through a case-control study. Two hundred and sixty-eight unrelated children were enrolled, including 56 Mongolian and 50 Han children with HSP, 66 hea.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.February.3.2
- DOI:
- http://dx.doi.org/10.4238/2012.February.3.2
Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population
Authors: Y. Guo, J.-T. Wang, H. Liu, M. Li, T.-L. Yang, X.-W. Zhang, Y.-Z. Liu, Q. Tian and H.-W. Deng
Osteoporosis is a heritable disease characterized mainly by low bone mineral density (BMD) and/or osteoporotic fractures (OF). Most genome-wide association studies on osteoporosis have focused on BMD, whereas little effort has been expended to identify genetic variants directly linked to OF. To determine whether BMD-loci are a.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.31.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.31.1
Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China
Authors: D.H. Huang, J.O. Zheng, J. Chen and L. Yu
This study aimed to investigate the prevalence and treatment gaps of epilepsy, as well as the clinical effects, drug safety, and retention rates of sodium valproate (VPA) for treating epilepsy. Physicians received supervised training to use the survey form recommended by the Chinese Association Against Epilepsy while screening.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.3
- DOI:
- 10.4238/2014.August.15.3
Gene expression analysis of demineralized bone matrix-induced osteogenesis in human periosteal cells using cDNA array technology
Authors: S. Honsawek, P. Bumrungpanichthaworn, T. Thitiset and L. Wolfinbarger Jr.
Demineralized bone matrix (DBM) has been widely investigated as a biomaterial to promote new bone formation and is utilized clinically for bone repair and regeneration. We investigated gene expression patterns of osteogenic differentiation in human periosteal (HPO) cells cultured with demineralized bone matrix, using cDNA arra.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1329
- DOI:
- 10.4238/vol10-3gmr1329
Isolation and characterization of polymorphic microsatellite loci of the Chinese muntjac (Muntiacus reevesi)
Authors: H. Wang, X. Luo, W.B. Shi and B.W. Zhang
Eight polymorphic microsatellite markers for Muntiacus reevesi were identified and characterized in this study. The number of alleles per locus ranged from 3 to 10 across 24-48 samples. The loci showed expected and observed heterozygosities of 0.577-0.876 and 0.387-0.933, respectively, with an average polymorphic information c.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.18
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.18
Common polymorphisms in the HIF-1�± gene confer susceptibility to digestive cancer: a meta-analysis
Authors: J.J. Xu, L.Y. Zou, L. Yang, X.L. He and M. Sun
Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our meta-analysis is aimed to derive a more precise estimation of the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.5
- DOI:
- 10.4238/2014.August.15.5