Human Genetics
Combined analysis of the MspI and XbaI polymorphisms in intron 22 of the factor VIII gene for detection of hemophilia A in a Korean population.
Authors: S.H. Park, N. Chung, M.R. Lee, S.K. Yoo and Y.M. Choi
To determine the usefulness of MspI/int22h-1 (intron 22 homologous region-1) polymorphism of the factor VIII gene for molecular genetic diagnosis of hemophilia A in the Korean population, MspI/intron 22 and XbaI/intron 22 polymorphisms were analyzed in 101 unrelated Korean families with severe hemophilia A. The expected hetero.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.1
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma
Authors: Z.Z. Cai, L.B. Xu, J.L. Cai, J.S. Wang, B. Zhou and H. Hu
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pancreatic tissue samples (P = 0.007.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.31
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.31
Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization
Authors: K. Murugan, K. Kavitha and S. Al-Sohaibani
High-level methicillin-resistant Staphylococcus aureus (MRSA) isolates show rapid evolution of rifampicin resistance, forcing reliance upon expensive and often inferior antibiotics to manage these infections. Accordingly, this study was conducted to: 1) evaluate the level of multidrug resistance among hospital-associated MRSA isolates from Chennai, India;.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.1
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.1
Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns
Authors: Y.F. Chi, J.K. Chai, H.M. Luo, Q.X. Zhang and R. Feng
We explored the safety of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for healing burns in children. Subjects were randomly assigned to two groups: the experimental group received external rhGM-CSF gel, and the control group received rhGM-CSF gel matrix components, applied to the burn surface. Neither group was given any .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.3
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.3
A promoter trap vector for knocking out bovine myostatin gene with high targeting efficiency
Authors: L.H. Zhao, Y.H. Zhao, H. Liang, T. Yun, X.J. Han, M.L. Zhang, X. Zhou, D.X. Hou, R.F. Li and X.L. Li
With the development of gene targeting approaches, genomic mutation technologies in livestock animals such as gene trapping, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats and their associated systems have been improved. Although ZFNs have been used for gene targ.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.5
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.5
Chagas disease and triatomine biology (Heteroptera, Triatominae), with emphasis on aspects of spermatogenesis
Authors: R. Silistino-Souza
A century after the discovery of Chagas disease, it is still one of the most important parasitic diseases affecting humans. The subfamily Triatominae is important in medical health, because these insects are vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease. These insects are also of important cytological rel.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3ta039
- DOI:
- 10.4238/vol10-3ta039
Association of T869C gene polymorphism of transforming growth factor-�²1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women
Authors: D. Utennam, A. Tungtrongchitr, B. Phonrat, R. Tungtrongchitr and S. Preutthipan
Osteoporosis is the most common metabolic bone disease; it is an important health problem among postmenopausal women. We evaluated the association of three polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density (BMD) serum TGF-β1 levels in 278 postmenopausal female osteopenia/osteoporosi.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.2
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.2
Influence of �´�²-thalassemia or regulatory elements in individuals with increased fetal Hb levels in the S�£o Paulo northwest population
Authors: G.C.S. Carrocini and C.R. Bonini-Domingos
Fetal hemoglobin (Hb F), formed by two alpha globin chains (α) and two gamma chains (γ) (α2 γ2), has reduced expression in adults, ranging from 0 to 1% of total hemoglobin. Increased levels of Hb F are due to mutations in the β-globin family, which cause hereditary persistence of fetal hemoglobin (.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3ta035
- DOI:
- 10.4238/vol10-3ta035
The monotony of transferrin and esterase electrophoretic patterns in pirarucu, Arapaima gigas (Schinz, 1822) from Santa Cruz Lake, Tef�© River, Amazonas, Brazil
Authors: A.S. Teixeira
Starch gel electrophoresis was used for examining the transferrin gene locus (Tf) and two esterase gene loci (Est-1 and Est-D1) of a pirarucu (Arapaima gigas) population sample collected from Santa Cruz Lake, Tefé River, Amazonas, Brazil. The Tf locus was tentatively classified as being polymorphic, showing two double-b.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr425
- DOI:
- 10.4238/vol7-2gmr425
Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population
Authors: J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun and Y.J. Wang
The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.7
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.7