Human Genetics
Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells
Authors: Y.P. Zhang, Y.Q. Li, Y.T. Lv and J.M. Wang
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentratio.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.9
- DOI:
- 10.4238/2015.February.6.9
Chest wall recurrence location and the lower-bound target of preventive radiotherapy after transverse incision in modified radical mastectomy
Authors: F.P. Wu, J. Wang, H. Wang, Y.J. Liu, N. Li and Z.K. Liu
We investigated the relationship between the lower-bound target of preventive radiation to the chest wall after modified radical mastectomy with a transverse incision and preoperative breast carcinoma characteristics to provide a basis for reducing radiation injury to neighboring tissues and individualizing preventive chest wall radiation targets. We anal.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.10
- DOI:
- 10.4238/2015.February.6.10
Effect of leptin gene polymorphisms on growth, slaughter and meat quality traits of grazing Brangus steers
Authors: P.M. Corva G.V. Fern�¡ndez Macedo L.A. Soria J. Papaleo Mazzucco M. Motter E.L. Villarreal A. Schor C.A. Mezzadra L.M. Melucci M.C. Miquel
Leptin is a hormone that affects the regulation of feed intake, energy balance and body composition in mammals. Several polymorphisms in the bovine leptin gene have been associated with phenotypic variance of these traits. We evaluated two known single nucleotide polymorphisms (SNPs) in the leptin gene of 253 grazing Brangus s.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr556
- DOI:
- 10.4238/vol8-1gmr556
Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis
Authors: B.W. Yu, L.Q. Zhang, X.L. Teng, Y. Zhang, L.B. Zou and H.Y. Ying
Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 Tï¼Â?C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.11
- DOI:
- 10.4238/2015.February.6.11
Gene expression profile in breast cancer comprising predictive markers for metastatic risk
Authors: S. Sirirattanakul, P. Wannakrairot, T. Tencomnao and R. Santiyanont
Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive marker.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.3
Highly conserved regions in the 5� region of human olfactory receptor genes
Authors: H.F. Tobar P.A. Moreno P.E. V�©lez
Regulation of human olfactory receptor (hOR) genes is a complex process of control and signalization with various structures and functions that are not clearly understood. To date, nearly 390 functional hOR genes and 462 pseudogenes have been discovered in the human genome. Enhancer models and trans-acting elements for the reg.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr550
- DOI:
- 10.4238/vol8-1gmr550
Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
Authors: P.K. Mishra A. Bhargava G.V. Raghuram S. Gupta S. Tiwari R. Upadhyaya S.K. Jain K.K. Maudar
Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as i.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr544
- DOI:
- 10.4238/vol8-1gmr544
Association between interleukin 17A gene polymorphisms and risk of coronary artery disease
Authors: X.S. Zheng1, S. Wang2 and M. Ni3
Coronary artery disease (CAD) represents a leading cause of morbidity and mortality worldwide, and genetic factors contribute to the development of this disease. We conducted a case-control study to assess the association between interleukin 17A (IL17A) rs2275913 and rs3748067 polymorphisms and development of CAD. A total of 372 CAD patients and 372 healt.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017074
- DOI:
- 10.4238/gmr.15017074
PI3K, AKT, and P-AKT levels in thin endometrium
Authors: A.W. Le1, L.L. Shan1, X.Y. Dai1, T.H. Xiao1, X.R. Li1, Z.H. Wang1, J. Zhang2 and X.Y. Chen3
The aim of this study was to explore the expression of PI3K, AKT, and P-AKT, and to investigate the role of PI3K/AKT signaling pathway in thin endometrium. We included 40 women treated in affiliated Shenzhen Nanshan People’s Hospital of Guangdong Medical University for endometrial conditions between August 2013 and January 2015, 20 with a normal end.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017184
- DOI:
- 10.4238/gmr.15017184
Y-STR genetic screening by high-resolution melting analysis
Authors: J.Q. Deng1*, B.Q. Liu2*, Y. Wang3, W. Liu4, J.F. Cai5, R. Long1 and W.H. Li1
Currently, the widely used automated capillary electrophoresis-based short tandem repeat (STR) genotyping method for genetic screening in forensic practice is laborious, time-consuming, expensive, and technically challenging in some cases. Thus, new molecular-based strategies for conclusively identifying forensically relevant biological evidence are requi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.1501726605/02/2016
- DOI:
- 10.4238/gmr.1501726605/02/2016