Human Genetics
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population J.
Authors: J.M. Liu, S.H. Cheng, C. Xia, T. Deng, Y.C. Zhu, X. Wei, Z.L. Huang, B.H. Liao, D.Y. Luo, Y.G. Zhang, T. Jin, K.J. Wang, J. Huang, H. Li
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated be.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019469
- DOI:
- 10.4238/gmr16019469
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis
Authors: J.H. Sung, B.E. Lee2, J.O. Kim2, Y.J. Jeon2, S.H. Kim1, S.W. Lim, J.Y. Moon, D.H. Cha, O.J. Kim, I.J. Kim and N.K. Kim
Coronary artery disease (CAD), a multifactorial disease, is a common cause of mortality in humans. Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk. However, the sample size of this previous study was too small and limited to comprehensively define .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases
Authors: Z.-Z. Liang, J. Li, S.-G. Huang
The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019329
- DOI:
- 10.4238/gmr16019329
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes
Authors: Y.L. Chen, D. Pei, Y.J. Hung, C.H. Lee, F.C. Hsiao, C.Z. Wu,J.D. Lin, C.H. Hsu, J.B. Chang and C.H. Hsieh
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjec.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.10
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.10
Analysis of SLC11A1 gene expression in healthy water buffalo (Bubalus bubalis) blood cells using qPCR
Authors: A. Cris� , G. De Matteis, M.C. Scat� and B. Moioli
SLC11A1 (solute carrier family 11 member 1 protein) gene influences the initial phase of bacterial cellular infections through macrophage activation. Recent literature on buffalo has attempted to associate the genotype of the polymorphic microsatellite located in the 3êÂ?Â?untranslated region (3êÂ?Â?UTR) of the gene, with either susceptibility to brucel.. Read More»
- Genet. Mol. Res. 12(4):
- 201
- DOI:
- 10.4238/201
Influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy
Authors: J.P. Liu, Y.H. Zhang, B. Yang, Q. Chen and L. Cao
The aim of this study was to determine the influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy. A total of 74 patients with esophageal carcinoma who underwent esophagectomy were divided into 2 groups according to whether or not their thoracic duct was ligated. Thirty-nine patients were in t.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.11
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.11
Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer
Authors: L.P. Chen, P.S. Cai and H.B. Liang
Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.15
- DOI:
- 10.4238/2015.July.27.15
Induction function of siRNA-mediated survivin gene silencing on nasopharyngeal carcinoma cell apoptosis
Authors: S.M. Fu, Z.H. Tu, L.Q. Deng, J.H. Cai, Z. Liang, Z.Q. Lin and Y.T. Wang
We examined the function of survivin gene expression in patients with nasopharyngeal carcinoma (NPC), as well as small interfering RNA (siRNA) on controlling CNE-2 NPC proliferation and apoptosis. Immunohistological methods, in situ hybridization, and reverse transcription-polymerase chain reaction technique were used to detect survivin protein and mRNA e.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.12
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.12
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells
Authors: C. Zhao, Z.G. Ma, S.L. Mou, Y.X. Yang, Y.H. Zhang, W.C. Yao
MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019281
- DOI:
- 10.4238/gmr16019281
Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population
Authors: W. Wan, X. Xu, D.B. Zhao, Y.F. Pang and Y.X. Wang
In this study, we analyzed single nucleotide polymorphisms (SNP) in urate transporter genes to examine the pathogenesis of gout. We conducted a 1:1-matched case-control study that included 110 patients with acute gout attacks as the patient group and 110 healthy age- and gender-matched subjects as the control group. Clinical parameters were recorded and b.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.13
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.13