Human Genetics
Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer
Authors: Y.K. Zhang, B. Sun and G. Sui
Abnormal expression of microRNA-135a (miR-135a) is closely associated with oncogenesis. However, the relationship between serum miR-135a levels and the clinical parameters and prognosis of non-small cell lung cancer (NSCLC) remain unclear. The study aimed to investigate the clinical significance of serum miR-135a expression in patients with NSCLC. miR-135.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038252
- DOI:
- 10.4238/gmr.15038252
Expression and tyrosine phosphorylation of sp32 regulate the activation of the boar proacrosin/acrosin system
Authors: H.T. Dong, W.S. Shi, Y. Tian, L.P. Cao and Y. Jin
The current study investigated the relationship between the level of expression and tyrosine phosphorylation of the sperm protein 32 (sp32) and the activation of the boar proacrosin/acrosin system. The acrosomal membrane proteins of boar sperm for use in different treatment experiments (i.e., fresh sperm, freezing and thawing, capacitation, and acrosome r.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.23
- DOI:
- 10.4238/2015.March.27.23
Management of clinically negative nodes (N0) in supraglottic laryngeal carcinoma: A systematic review
Authors: Y.H. Liu and Z.W. Du
The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. Th.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048179
- DOI:
- 10.4238/gmr15048179
Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease
Authors: L. Wu, M.H. Zhao, G.Y. Geng, L. Mao and H.J. Liu
Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047823
- DOI:
- 10.4238/gmr15047823
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer
Authors: Alessandra D. Clarizia, Luciana Bastos-Rodrigues, HeloÃ?Âsa B. Pena, Charles Anacleto, Benedito Rossi, Fernando A. Soares, Ademar Lopes, JosÃ?© ClÃ?¡udio C. Rocha, OtÃ?¡via Caballero, Anamaria Camargo, Andrew J.G. Simpson and SÃ?©rgio D.J. Pena
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Conside.. Read More»
- Genet. Mol. Res. 5(2):
LECT2 association with macrophage-mediated killing of Helicobacter pylori by activating NF-�ºB and nitric oxide production
Authors: H.X. Shen, L. Li, Q. Chen, Y.Q. He, C.H. Yu, C.Q. Chu, X.J. Lu and J. Chen
Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activa.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048889
- DOI:
- 10.4238/gmr15048889
Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy
Authors: Q. Wang, F. Duan, P. Liu, P.F. Wang and M.X. Wang
This study aimed to investigate the role of anti-SRP19 antibody in muscle tissues of patients with autoimmune necrotizing myopathy. Immunohistochemistry staining was used to determine the expression of anti-SRP19 antibodies in muscle tissues of autoimmune necrotizing myopathy patients. Results demonstrated that anti-SRP19 antibody was expressed in 71.4% (.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038307
- DOI:
- 10.4238/gmr.15038307
Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
Authors: Y.Y. Shi and H. Jiang
This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. A comprehensive literature search in the electronic databases, including PubMed, EMBASE, and Wanfang (up to December 1, 2015), was conducted. Publications a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038325
- DOI:
- 10.4238/gmr.15038325
Detection of targets and their mechanisms for early diagnosis of traumatic deep vein thrombosis
Authors: J.W. Mo, D-F. Zhang, G.L. Ji, X.-Z. Liu and B. Fan
The purpose of this investigation was to identify targets for the early diagnosis and predictors of deep venous thrombosis (DVT) and the role of these targets in the formation of venous thrombosis. A model of DVT was constructed in rats. Thromboses and venous walls were sampled for reverse transcription polymerase chain reaction study, and blood was sampl.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.27.26
- DOI:
- http://dx.doi.org/10.4238/2015.March.27.26
Development and characterization of novel EST-SSR markers and their application for genetic diversity analysis of Jerusalem artichoke (Helianthus tuberosus L.)
Authors: T. Mornkham, P.P. Wangsomnuk, X.C. Mo, F.O. Francisco, L.Z. Gao and H. Kurzweil
Jerusalem artichoke (Helianthus tuberosus L.) is a perennial tuberous plant and a traditional inulin-rich crop in Thailand. It has become the most important source of inulin and has great potential for use in chemical and food industries. In this study, expressed sequence tag (EST)-based simple sequence repeat (SSR) markers we.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048857
- DOI:
- 10.4238/gmr15048857