Human Genetics
STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer
Authors: B. Jiang, Z.Z. Zhu, F. Liu, L.J. Yang, W.Y. Zhang, H.H. Yuan, J.G. Wang, X.H. Hu and G. Huang
Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 po.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1071
- DOI:
- 10.4238/vol10-3gmr1071
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus
Authors: Y. Hu, W.L. Zhang, S.L. Xie, Y. Zhao, J.L. Hu, X.F. Cai, G.Q. Lai and A.L. Huang
Early detection of adefovir dipivoxil-resistant mutants during long-term treatment of chronic hepatitis B virus (HBV) infection with this drug is of great clinical importance. We developed an improved reverse dot hybridization test for simple and rapid detection of the rtA181V/T and rtN236T mutations associated with adefovir d.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.6
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.6
ms17: a meiotic mutation causing partial male sterility in a corn silage hybrid
Authors: M.S. Pagliarini, V.F. Souza, N. Silva, C.A. Scapim, M. Rodovalho and M.V. Faria
Cytological analysis under light microscopy of the single hybrid P30R50 of silage corn revealed an abnormal pattern of microsporogenesis that affected the meiotic products. Meiosis progressed normally until diakinesis, but before migration to the metaphase plate, bivalents underwent total desynapsis and 20 univalent chromosome.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1037
- DOI:
- 10.4238/vol10-3gmr1037
Module function and two-way clustering analysis of Epstein-Barr virus-related nasopharyngeal cancer
Authors: F. Chen, J. Liu, M. Fan, X.M. Wei, Y.L. Xie, L.H. Wang and H. Yang
This study sought to identify and characterize the function of genes as diagnostic markers for Epstein-Barr virus (EBV)-related nasopharyngeal cancer (NPC). The gene expression profile of GSE13597 was downloaded from the Gene Expression Omnibus database, which included 28 EBV-related NPC gene expression profile data sets, 25 d.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.10
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.10
Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling
Authors: H.-G. Zhang, X.-Y. Liu, Y. Hou, S. Chen1, S. Deng and R.-Z. Liu
Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6)(q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced t.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.11
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.11
Effect of 1,25-(OH)2D3 and lipopolysaccharide on mononuclear cell inflammation in type 2 diabetes mellitus and diabetic nephropathy uremia
Authors: E.L. Wu and H.X. Cui
The prevention and treatment of type-2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), which are disorders with high incidence rates, is of primary importance. In this study, we analyzed the effect of 1,25-(OH)2D3 and lipopolysaccharide (LPS) in combination with interleukin (IL)-15 on the inflammatory immune response a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038553
- DOI:
- 10.4238/gmr.15038553
Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population
Authors: Q.Y. Dong, X.M. Liu, C.G. Liang, W.H. Du, Y.L. Wang, W.X. Li and G.Q. Gao
Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of typ.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038559
- DOI:
- 10.4238/gmr.15038559
Apolipoprotein E polymorphism in elderly Japanese-Brazilian immigrants does not explain the reduced cardiovascular risk factor incidence
Authors: N. Terra, Y. Moriguchi, L. Bittencourt, R.S. Trois, J.E.C. Piccoli and I.B.M. Cruz
Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have live.. Read More»
- Genet. Mol. Res. 10(3):
Screening of differentially expressed genes between multiple trauma patients with and without sepsis
Authors: S.C. Ji, Y.T. Pan, Q.Y. Lu, Z.Y. Sun and Y.Z. Liu
The purpose of this study was to identify critical genes associated with septic multiple trauma by comparing peripheral whole blood samples from multiple trauma patients with and without sepsis. A microarray data set was downloaded from the Gene Expression Omnibus (GEO) database. This data set included 70 samples, 36 from mult.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.13
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.13
Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey
Authors: M.B. Yilmaz, A. Pazarbasi, A.I. Guzel, S. Kocaturk-Sel, H. Kasap, M. Kasap, I.F. Urunsak, S. Basaran, D. Alptekin and O. Demirhan
Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two co.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1204
- DOI:
- 10.4238/vol10-3gmr1204