Human Genetics
Association among oxidized LDL levels, MnSOD, apolipoprotein E polymorphisms, and cardiovascular risk factors in a south Brazilian region population
Authors: Maria G.V. Gottlieb, Carla H.A. Schwanke, Adriana F.R. Santos, Paulo F. Jobim, Denise P. M�¼ssel and Ivana B.M. da Cruz
Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic .. Read More»
- Genet. Mol. Res. 4(4):
Interleukin-10 promoter polymorphisms associated with susceptibility to lumbar disc degeneration in a Chinese cohort
Authors: W.P. Lin, J.H. Lin, X.W. Chen, C.Y. Wu, L.Q. Zhang, Z.D. Huang and J.M. Lai
We investigated a possible association between interleukin (IL)-10 single nucleotide polymorphisms (SNPs) and susceptibility to and severity of lumbar disc degeneration (LDD) in a Chinese cohort of 320 patients with LDD and 269 gender- and age-matched controls. The degree of disc degeneration was determined by magnetic resonan.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1283
- DOI:
- 10.4238/vol10-3gmr1283
REF: Genetics and Molecular Research 3 (4): 512 - 520, 2004
Authors: Sandro J. de Souza
-.. Read More»
- Genet. Mol. Res. 4(4):
Psychogenetics of Ullrich-Turner syndrome (an investigation of 28 subjects and respective controls through the Bender test and Piagetian scales) (PsicogenÃ?©tica da sÃ?Ândrome de Ullrich-Turner (investigaÃ?§Ã?£o de 28 sujeitos com respectivos controles atravÃ?©s do teste de Bender e das escalas de Piaget))
Authors: F�¡tima do Carmo Fonseca Ricardi
Piagetian scales (PS) and Bender visual motor gestalt test (BT), as well as laterality and Ishihara tests, were applied to 28 subjects with universal 45,X Ullrich-Turner syndrome (UTS), and their respective controls, in order to investigate their cognitive performance. Dermatoglyphics were also analyzed to obtain “clues&.. Read More»
- Genet. Mol. Res. 4(4):
Differential molecular response of the transcripts B2A2 and B3A2 to imatinib mesylate in chronic myeloid leukemia
Authors: Jos�© Alexandre Rodrigues de Lemos, Ciane Martins de Oliveira, Ana Carolina Costa Scerni, Alessandra Q. Bentes, Ana Cristina Beltr�£o, I�ª Regina G. Bentes, Tereza Cristina Azevedo and Luciana Maria Cunha Maradei-Pereira
Chronic myeloid leukemia (CML) originates from the hematopoietic stem cell and is characterized by the reciprocal translocation t(9;22)(q34;q11), which results in the BCR-ABL fusion gene on chromosome 22q-, also known as the Philadelphia chromosome. This chimeric gene codes for a cytoplasmic protein with constitutive tyrosinek.. Read More»
- Genet. Mol. Res. 4(4):
Effects of sodium lactate Ringerâ��s injection on transfection of human protein kinase C-�± antisense oligonucleotide in A549 lung cancer cells
Authors: Z.H. Wang, W.W. Sun, Y.L. Han and Z. Ma
In the present study, we evaluated the effects of four solutions [Dulbecco’s modified Eagle’s medium (DMEM), sodium lactate Ringer’s injection (SLRI), phosphate-buffered saline (PBS), and NaCl] on the transfection of the human protein kinase C-a antisense oligonucleotide (PKC-a ASO) aprinocarsen in human lung carcinoma A549 cells. Specif.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037650
- DOI:
- 10.4238/gmr.15037650
A genomic-scale search for regulatory binding sites in the integration host factor regulon of Escherichia coli K12
Authors: M. Trindade dos Santos and Paulo S�©rgio Rodrigues
We examined general aspects of the DNA-protein interaction between the integration host factor (IHF) global regulator and its regulatory binding sites in the Escherichia coli K12 genome. Two models were developed with distinct weight matrices for the regulatory binding sites recognized by IHF. Using these matrices we performed.. Read More»
- Genet. Mol. Res. 4(4):
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil
Authors: Rozany Mucha Dufloth, Sandra Costa, Fernando Schmitt and Luiz Carlos Zeferino
Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an.. Read More»
- Genet. Mol. Res. 4(4):
Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis
Authors: Y. Guan, L.H. Yan, X.Y. Liu, X.Y. Zhu, S.Z. Wang and L.M. Chen
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive met.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037969
- DOI:
- 10.4238/gmr.15037969
Association of IL-1�± gene polymorphism with susceptibility to type 1 diabetes in Chinese children
Authors: X. Zhou, J.G. Ca, H. Peng, J.L. Wang and G.M. Li
The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038025
- DOI:
- 10.4238/gmr.15038025