Human Genetics
TGF-?²1 polymorphisms and familial aggregation of liver cancer in Guangxi, China
Authors: P.Q. Wan, J.Z. Wu, L.Y. Huang, J.L. Wu, Y.H. Wei and Q.Y. Ning
The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.3
- DOI:
- 10.4238/2015.July.27.3
Immunomodulatory and clinical effects of the â??tiaomian III decoctionâ? in patients with blood blocking antibody deficiency and recurrent spontaneous abortion
Authors: H.Y. Gao, E.X. Tao, Y. Wang, Q.A. Yue, C.E. Ren and L.F. Yan
We studied the immunomodulatory and clinical effects of the empirical formula “tiaomian III decoction” on maternal blood blocking antibody deficiency and recurrent spontaneous abortion. Sixty-one patients with blocking antibody deficiency were divided in the experimental group (N = 31), who took tiaomian III decoction, and the control group (N.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.5
Association between polymorphism of ?²3-adrenoceptor gene and overactive bladder: a meta-analysis
Authors: H.C. Qu, W. Zhang, Y.L. Liu and P. Wang
Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.7
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.7
Influence of plasma exchange on transplantation related immune function in patients with liver failure
Authors: Y.M. Huo, C.C. Zhu, T.F. Lu and R. Hua
This study aimed to evaluate the influence of plasma exchange (PE) treatment of patients with liver failure on the patient’s immune function, including peripheral blood T lymphocytes and cytokines. Patients accepting PE for liver failure from October 2011 to February 2012 were included prospectively in the research group. Peripheral blood samples we.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.5
- DOI:
- 10.4238/2015.July.27.5
Myocardial protective effects of Munziq in myocardial ischemia-reperfusion injury rats with abnormal savda syndrome
Authors: M. Abudunaibi, A. Mulati, S. Aisikaer, M. Zulifeiya, J. Qiao, M. Gulibositan, A. Aili and U. Halmurat
This study evaluated the influence and mechanism of different Munziq doses on myocardial ischemia reperfusion injury (MIRI) rats with abnormal savda. Wistar rats (N = 96) were divided into the following 8 groups (12 rats each): ischemia-reperfusion (I/R) model group, high-dose, medium-dose, and low-dose Munziq groups, normal I/R group, sham model group, n.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.6
Sexual genetic and simple sequence repeat (SSR) analysis for molecular marker development on the all hermaphrodite papaya
Authors: C.T. Chiu, C.W. Wang, F.C. Chen, S.W. Chin, C.C. Liu, M.J. Lee, W.C. Chung, Y.W. Chien, H.J. Chang and C.Y. Lee
The papaya (Carica papaya L.) is one of the most important economic tropical fruits in the world, and the hermaphrodite is the preferred type in field cultures. We analyzed the sexual ratio of offspring from the cultivar ‘Taiwan Seed Station No. 7’ (T7) by a self-cross and its cross with Taichung Sunrise (TS). Female progeny from the T7 self-c.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.8
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.8
Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes
Authors: A. Teleginski, M. Welter, H.R. Frigeri, R.R. R?©a, E.M. Souza, D. Alberton, F.G.M. Rego, G. Picheth
Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to com.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019515
- DOI:
- 10.4238/gmr16019515
Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer
Authors: W.X. Hu, C.M. Ding, R.J. Li, H.Y. Fan, Z.J. Guo and W. Liu
The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) pa.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.9
MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis
Authors: X.Y. Shi and Q. Shen
Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were ret.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.8
- DOI:
- 10.4238/2015.July.27.8
Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors
Authors: H.Y. Zhang, X.B. Cheng, Y. Li, L.D. Jin, H.P. Yin
Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor eff.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019486
- DOI:
- 10.4238/gmr16019486