Human Genetics
Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma
Authors: H.Z. Zhang, C.G. Shan, A.P. Huang and J.M. Wang
Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC m.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038206
- DOI:
- 10.4238/gmr.15038206
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Authors: S.C. Fan, J.G. Zhou and J.Z. Yin
We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was pe.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038268
- DOI:
- 10.4238/gmr.15038268
Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China
Authors: H.G. Zhang, W. Guo, H.F. Gu, S.B. Chen, J.Q. Wang, Z.X. Qiao, H.S. Ma and S.X. Geng
The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038274
- DOI:
- 10.4238/gmr.15038274
Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population
Authors: N. Jiang, Y.P. Peng, X.Y. Wang, C.W. Dou and W.M. He
In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038279
- DOI:
- 10.4238/gmr.15038279
New chromosomal evidence for the origin of Triatoma infestans populations from Brazil
Authors: N.P. Pereira, K.C.C. Alevi, J.A. Rosa and M.T.V. Azeredo-Oliveira
In this study, the karyometry of different Triatoma infestans populations from different states of Brazil was analyzed and compared with those of a population from Cochabamba. No significant differences were found between the population from Cochabamba and those from Brazil. These results are consistent with the origin of the T. infestans populations of B.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038303
- DOI:
- 10.4238/gmr.15038303
Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer
Authors: J. Li, Z.J. Song, Y.Y. Wang, Y. Yin, Y. Liu and X. Nan
MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038338
- DOI:
- 10.4238/gmr.15038338
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Authors: L.Q. Yang, Y. Zhang and H.F. Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038364
- DOI:
- 10.4238/gmr.15038364
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis
Authors: A.M. Barbosa, S.R. de Souza,, A.B. Frare, R.C. Costa e Silva, I.R. da Costa, K.S. Freitas e Silva, C.L. Ribeiro J�ºnior, B.M. Bordin and K.K.V.O. Moura
Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Soci.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038389
- DOI:
- 10.4238/gmr.15038389
Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells
Authors: C.F. Chang, J. Yang, W.M. Zhao, Y. Li, P.J. Guo, M.H. Li, Y. Zhou and C.S. Xu
We examined the gene expression profiles of the 5-hydroxytryptamine signaling pathway in the regenerating liver and 8 types of liver cells during rat liver regeneration, and explored expression differences in 5-hydroxytryptamine signaling pathway genes at the level of tissues and cells, as well as the role of the pathway on liver regeneration. Eight types.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.4
Association of the genes for tumor necrosis factor-�± and myelin basic protein with delayed encephalopathy after acute carbon monoxide poisoning
Authors: S.G. Li W.Q. Li J.K. Wang H.Y. Zhang W. Li P. Zhang X.H. Wang H.X. Zhang J.P. Gu R.J. Gu
There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5êÂ?Â?-side.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.19.1
- DOI:
- 10.4238/2012.December.19.1